2023
Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanism
2021
EXT1 methylation promotes proliferation and migration and predicts the clinical outcome of non‐small cell lung carcinoma via WNT signalling pathway
Kong W, Chen Y, Zhao Z, Zhang L, Lin X, Luo X, Wang S, Song Z, Lin X, Lai G, Yu Z. EXT1 methylation promotes proliferation and migration and predicts the clinical outcome of non‐small cell lung carcinoma via WNT signalling pathway. Journal Of Cellular And Molecular Medicine 2021, 25: 2609-2620. PMID: 33565239, PMCID: PMC7933929, DOI: 10.1111/jcmm.16277.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Non-Small-Cell LungCell Line, TumorCell MovementCell ProliferationCpG IslandsDNA MethylationGene Expression Regulation, NeoplasticHumansLung NeoplasmsN-AcetylglucosaminyltransferasesNeoplasm GradingNeoplasm StagingPrognosisSurvival AnalysisWnt Signaling PathwayConceptsGene expressionGene body methylationDNA methylation levelsPotential downstream targetsDNA methylation sitesDNA methylationMethylation sitesDownstream targetsMethylation levelsWnt pathwayCpG sitesNSCLC cell linesMethylationWntExpression levelsCell linesPathway patternsPotential targetXAV-939EXT1ProliferationMigration ratePathwayExpressionUnderlying mechanism
2019
Transcriptome-wide piRNA profiling in human brains for aging genetic factors.
Mao Q, Fan L, Wang X, Lin X, Cao Y, Zheng C, Zhang Y, Zhang H, Garcia-Milian R, Kang L, Shi J, Yu T, Wang K, Zuo L, Li CR, Guo X, Luo X. Transcriptome-wide piRNA profiling in human brains for aging genetic factors. 2019, 4 PMID: 32149191, PMCID: PMC7059831.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsAge-associated genesCritical genetic determinantsGenomic integrityExpression regulationCancer stem cellsMicroarray technologyGenetic determinantsStem cellsExpression levelsRenewal capacityMolecular featuresBiological systemsPotential roleGenetic factorsYears of survivalUnderlying mechanismHuman prefrontal cortexGermlineGenesRNADisease statusMultiple testingPrefrontal cortex