2020
Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder
Wang W, Liu Y, Luo S, Guo X, Luo X, Zhang Y. Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder. Brain And Behavior 2020, 10: e01885. PMID: 33047489, PMCID: PMC7749616, DOI: 10.1002/brb3.1885.Peer-Reviewed Original ResearchMeSH KeywordsBrain-Derived Neurotrophic FactorCognitive DysfunctionGenotypeHumansPanic DisorderPolymorphism, GeneticPolymorphism, Single NucleotideConceptsBDNF Met/Met genotypeMet/Met genotypeLower BDNF plasma levelsPanic disorderCognitive impairmentMet genotypeMontreal Cognitive AssessmentStroop interferenceVerbal learningNeurocognitive measuresCognitive performanceBDNF plasma levelsMoCA dataCognitive AssessmentAnxiety ScaleBDNF Val66Met polymorphismVal/ValPanic symptomsLower scoresPD patientsHamilton Anxiety ScaleProcessing domainPlasma levelsHealthy controlsModerate positive correlation
2016
BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls.
Zhang XY, Chen da C, Tan YL, Tan S, Luo X, Zuo L, Soares JC. BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls. The Journal Of Clinical Psychiatry 2016, 77: e1011-8. PMID: 27561148, DOI: 10.4088/jcp.15m10269.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain-Derived Neurotrophic FactorCase-Control StudiesChinaCognitionCognitive DysfunctionFemaleHumansMaleMiddle AgedPolymorphism, GeneticSchizophreniaConceptsBrain-derived neurotrophic factorHealthy controlsCognitive functionBDNF gene variantsCase-control studyBDNF genetic variantsBDNF gene polymorphismPathogenesis of schizophreniaCognitive performanceRBANS total scoreHan Chinese populationBDNF polymorphismVal66Met polymorphismNeurotrophic factorBDNF geneGene polymorphismsCognitive impairmentPatientsPotential associationChinese populationNeuropsychological StatusHan Chinese individualsRepeatable BatterySchizophreniaTotal scoreAssociation of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjectsAssociations of THBS2 and THBS4 polymorphisms to gastric cancer in a Southeast Chinese population
Lin X, Hu D, Chen G, Shi Y, Zhang H, Wang X, Guo X, Lu L, Black D, Zheng XW, Luo X. Associations of THBS2 and THBS4 polymorphisms to gastric cancer in a Southeast Chinese population. Cancer Genetics 2016, 209: 215-222. PMID: 27160021, DOI: 10.1016/j.cancergen.2016.04.003.Peer-Reviewed Original ResearchConceptsGastric cancerSoutheast Chinese populationThrombospondin-2Thrombospondin-4MRNA expressionChinese populationHuman GC tumorsMouse stomach tissuesDiffuse-type gastric cancerCase-control setsClinicopathological featuresTumor sizePoor prognosisReal-time PCRGC tumorsUnfavorable genotypesPrognosis predictionGC casesMouse stomachModest associationStomach tissueCancer developmentGC riskMRNA overexpressionHuman stomach
2013
Association study on tardive dyskinesia and polymorphisms in COMT and MAOA in Chinese population
Li H, Tan Y, Wang Z, Yang F, Zuo L, Luo X. Association study on tardive dyskinesia and polymorphisms in COMT and MAOA in Chinese population. Psychiatric Genetics 2013, 23: 176. PMID: 23344637, DOI: 10.1097/ypg.0b013e32835e8df6.Peer-Reviewed Original ResearchAssociation of the dopamine β‐hydroxylase 19 bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia
Zhou N, Yu Q, Li X, Yu Y, Kou C, Li W, Xu H, Luo X, Zuo L, Kosten TR, Zhang XY. Association of the dopamine β‐hydroxylase 19 bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia. Human Psychopharmacology Clinical And Experimental 2013, 28: 230-237. PMID: 23559427, DOI: 10.1002/hup.2311.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaPositive symptomsDel polymorphismSeverity of TDAIMS total scoreDel/del genotypeBp insertion/deletion polymorphismIns/ins genotypeNegative Syndrome ScaleSignificant differencesInsertion/deletion polymorphismConversion of dopamineIns/delSymptom subscoresChinese patientsTD patientsDopaminergic neurotransmissionHealthy controlsMovement ScaleDBH activityPatientsSyndrome ScaleDel genotypeTD severity
2003
Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1)
Hernandez‐Avila C, Wand G, Luo X, Gelernter J, Kranzler HR. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1). American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 118B: 60-65. PMID: 12627468, DOI: 10.1002/ajmg.b.10054.Peer-Reviewed Original ResearchConceptsCortisol responseAsn40 alleleAsn40Asp polymorphismAsp40 alleleCortisol concentrationsCortisol time curveMu-opioid receptor proteinOpioid antagonist naloxoneMin post infusionPeak cortisol responsePlasma ACTH concentrationsEnhanced cortisol responseHigher cortisol concentrationsWarrants further investigationAsp40 variantIntravenous naloxoneOpioid blockadeNaloxone infusionAntagonist naloxonePlasma ACTHACTH concentrationsAgonist effectsPost infusionHealthy subjectsClinical relevance