2021
Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia.
Shi J, Chen N, Wang Z, Wang F, Tan Y, Tan S, Tong J, An H, Guo X, Zuo L, Wang X, Yang F, Luo X. Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia. EC Psychology And Psychiatry 2021, 10: 11-23. PMID: 34368810, PMCID: PMC8341072.Peer-Reviewed Original ResearchMRNA expressionSmoking behaviorSingle nucleotide polymorphismsGABAergic receptor expressionMale Chinese patientsHuman brainPromoter single nucleotide polymorphismsBeta 3 subunitSignificant mRNA expressionChinese patientsReceptor expressionHealthy volunteersNicotine dependenceSmokingSchizophreniaBrainReceptor genePatientsDopaminergicRegulatory effectsSubunit polymorphismsTotal sampleCis-acting regulatory effectsNucleotide polymorphismsCommon genetic basis
2015
A functional polymorphism in the interleukin-1beta and severity of nicotine dependence in male schizophrenia: A case-control study
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Rao W, Yu Q, Kou C, Allen M, Correll CU, Wu J, Soares JC. A functional polymorphism in the interleukin-1beta and severity of nicotine dependence in male schizophrenia: A case-control study. Journal Of Psychiatric Research 2015, 64: 51-58. PMID: 25858413, DOI: 10.1016/j.jpsychires.2015.03.015.Peer-Reviewed Original ResearchConceptsT polymorphismNicotine dependenceCase-control studyIL-1 participatesNegative Syndrome ScaleSignificant differencesMale smokersMale patientsSmoking statusLung diseaseMale schizophreniaSmoking indexIL-1betaChronic schizophreniaFagerstrom TestHealthy controlsInterleukin-1betaC genotypeSmokersT genotypePatientsSmoking behaviorControl groupMale controlsSyndrome Scale
2012
Association of functional dopamine-beta-hydroxylase (DBH) 19bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers
Zhang XY, Chen D, Xiu MH, Hui L, Liu H, Luo X, Zuo L, Zhang H, Kosten TA, Kosten TR. Association of functional dopamine-beta-hydroxylase (DBH) 19bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. Schizophrenia Research 2012, 141: 48-53. PMID: 22871345, DOI: 10.1016/j.schres.2012.07.011.Peer-Reviewed Original ResearchConceptsSchizophrenic smokersHealthy controlsNicotine dependenceDrug rewardLower FTND scoresIns/ins genotypeDopamine beta‐hydroxylase polymorphismInsertion/deletion polymorphismCase-control designClinician-administered questionnairesSmoking severityMale schizophreniaFagerstrom TestFTND scoreSmoking behaviorModel groupNicotine useSchizophrenia patientsSmokersDel genotypeMale controlsPatientsDel polymorphismFunctional polymorphismsIns genotype
2010
Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior
Han S, Gelernter J, Luo X, Yang BZ. Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior. Biological Psychiatry 2010, 67: 12-19. PMID: 19819424, PMCID: PMC2975396, DOI: 10.1016/j.biopsych.2009.08.028.Peer-Reviewed Original ResearchConceptsSmoking behaviorGenome-wide suggestive linkageGenome-wide linkage scanSubgroup analysisGenome scan resultsScan resultsLinkage scanSuggestive linkageGenome-wide significant linkageFagerstrom TestCandidate gene identificationNicotine dependenceRe-sequencing studiesMeta-AnalysisSecondary analysis