2015
Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing
Jiang Y, Wu R, Chen C, You ZF, Luo X, Wang XP. Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing. Journal Of Neurogenetics 2015, 29: 188-194. PMID: 26814133, DOI: 10.3109/01677063.2015.1122787.Peer-Reviewed Original ResearchMeSH KeywordsCalcium-Binding ProteinsChloride ChannelsComputational BiologyDNA Mutational AnalysisExomeFamily HealthFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGTPase-Activating ProteinsGTP-Binding ProteinsHumansMaleMembrane GlycoproteinsMigraine without AuraMucinsMutationPolymorphism, Single NucleotideReceptors, G-Protein-CoupledUbiquitin-Conjugating EnzymesXedar ReceptorConceptsNon-synonymous mutationsRare non-synonymous mutationsExome sequencingNovel non-synonymous mutationsBioinformatics analysisX chromosomeMultiple genesCellular responsesWhole-exome sequencingSusceptibility gene mutationsCell membrane potentialARHGAP28MutationsSequencingProteinGBP2Membrane potentialEMR1Gene mutationsChemical factorsCLCNKBChromosomesGenesVasogenic theoryGenetic predisposition
2006
Mutation screen of the GAD2 gene and association study of alcoholism in three populations
Lappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 144B: 183-192. PMID: 17034009, DOI: 10.1002/ajmg.b.30377.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanCase-Control StudiesDNA Mutational AnalysisExonsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic TestingGlutamate DecarboxylaseHispanic or LatinoHumansIsoenzymesLinkage DisequilibriumMaleMutationPolymorphism, Single NucleotideStudentsUnited StatesWhite PeopleConceptsSingle nucleotide polymorphismsGAD2 geneNon-synonymous polymorphismsAssociation studiesSequence variantsGamma-amino butyric acidGlutamate decarboxylase 2GenesMutation screenNucleotide polymorphismsAdditional populationsMajor enzymeG single nucleotide polymorphismPolymorphismG variantButyric acidPopulationVariantsEnzymeAdditional samplesRoleRussian malesVariationScreenDHPLC
2005
ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies
Luo X, Kranzler HR, Zuo L, Lappalainen J, Yang BZ, Gelernter J. ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies. Neuropsychopharmacology 2005, 31: 1085-1095. PMID: 16237392, DOI: 10.1038/sj.npp.1300925.Peer-Reviewed Original ResearchAdultAlcohol DehydrogenaseAlcohol-Induced Disorders, Nervous SystemAlcoholismAmericasDNA Mutational AnalysisEuropeFemaleGenes, RecessiveGenetic MarkersGenetic Predisposition to DiseaseGenetic TestingGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticSubstance-Related DisordersWhite People