2023
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderCalcium Channels, L-TypeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansParkinson DiseasePolymorphism, Single NucleotideRNA, MessengerSchizophreniaConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDisease
2022
Further evidence and meta-analysis support association of a single nucleotide polymorphism rs4765905 in CACNA1C with schizophrenia
Wang Z, Fu Y, Jiang F, Chen L, Chen W, Guo X, Luo X. Further evidence and meta-analysis support association of a single nucleotide polymorphism rs4765905 in CACNA1C with schizophrenia. Schizophrenia Research 2022, 243: 454-455. PMID: 35221147, DOI: 10.1016/j.schres.2022.01.052.Peer-Reviewed Original ResearchMeSH KeywordsCalcium Channels, L-TypeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideSchizophrenia
2021
An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia
Wang Z, Chen W, Cao Y, Dou Y, Fu Y, Zhang Y, Luo X, Kang L, Liu N, Shi YS, Li CR, Xu Y, Guo X, Luo X. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 385-397. PMID: 33938268, DOI: 10.1177/00048674211009595.Peer-Reviewed Original ResearchMeSH KeywordsCalcium Channels, L-TypeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntronsPolymorphism, Single NucleotideRNA, MessengerSchizophreniaConceptsMessenger RNA expressionGray matter volumeMatter volumeSingle nucleotide polymorphismsRisk allelesRNA expressionPathogenesis of schizophreniaSingle nucleotide polymorphism (SNP) rs1006737Isthmus cingulate cortexMinor allele ARisk single nucleotide polymorphismsBrain cohortCingulate cortexBrain regionsCortical regionsSubcortical structuresSchizophreniaRs1006737Allele ARegulatory effectsRisk genesSignificant risk genesCohortCortexAfrican American sample
2020
KTN1 variants and risk for attention deficit hyperactivity disorder
Luo X, Guo X, Tan Y, Zhang Y, Garcia‐Milian R, Wang Z, Shi J, Yu T, Ji J, Wang X, Xu J, Zhang H, Zuo L, Lu L, Wang K, Li C. KTN1 variants and risk for attention deficit hyperactivity disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2020, 183: 234-244. PMID: 32190980, PMCID: PMC7210069, DOI: 10.1002/ajmg.b.32782.Peer-Reviewed Original ResearchSignificant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence
Luo X, Guo X, Luo X, Tan Y, Zhang P, Yang K, Xie T, Shi J, Zhang Y, Xu J, Zuo L, Li C. Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. Addiction Biology 2020, 26: e12888. PMID: 32115811, PMCID: PMC7641293, DOI: 10.1111/adb.12888.Peer-Reviewed Original Research
2017
Response from Original Authors - RE: Six novel rare nonsynonymous mutations for migraine without aura identified by exome sequencing
Wang XP, Xu ZX, Sun XJ, Luo X. Response from Original Authors - RE: Six novel rare nonsynonymous mutations for migraine without aura identified by exome sequencing. Journal Of Neurogenetics 2017, 31: 322-324. PMID: 29037100, DOI: 10.1080/01677063.2017.1382491.Peer-Reviewed Original ResearchAnalysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol
Chen Y, Xu C, Harirforoosh S, Luo X, Wang KS. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal Of Psychiatric Research 2017, 96: 65-72. PMID: 28987514, PMCID: PMC6195678, DOI: 10.1016/j.jpsychires.2017.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCerebellumCholesterolComputer SimulationFamilyGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiddle AgedNeoplasmsPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2ConceptsRisk of ADRisk of cancerAlzheimer's diseaseAAO of ADSingle nucleotide polymorphismsTotal cholesterol levelsMultiple logistic regressionLDL cholesterolTotal cholesterolCholesterol levelsAD patientsCancer riskMultiple linear regression analysisLinear regression analysisNeuropsychiatric disordersLogistic regressionDiseaseCancerWilcoxon testExpression levelsRiskRegression analysisGene expression levelsHuman brainGenetic variantsGenome-wide significant, replicated and functional risk variants for Alzheimer’s disease
Guo X, Qiu W, Garcia-Milian R, Lin X, Zhang Y, Cao Y, Tan Y, Wang Z, Shi J, Wang J, Liu D, Song L, Xu Y, Wang X, Liu N, Sun T, Zheng J, Luo J, Zhang H, Xu J, Kang L, Ma C, Wang K, Luo X. Genome-wide significant, replicated and functional risk variants for Alzheimer’s disease. Journal Of Neural Transmission 2017, 124: 1455-1471. PMID: 28770390, PMCID: PMC5654670, DOI: 10.1007/s00702-017-1773-0.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseApolipoproteins EGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideProteinsRisk FactorsConceptsGenome-wide association studiesNon-coding RNAsRisk variantsRisk genesProtein-coding genesProtein-coding RNAsLong non-coding RNAsFunctional risk variantsPotential biological functionsAD-related pathwaysExpression of piRNAsAlterations of proteinsGenomic regionsExpression correlationBiological functionsProtein structureAssociation studiesMetabolism pathwaysLipoprotein metabolism pathwaysRisk SNPsGenesSNPsPiRNAsRNARegulatory effectsFamily-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease
Wang KS, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Journal Of Neuroimmunology 2017, 310: 60-65. PMID: 28778446, PMCID: PMC6167010, DOI: 10.1016/j.jneuroim.2017.06.010.Peer-Reviewed Original ResearchConceptsRisk of ADAlzheimer's diseaseSingle nucleotide polymorphismsAAO of ADHuman brain regionsNervous system developmentApoE expressionOnset (AAO) of ADBrain regionsDiseaseSignificant expressionRiskMarker analysisGenetic variantsAssociationFamily-based association analysisHaplotype analysisPresent studyEquation statisticsAgeFirst studyOnsetFamily-based associationFamily-based sampleExpression
2016
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Zuo L, Tan Y, Li C, Wang Z, Wang K, Zhang X, Lin X, Chen X, Zhong C, Wang X, Wang J, Lu L, Luo X. Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 1057-1071. PMID: 27473937, PMCID: PMC5587505, DOI: 10.1002/ajmg.b.32476.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAnimalsBlack or African AmericanCase-Control StudiesDatabases, Nucleic AcidFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiceNicotinePolymorphism, Single NucleotideReceptors, NicotinicTobacco Use DisorderWhite PeopleConceptsCHRN genesGenomic regionsNicotine dependenceAD risk genesAlcohol dependenceRare variantsNicotinic cholinergic receptor genesRewarding effectsDistinct subunitsMouse brainGenesMicroarray platformRisk genesNicotine's rewarding effectsCholinergic receptor genesReceptor geneSpecific brain areasDifferent neuropsychiatric disordersIndependent cohortDiscrete regionsWhole mouse brainBrain areasNeuropsychiatric disordersMRNA expressionBrainAssociations of THBS2 and THBS4 polymorphisms to gastric cancer in a Southeast Chinese population
Lin X, Hu D, Chen G, Shi Y, Zhang H, Wang X, Guo X, Lu L, Black D, Zheng XW, Luo X. Associations of THBS2 and THBS4 polymorphisms to gastric cancer in a Southeast Chinese population. Cancer Genetics 2016, 209: 215-222. PMID: 27160021, DOI: 10.1016/j.cancergen.2016.04.003.Peer-Reviewed Original ResearchConceptsGastric cancerSoutheast Chinese populationThrombospondin-2Thrombospondin-4MRNA expressionChinese populationHuman GC tumorsMouse stomach tissuesDiffuse-type gastric cancerCase-control setsClinicopathological featuresTumor sizePoor prognosisReal-time PCRGC tumorsUnfavorable genotypesPrognosis predictionGC casesMouse stomachModest associationStomach tissueCancer developmentGC riskMRNA overexpressionHuman stomach
2015
BDNF polymorphisms are associated with schizophrenia onset and positive symptoms
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with schizophrenia onset and positive symptoms. Schizophrenia Research 2015, 170: 41-47. PMID: 26603468, DOI: 10.1016/j.schres.2015.11.009.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPositive symptomsBDNF gene variantsCase-control studyBDNF gene polymorphismClinical symptom severityPathophysiology of schizophreniaNegative Syndrome ScaleHan Chinese populationBDNF polymorphismNeurotrophic factorBDNF geneSchizophrenia onsetGene polymorphismsSyndrome ScalePotential associationChinese populationSymptom severityHan Chinese individualsSymptomsPatientsSchizophreniaGene variantsPsychopathological symptomsChinese individualsSix novel rare non-synonymous mutations for migraine without aura identified by exome sequencing
Jiang Y, Wu R, Chen C, You ZF, Luo X, Wang XP. Six novel rare non-synonymous mutations for migraine without aura identified by exome sequencing. Journal Of Neurogenetics 2015, 29: 188-194. PMID: 26814133, DOI: 10.3109/01677063.2015.1122787.Peer-Reviewed Original ResearchMeSH KeywordsCalcium-Binding ProteinsChloride ChannelsComputational BiologyDNA Mutational AnalysisExomeFamily HealthFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGTPase-Activating ProteinsGTP-Binding ProteinsHumansMaleMembrane GlycoproteinsMigraine without AuraMucinsMutationPolymorphism, Single NucleotideReceptors, G-Protein-CoupledUbiquitin-Conjugating EnzymesXedar ReceptorConceptsNon-synonymous mutationsRare non-synonymous mutationsExome sequencingNovel non-synonymous mutationsBioinformatics analysisX chromosomeMultiple genesCellular responsesWhole-exome sequencingSusceptibility gene mutationsCell membrane potentialARHGAP28MutationsSequencingProteinGBP2Membrane potentialEMR1Gene mutationsChemical factorsCLCNKBChromosomesGenesVasogenic theoryGenetic predispositionSignificant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians
Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBeta KaryopherinsBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ARisk FactorsWhite PeopleConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeuropsychiatric disordersRare variantsHyperactivity disorderDifferent neuropsychiatric disordersRNA expression changesIndependent cohortSignificant associationSignificant regulatory effectDisordersCaucasiansEuropean descentRegulatory effectsHuman brainDiseaseAssociationCis-eQTL analysisIPO11African descentExpression changesSubjectsCohortFalse discovery rateVariants
2014
Smoking and BDNF Val66Met polymorphism in male schizophrenia: A case-control study
Zhang XY, Chen DC, Tan YL, Luo X, Zuo L, Lv MH, Shah NN, Zunta-Soares GB, Soares JC. Smoking and BDNF Val66Met polymorphism in male schizophrenia: A case-control study. Journal Of Psychiatric Research 2014, 60: 49-55. PMID: 25455509, DOI: 10.1016/j.jpsychires.2014.09.023.Peer-Reviewed Original ResearchConceptsVal/Val genotypeBDNF Val66Met polymorphismHealthy controlsNicotine dependenceVal66Met polymorphismVal genotypeSchizophrenia patientsChronic male schizophrenia patientsMet alleleBDNF Val66Met gene polymorphismBDNF Val66Met genotypePANSS negative symptomsHigher FTND scoresCase-control studyMale schizophrenia patientsNegative Syndrome ScaleChinese Han populationCase-control designVal66Met genotypeMore hospitalizationsPatient groupSmoking indexMale schizophreniaFagerstrom TestHigh HSI scores
2013
Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence
Zuo L, Wang K, Zhang X, Pan X, Wang G, Krystal JH, Zhang H, Luo X. Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. Psychiatric Genetics 2013, 23: 233-238. PMID: 23907288, PMCID: PMC3941913, DOI: 10.1097/ypg.0b013e328364b8c7.Peer-Reviewed Original ResearchNRG3 gene is associated with the risk and age at onset of Alzheimer disease
Wang KS, Xu N, Wang L, Aragon L, Ciubuc R, Arana TB, Mao C, Petty L, Briones D, Su BB, Luo X, Camarillo C, Escamilla MA, Xu C. NRG3 gene is associated with the risk and age at onset of Alzheimer disease. Journal Of Neural Transmission 2013, 121: 183-192. PMID: 24061483, DOI: 10.1007/s00702-013-1091-0.Peer-Reviewed Original ResearchCommon PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence
Zuo L, Wang K, Wang G, Pan X, Zhang X, Zhang H, Luo X. Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence. American Journal On Addictions 2013, 23: 411-414. PMID: 24961364, PMCID: PMC4111256, DOI: 10.1111/j.1521-0391.2013.12115.x.Peer-Reviewed Original ResearchGenome-wide association studies of maximum number of drinks
Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, Wang W, Zuo L, Wang KS. Genome-wide association studies of maximum number of drinks. Journal Of Psychiatric Research 2013, 47: 1717-1724. PMID: 23953852, PMCID: PMC4286179, DOI: 10.1016/j.jpsychires.2013.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol-Related DisordersAustraliaCase-Control StudiesCocaine-Related DisordersCommunity Health PlanningFamily HealthFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideTobacco Use DisorderWhite PeopleConceptsGenome-wide association studiesSingle nucleotide polymorphismsGenes/regionsAustralian twin-family studyAssociation studiesFirst genome-wide association studyGene discoveryAlcohol consumption phenotypeFamily sampleAddiction geneticsConsumption phenotypesAlcoholism (COGA) sampleDDC geneCaucasian samplesContinuous phenotypesMaxDrinksSage samplesPhenotypeIntermediate phenotypesGenesSignificant associationAlcohol dependenceAssociation study on tardive dyskinesia and polymorphisms in COMT and MAOA in Chinese population
Li H, Tan Y, Wang Z, Yang F, Zuo L, Luo X. Association study on tardive dyskinesia and polymorphisms in COMT and MAOA in Chinese population. Psychiatric Genetics 2013, 23: 176. PMID: 23344637, DOI: 10.1097/ypg.0b013e32835e8df6.Peer-Reviewed Original Research