2021
Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia
Zhou Y, Huang J, Zhang P, Tong J, Fan F, Gou M, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yang F, Tian B, Tian L, Savransky A, Hare S, Ryan MC, Goldwaser E, Chiappelli J, Chen S, Kochunov P, Kvarta M, Tan Y, Hong LE. Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia. Schizophrenia Bulletin 2021, 47: 1048-1057. PMID: 33501486, PMCID: PMC8266595, DOI: 10.1093/schbul/sbaa196.Peer-Reviewed Original ResearchConceptsHigher allostatic loadCognitive deficitsCortical thicknessCortical thinningAllostatic loadCholesterol levelsSchizophrenia patientsLow high-density lipoprotein cholesterolHypersensitive C-reactive proteinHigh-density lipoprotein cholesterolLower total cholesterol levelsDiastolic blood pressureTotal cholesterol levelsC-reactive proteinWaist-hip ratioLeft superior frontal gyrusHigh cholesterol levelsMean cortical thicknessHigher heart rateSuperior frontal gyrusEarly intervention strategiesGray matter integrityNormoweight patientsLipoprotein cholesterolBlood pressure
2020
Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI
Mu Y, Li Y, Zhang Q, Ding Z, Wang M, Luo X, Guo X, Xu M. Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI. General Psychiatry 2020, 33: e100147. PMID: 32695958, PMCID: PMC7351268, DOI: 10.1136/gpsych-2019-100147.Peer-Reviewed Original ResearchBilateral superior frontal gyrusAlzheimer's diseaseSuperior frontal gyrusMiddle frontal gyrusFrontal gyrusInferior frontal gyrusResting-state functional magnetic resonance imagingZhejiang Provincial People's HospitalBrain functional alterationsMechanisms of ADLow-frequency fluctuationsBrain activityFunctional magnetic resonance imagingMagnetic resonance imagingResting-state fMRIALFF valuesPathophysiologic featuresPeople's HospitalInclusion criteriaDepressive symptomsFunctional alterationsPatientsResonance imagingLeft inferior frontal gyrusCore symptoms