2023
A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study
Guo X, Wang S, Lin X, Wang Z, Dou Y, Cao Y, Zhang Y, Luo X, Kang L, Yu T, Wang Z, Tan Y, Gao S, Zheng H, Zhao F, Wang H, Wang K, Xie F, Chen W, Luo X. A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study. Psychiatric Genetics 2023, 33: 182-190. PMID: 37706495, PMCID: PMC10502955, DOI: 10.1097/ypg.0000000000000344.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain regionsMRNA expressionSubcortical structuresPathogenesis of schizophreniaRisk variantsRisk genesMultiple brain regionsCortical surface areaPotential regulatory effectsHealthy subjectsMatter volumeSignificant associationCortical regionsSame effect directionSchizophreniaNovel risk variantsSchizophrenia risk allelesAssociation studiesCACNA1CIndependent samplesRegulatory effectsNumerous genome-wide association studiesTop risk genesValidation studySpatial Multiomics Analysis in Psychiatric Disorders.
Mao Q, Huang S, Luo X, Liu P, Wang X, Wang K, Zhang Y, Chen B, Luo X. Spatial Multiomics Analysis in Psychiatric Disorders. EC Psychology And Psychiatry 2023, 12: 1-5. PMID: 37424930, PMCID: PMC10328214.Peer-Reviewed Original ResearchPsychiatric disordersAlzheimer's diseaseCommon psychiatric disordersCertain brain regionsRisk genesMiddle temporal gyrusMultiomics analysisAutism spectrum disorderAD pathologyDisease progressionOlfactory bulbSpectrum disorderMouse modelPsychiatric diseasesHuman hippocampusBrain regionsNeuropsychiatric disordersTemporal gyrusLiterature searchAid diagnosisDisordersTranscriptional signatureDiseaseHippocampusSpatial transcriptomic analysisAssociation of lesion location with post-stroke depression in China: a systematic review and meta-analysis.
Luo X, Fang W, Ji J, Zhang Y, Garcia-Milian R, Wang Z, Tan Y, Wang S, Wang X, Guo X, Luo X. Association of lesion location with post-stroke depression in China: a systematic review and meta-analysis. EC Psychology And Psychiatry 2023, 12: 34-45. PMID: 36913221, PMCID: PMC9997510.Peer-Reviewed Original ResearchPost-stroke depressionIncidence of PSDType of strokeCerebral cortexLesion locationOccurrence of PSDBrain lesion locationLeft hemisphereMental health conditionsDifferent brain regionsHemorrhagic strokeChinese patientsHigh riskAnterior cortexPSD incidenceSystematic reviewBrain regionsPSD occurrenceStrokePosterior cortexCortexHealth conditionsSystematic searchRight hemisphereIncidenceMale-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain
Luo X, Lin X, Ide J, Luo X, Zhang Y, Xu J, Wang L, Chen Y, Cheng W, Zheng J, Wang Z, Yu T, Taximaimaiti R, Jing X, Wang X, Cao Y, Tan Y, Li C. Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain. Child And Adolescent Psychiatry And Mental Health 2023, 17: 4. PMID: 36609385, PMCID: PMC9824933, DOI: 10.1186/s13034-022-00536-0.Peer-Reviewed Original ResearchGray matter volumeAttention deficit hyperactivity disorderTotal intracranial volumeSubcortical gray matter volumesMRNA expressionBasal gangliaEuropean cohortABCD cohortMatter volumeCerebral gray matter volumeRisk of ADHDPathogenesis of ADHDGene-wide association studyAmygdala gray matter volumeRegulatory effectsDeficit hyperactivity disorderBrain cohortSubcortical regionsBrain regionsIntracranial volumeCohortSubcortical structuresADHD risk allelesADHD riskHyperactivity disorder
2022
Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariates
2021
An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia
Wang Z, Chen W, Cao Y, Dou Y, Fu Y, Zhang Y, Luo X, Kang L, Liu N, Shi YS, Li CR, Xu Y, Guo X, Luo X. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 385-397. PMID: 33938268, DOI: 10.1177/00048674211009595.Peer-Reviewed Original ResearchConceptsMessenger RNA expressionGray matter volumeMatter volumeSingle nucleotide polymorphismsRisk allelesRNA expressionPathogenesis of schizophreniaSingle nucleotide polymorphism (SNP) rs1006737Isthmus cingulate cortexMinor allele ARisk single nucleotide polymorphismsBrain cohortCingulate cortexBrain regionsCortical regionsSubcortical structuresSchizophreniaRs1006737Allele ARegulatory effectsRisk genesSignificant risk genesCohortCortexAfrican American sample
2017
Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease
Wang KS, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Journal Of Neuroimmunology 2017, 310: 60-65. PMID: 28778446, PMCID: PMC6167010, DOI: 10.1016/j.jneuroim.2017.06.010.Peer-Reviewed Original ResearchConceptsRisk of ADAlzheimer's diseaseSingle nucleotide polymorphismsAAO of ADHuman brain regionsNervous system developmentApoE expressionOnset (AAO) of ADBrain regionsDiseaseSignificant expressionRiskMarker analysisGenetic variantsAssociationFamily-based association analysisHaplotype analysisPresent studyEquation statisticsAgeFirst studyOnsetFamily-based associationFamily-based sampleExpression
2009
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
Wang F, Jiang T, Sun Z, Teng SL, Luo X, Zhu Z, Zang Y, Zhang H, Yue W, Qu M, Lu T, Hong N, Huang H, Blumberg HP, Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal Of Psychiatry And Neuroscience 2009, 34: 181-6. PMID: 19448847, PMCID: PMC2674970.Peer-Reviewed Original ResearchConceptsAnterior cingulumFractional anisotropyHealthy controlsBrain regionsDiagnosis of schizophreniaDiffusion tensorWhite matter connectivityHealthy menWhite matter structuresT carriersMyelin integrityTT subgroupPatientsProminent involvementT alleleReciprocal connectionsAnterior componentC alleleCingulum bundleSchizophrenia groupGenetic susceptibilityCingulum fractional anisotropyNeuregulin1SchizophreniaSmall sample size