2021
Kynurenine metabolism and metabolic syndrome in patients with schizophrenia
Zhang P, Huang J, Gou M, Zhou Y, Tong J, Fan F, Cui Y, Luo X, Tan S, Wang Z, Yang F, Tian B, Li CR, Hong LE, Tan Y. Kynurenine metabolism and metabolic syndrome in patients with schizophrenia. Journal Of Psychiatric Research 2021, 139: 54-61. PMID: 34034146, DOI: 10.1016/j.jpsychires.2021.05.004.Peer-Reviewed Original ResearchConceptsMetabolic syndromeKP metabolitesMS scorePathogenesis of MSKynurenine pathway metabolismRegression analysisKynurenine metabolismPatient groupHealthy controlsMultiple linear regression analysisSchizophrenia patientsLinear regression analysisPathway metabolismPatientsContributory roleSchizophreniaHigh nicotinamide adenine dinucleotideNicotinamide adenine dinucleotideMS factorsPotential rolePartial correlation analysisScoresMultiple regression analysisSyndromePathogenesis
2018
Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults
Wang K, Liu Y, Ouedraogo Y, Wang N, Xie X, Xu C, Luo X. Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults. Journal Of Psychiatric Research 2018, 100: 113-120. PMID: 29518578, PMCID: PMC6329582, DOI: 10.1016/j.jpsychires.2018.02.022.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug useEarly alcoholDepressive disorderOdds ratioAdult major depressive disorderMultiple logistic regression analysisConfidence intervalsMultiple logistic regressionLogistic regression analysisOverall prevalenceTobacco useUS adultsSignificant associationLogistic regressionRegression analysisNational surveyDisordersAdultsPotential factorsScoresAssociationTobaccoYearsPast year
2017
Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol
Chen Y, Xu C, Harirforoosh S, Luo X, Wang KS. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal Of Psychiatric Research 2017, 96: 65-72. PMID: 28987514, PMCID: PMC6195678, DOI: 10.1016/j.jpsychires.2017.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCerebellumCholesterolComputer SimulationFamilyGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiddle AgedNeoplasmsPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2ConceptsRisk of ADRisk of cancerAlzheimer's diseaseAAO of ADSingle nucleotide polymorphismsTotal cholesterol levelsMultiple logistic regressionLDL cholesterolTotal cholesterolCholesterol levelsAD patientsCancer riskMultiple linear regression analysisLinear regression analysisNeuropsychiatric disordersLogistic regressionDiseaseCancerWilcoxon testExpression levelsRiskRegression analysisGene expression levelsHuman brainGenetic variants
2015
Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations
Wang KS, Zuo L, Pan Y, Xie C, Luo X. Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. Journal Of Psychiatric Research 2015, 71: 1-7. PMID: 26522866, DOI: 10.1016/j.jpsychires.2015.09.008.Peer-Reviewed Original ResearchConceptsAlcohol dependenceSingle nucleotide polymorphismsMultiple logistic regression analysisMarshfield sampleRisk of obesityLogistic regression analysisCentral nervous systemGenetic variantsObesityNervous systemCommon genetic variantsAlcohol addictionCaucasian populationRegression analysisPLINK softwareGenetic associationV geneFirst evidenceAssociationCaucasian samplesGenetic componentPopulation
2014
Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia.
Wang KS, Zuo L, Owusu D, Pan Y, Luo X. Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia. Journal Of Schizophrenia Research 2014, 1 PMID: 27570842, PMCID: PMC4996122.Peer-Reviewed Original ResearchRisk of schizophreniaProstate cancerSingle nucleotide polymorphismsType 2 diabetesLogistic regression analysisJAZF1 geneReduced incidenceEpidemiological studiesSCZ patientsNext best signalG haplotypeSignificant associationSchizophreniaC haplotypeCancerRegression analysisGenetic variantsPLINK softwareRiskGenetic associationAssociationHaplotype analysisGenetic backgroundPatientsDiabetes
2013
Genetic Variants in the Fat Mass- and Obesity-Associated (FTO) Gene are Associated with Alcohol Dependence
Wang L, Liu X, Luo X, Zeng M, Zuo L, Wang KS. Genetic Variants in the Fat Mass- and Obesity-Associated (FTO) Gene are Associated with Alcohol Dependence. Journal Of Molecular Neuroscience 2013, 51: 416-424. PMID: 23771786, DOI: 10.1007/s12031-013-0044-2.Peer-Reviewed Original ResearchConceptsAlcohol dependenceSingle nucleotide polymorphismsFat massType 2 diabetesLogistic regression analysisObesity-associated (FTO) geneObesity-Associated GeneAlcohol consumptionJoint interventionsFTO geneObesityRegression analysisGenetic variantsPLINK softwareAssociationAlcoholism (COGA) sampleSage samplesHaplotype analysisCollaborative studyCaucasian samplesSingle marker analysisCOGA sampleDiabetes
2007
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry 2007, 13: 531-543. PMID: 17622222, PMCID: PMC3163084, DOI: 10.1038/sj.mp.4002035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismCase-Control StudiesCocaine-Related DisordersEuropeExonsFemaleGenetic Predisposition to DiseaseHaplotypesHeroin DependenceHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Opioid, deltaReceptors, Opioid, kappaRiskSubstance-Related DisordersUnited StatesConceptsLogistic regression analysisSingle nucleotide polymorphismsRegression analysisTag single nucleotide polymorphismsOPRD1 variantsG alleleC alleleDrug dependenceSignificant associationRisk effectsEuropean AmericansStratification artifactSignificant differencesPositive associationHaplotypic associationsMultiple testingAssociationOPRK1OPRD1Dependence riskSDCNR1 Variation Modulates Risk for Drug and Alcohol Dependence
Zuo L, Kranzler HR, Luo X, Covault J, Gelernter J. CNR1 Variation Modulates Risk for Drug and Alcohol Dependence. Biological Psychiatry 2007, 62: 616-626. PMID: 17509535, DOI: 10.1016/j.biopsych.2006.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanCase-Control StudiesChromosome MappingComorbidityFemaleGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMalePolymorphism, Single NucleotideReceptor, Cannabinoid, CB1Regression AnalysisRisk FactorsSubstance-Related DisordersWhite PeopleConceptsCannabinoid receptor 1Substance dependenceHealthy control subjectsHuman cannabinoid receptor 1Control subjectsSD patientsT genotypeProtective allelesAlcohol dependenceReceptor 1Disease riskModulate riskCNR1 geneCNR1 variationInitial reportCase-control sampleLarge case-control sampleRegression analysisRiskStrong genetic effectsMarkersSignificant interaction effectMultiple markersAncestry informative markersSNP8
2005
ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. Pharmacogenetics And Genomics 2005, 15: 755-768. PMID: 16220108, DOI: 10.1097/01.fpc.0000180141.77036.dc.Peer-Reviewed Original ResearchConceptsAlcohol dependenceDrug dependenceSingle nucleotide polymorphismsDiagnosis of alcoholLogistic regression analysisUnrelated healthy controlsUnrelated casesRigorous study designsGene variationRelative risk analysisHaplotype-based haplotype relative riskHealthy controlsRelative riskHaplotype relative risk analysisDisequilibrium testCase-control association analysisInitial studyStudy designTransmission disequilibrium testStrong associationHaplotype relative riskRegression analysisMarkersAffected offspringPresent study