2024
The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia
Guo X, Luo X, Huang X, Zhang Y, Ji J, Wang X, Wang K, Wang J, Pan X, Chen B, Tan Y, Luo X. The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia. Anatolian Journal Of Psychiatry 2024, 25: 413-420. PMID: 39148597, PMCID: PMC11322729, DOI: 10.5152/alphapsychiatry.2024.241616.Peer-Reviewed Original ResearchGray matter volumeAssociated with volumetric reductionsBasal gangliaSuperior frontal cortexDevelopment of schizophreniaSingle-nucleotide polymorphismsRisk of schizophreniaNucleus accumbensFrontal cortexPosterior cingulateMatter volumeInsular cortexBrain areasSchizophreniaSubcortical nucleiVolumetric reductionCortexPutamenCortical areasIndependent samplesRisk allelesSignificance of variantsRegulatory regionsMRNA expressionGenome-wide association studies
2023
A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study
Guo X, Wang S, Lin X, Wang Z, Dou Y, Cao Y, Zhang Y, Luo X, Kang L, Yu T, Wang Z, Tan Y, Gao S, Zheng H, Zhao F, Wang H, Wang K, Xie F, Chen W, Luo X. A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study. Psychiatric Genetics 2023, 33: 182-190. PMID: 37706495, PMCID: PMC10502955, DOI: 10.1097/ypg.0000000000000344.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain regionsMRNA expressionSubcortical structuresPathogenesis of schizophreniaRisk variantsRisk genesMultiple brain regionsCortical surface areaPotential regulatory effectsHealthy subjectsMatter volumeSignificant associationCortical regionsSame effect directionSchizophreniaNovel risk variantsSchizophrenia risk allelesAssociation studiesCACNA1CIndependent samplesRegulatory effectsNumerous genome-wide association studiesTop risk genesValidation study