2020
Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Hong L, Tan Y. Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study. Neuroscience Letters 2020, 742: 135548. PMID: 33279570, DOI: 10.1016/j.neulet.2020.135548.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaRight postcentral gyrusInferior frontal gyrusPostcentral gyrusSchizophrenic patientsWhole brain resting-state functional connectivity (rsFC) analysisMotor circuitsLeft primary motor cortexRight supplementary motor areaFunctional connectivityPathogenesis of TDResting-state fMRI studyResting-state functional connectivity analysisFrontal gyrusAIMS total scoreLeft triangular partPrimary motor cortexAbnormal functional connectivityRight superior parietal lobuleSupplementary motor areaNegative Syndrome ScaleNon-TD groupSuperior parietal lobuleBilateral parietal cortex
2018
Resting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe
Zhang P, Li Y, Fan F, Li CR, Luo X, Yang F, Yao Y, Tan Y. Resting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe. Neuroscience 2018, 385: 237-245. PMID: 29909076, DOI: 10.1016/j.neuroscience.2018.06.014.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleMiddle occipital gyrusRight calcarine sulcusTardive dyskinesiaBrain activity changesClinical parametersLeft middle occipital gyrusSchizophrenic patientsCalcarine sulcusOccipital lobeSeverity of TDAIMS total scoreDecreased brain activityFractional amplitudeResting-state functional magnetic resonance imaging (fMRI) dataResting-state brain activityLow-frequency fluctuationsNegative Syndrome ScaleBrain activityActivity changesConstructional scoresTD groupTD patientsHealthy controlsMagnetic resonance imaging data
2016
Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjects
2013
Cognitive Function, Plasma MnSOD Activity, and MnSOD Ala-9Val Polymorphism in Patients With Schizophrenia and Normal Controls
Zhang XY, Chen D, Xiu MH, Yang FD, Tan Y, Luo X, Zuo L, Kosten TA, Kosten TR. Cognitive Function, Plasma MnSOD Activity, and MnSOD Ala-9Val Polymorphism in Patients With Schizophrenia and Normal Controls. Schizophrenia Bulletin 2013, 40: 592-601. PMID: 23588476, PMCID: PMC3984504, DOI: 10.1093/schbul/sbt045.Peer-Reviewed Original ResearchConceptsAla-9Val polymorphismNormal controlsCognitive impairmentMnSOD activityAla allele carriersChronic schizophrenic patientsMitochondrial enzyme manganese superoxide dismutaseNegative Syndrome ScaleEnzyme manganese superoxide dismutaseHealthy controlsManganese superoxide dismutaseAllele carriersExcessive reactive oxygen speciesSchizophrenic patientsSchizophrenic inpatientsSyndrome ScaleCognitive deficitsNeuropsychological StatusCognitive functionPatients' psychopathologyRepeatable BatteryPatientsSchizophreniaTotal scoreReactive oxygen species
2012
Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls
Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, Kosten TA, Kosten TR. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Human Genetics 2012, 131: 1187-1195. PMID: 22362486, PMCID: PMC3671849, DOI: 10.1007/s00439-012-1150-x.Peer-Reviewed Original ResearchConceptsBDNF Val66Met polymorphismBDNF levelsRBANS total scoreHealthy controlsSchizophrenic patientsVal66Met polymorphismHippocampal-dependent cognitive functionsCognitive deficitsBrain-derived neurotrophic factor (BDNF) geneTotal scoreBDNF serum levelsBDNF Val66Met gene polymorphismPeripheral BDNF levelsSerum BDNF levelsMet variantNeurotrophic factor geneNegative Syndrome ScaleSerum BDNFSerum levelsPatient groupNormal controlsSchizophrenic inpatientsGene polymorphismsSyndrome ScaleCognitive impairment