2021
Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2
2016
Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury
Cao Y, Gao Y, Xu S, Bao J, Lin Y, Luo X, Wang Y, Luo Q, Jiang J, Neale JH, Zhong C. Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury. BMC Neuroscience 2016, 17: 15. PMID: 27091009, PMCID: PMC4836105, DOI: 10.1186/s12868-016-0251-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-2-Associated X ProteinBrain InjuriesCaspase 3Cerebral CortexGlutamate Carboxypeptidase IIMaleMiceMice, KnockoutMitochondriaOxidative StressProto-Oncogene Proteins c-bcl-2ConceptsTraumatic brain injuryWild-type miceBrain injuryKnockout miceNeuroprotective efficacyType miceImpact injuryOxidative stressCortical impact injuryInjury-induced increaseBcl-2/Bax ratioGene knockout miceGlutathione peroxidase activityCerebral cortexCortical apoptosisKO miceCytosolic cytochrome c levelsConclusionsThese dataN-acetylaspartylglutamateSynaptic releaseTUNEL-positive nucleiAnimal modelsExtracellular levelsCytochrome c levelsGlutathione levels