Featured Publications
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 2016, 354: 765-768. PMID: 27846608, PMCID: PMC5640175, DOI: 10.1126/science.aaf7532.Peer-Reviewed Original ResearchConceptsCell deathDNA sensor AIM2New therapeutic targetsCaspase-1-dependent deathIntestinal epithelial cellsBone marrow cellsGastrointestinal syndromeTissue injuryInflammasome activationGastrointestinal tractRadiation-induced cell deathRadiation-induced DNA damageTherapeutic targetAcute exposureBone marrowChemotherapeutic agentsMarrow cellsRadiation exposureAIM2Massive cell deathEpithelial cellsHematopoietic failureDeathMolecular mechanismsDNA damage
2013
Inflammasome biology in fibrogenesis
Ouyang X, Ghani A, Mehal WZ. Inflammasome biology in fibrogenesis. Biochimica Et Biophysica Acta 2013, 1832: 979-988. PMID: 23562491, DOI: 10.1016/j.bbadis.2013.03.020.Peer-Reviewed Original ResearchConceptsInflammatory pathwaysInflammatory responseTissue injuryToll-like receptor agonistsAssociation of TGFPro-fibrotic pathwaysDownstream inflammatory cytokinesCytokines interleukin-1βAcute inflammatory responseTumor necrosis factorLiver stellate cellsNew therapeutic targetsNumber of organsTissue macrophage populationsIL-18Inflammatory cytokinesInterleukin-1βReceptor agonistFibrogenic responseImmune cellsNecrosis factorSterile insultsStellate cellsTherapeutic targetMacrophage populations