2019
Effects of Antipsychotic Treatment on S100B and Oxidative Stress in Patients with Schizophrenia
Wang X, Bian Y, Liu L, Wu Y, Yang F, Li X, Han X, Tian L, Luo X, Chen S, Wang Z, Tan Y, Li Y. Effects of Antipsychotic Treatment on S100B and Oxidative Stress in Patients with Schizophrenia. Global Clinical And Translational Research 2019, 120-127. DOI: 10.36316/gcatr.01.0018.Peer-Reviewed Original ResearchDrug-naive patientsLevels of S100BFirst-episode drug-naive patientsAntipsychotic treatmentTotal oxidative statusAcute-phase schizophreniaLevels of malondialdehydeAcute phasePatient groupOxidative stressAcute phase patientsDSM-IV diagnostic criteriaAntipsychotic treatment effectsPANSS negative scoresNegative Syndrome ScaleRandom-effects modelSerum S100BPhase patientsSerum levelsDiagnostic criteriaPatientsSyndrome ScaleS100BRisperidoneOxidative statusPlasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia
Xie T, Li Q, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Tan Y. Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia. Cognitive Neurodynamics 2019, 13: 357-365. PMID: 31354881, PMCID: PMC6624222, DOI: 10.1007/s11571-019-09530-3.Peer-Reviewed Original ResearchAttention/vigilanceSpeed of processingTotal antioxidant statusFirst-episode drug-naïve patientsDrug-naïve patientsCognitive impairmentCognitive deficitsSchizophrenia (MATRICS) Consensus Cognitive BatteryMCCB total scoreConsensus Cognitive BatteryHealthy controlsAntioxidant statusPlasma total antioxidant statusSex-matched healthy controlsOxidative stressPlasma TAS levelsPathophysiology of schizophreniaCognitive batteryStroop testNegative Syndrome ScaleReactive oxygen species-induced oxidative damageTreatment researchPsychopathological symptomsFEDN patientsHealthy subjects
2016
Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury
Cao Y, Gao Y, Xu S, Bao J, Lin Y, Luo X, Wang Y, Luo Q, Jiang J, Neale JH, Zhong C. Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury. BMC Neuroscience 2016, 17: 15. PMID: 27091009, PMCID: PMC4836105, DOI: 10.1186/s12868-016-0251-1.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryWild-type miceBrain injuryKnockout miceNeuroprotective efficacyType miceImpact injuryOxidative stressCortical impact injuryInjury-induced increaseBcl-2/Bax ratioGene knockout miceGlutathione peroxidase activityCerebral cortexCortical apoptosisKO miceCytosolic cytochrome c levelsConclusionsThese dataN-acetylaspartylglutamateSynaptic releaseTUNEL-positive nucleiAnimal modelsExtracellular levelsCytochrome c levelsGlutathione levels