2023
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDiseaseA significant, functional and replicable risk KTN1 variant block for schizophrenia
Mao Q, Lin X, Yin Q, Liu P, Zhang Y, Qu S, Xu J, Cheng W, Luo X, Kang L, Taximaimaiti R, Zheng C, Zhang H, Wang X, Ren H, Cao Y, Lin J, Luo X. A significant, functional and replicable risk KTN1 variant block for schizophrenia. Scientific Reports 2023, 13: 3890. PMID: 36890161, PMCID: PMC9995530, DOI: 10.1038/s41598-023-27448-z.Peer-Reviewed Original ResearchMale-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain
Luo X, Lin X, Ide J, Luo X, Zhang Y, Xu J, Wang L, Chen Y, Cheng W, Zheng J, Wang Z, Yu T, Taximaimaiti R, Jing X, Wang X, Cao Y, Tan Y, Li C. Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain. Child And Adolescent Psychiatry And Mental Health 2023, 17: 4. PMID: 36609385, PMCID: PMC9824933, DOI: 10.1186/s13034-022-00536-0.Peer-Reviewed Original ResearchGray matter volumeAttention deficit hyperactivity disorderTotal intracranial volumeSubcortical gray matter volumesMRNA expressionBasal gangliaEuropean cohortABCD cohortMatter volumeCerebral gray matter volumeRisk of ADHDPathogenesis of ADHDGene-wide association studyAmygdala gray matter volumeRegulatory effectsDeficit hyperactivity disorderBrain cohortSubcortical regionsBrain regionsIntracranial volumeCohortSubcortical structuresADHD risk allelesADHD riskHyperactivity disorder
2019
Choroid Plexus Enlargement and Allostatic Load in Schizophrenia
Zhou Y, Huang J, Zhang P, Fan F, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yuan Y, Yang F, Savransky A, Ryan M, Goldwaser E, Chiappelli J, Rowland L, Kochunov P, Tan Y, Hong L. Choroid Plexus Enlargement and Allostatic Load in Schizophrenia. Schizophrenia Bulletin 2019, 46: 722-731. PMID: 31603232, PMCID: PMC7147577, DOI: 10.1093/schbul/sbz100.Peer-Reviewed Original ResearchConceptsChoroid plexusHigher allostatic loadAllostatic loadSex-matched healthy controlsCentral nervous system abnormalitiesFirst-episode schizophrenia patientsChoroid plexus enlargementNervous system abnormalitiesTotal intracranial volumeHealthy controlsThalamus volumeLateral ventricleNeuroendocrine biomarkersSystem abnormalitiesAmygdala volumeSchizophrenia patientsBrain disordersInitial stabilizationIntracranial volumeStructural biomarkersPlexusBrain structuresPatientsSchizophreniaGroup differences