2020
Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder
Wang W, Liu Y, Luo S, Guo X, Luo X, Zhang Y. Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder. Brain And Behavior 2020, 10: e01885. PMID: 33047489, PMCID: PMC7749616, DOI: 10.1002/brb3.1885.Peer-Reviewed Original ResearchConceptsBDNF Met/Met genotypeMet/Met genotypeLower BDNF plasma levelsPanic disorderCognitive impairmentMet genotypeMontreal Cognitive AssessmentStroop interferenceVerbal learningNeurocognitive measuresCognitive performanceBDNF plasma levelsMoCA dataCognitive AssessmentAnxiety ScaleBDNF Val66Met polymorphismVal/ValPanic symptomsLower scoresPD patientsHamilton Anxiety ScaleProcessing domainPlasma levelsHealthy controlsModerate positive correlation
2014
Smoking and BDNF Val66Met polymorphism in male schizophrenia: A case-control study
Zhang XY, Chen DC, Tan YL, Luo X, Zuo L, Lv MH, Shah NN, Zunta-Soares GB, Soares JC. Smoking and BDNF Val66Met polymorphism in male schizophrenia: A case-control study. Journal Of Psychiatric Research 2014, 60: 49-55. PMID: 25455509, DOI: 10.1016/j.jpsychires.2014.09.023.Peer-Reviewed Original ResearchConceptsVal/Val genotypeBDNF Val66Met polymorphismHealthy controlsNicotine dependenceVal66Met polymorphismVal genotypeSchizophrenia patientsChronic male schizophrenia patientsMet alleleBDNF Val66Met gene polymorphismBDNF Val66Met genotypePANSS negative symptomsHigher FTND scoresCase-control studyMale schizophrenia patientsNegative Syndrome ScaleChinese Han populationCase-control designVal66Met genotypeMore hospitalizationsPatient groupSmoking indexMale schizophreniaFagerstrom TestHigh HSI scores
2012
BDNF Val66Met Variant and Smoking in a Chinese Population
Zhang XY, Chen DC, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. BDNF Val66Met Variant and Smoking in a Chinese Population. PLOS ONE 2012, 7: e53295. PMID: 23285275, PMCID: PMC3532294, DOI: 10.1371/journal.pone.0053295.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF Val66Met gene polymorphismBDNF Val66Met polymorphismSerum levelsVal66Met polymorphismGene polymorphismsChinese populationBDNF serum levelsSerum BDNF levelsVal/Val genotypeNumber of cigarettesHealthy male volunteersChinese male populationNicotine dependence scoresNeurotrophic factor familyBDNF Val66Met variantBDNF levelsNeurotrophic factorFagerstrom TestBDNF geneMale volunteersLarge cohortNicotine dependenceVal66Met variantNicotine addictionCognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls
Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, Kosten TA, Kosten TR. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Human Genetics 2012, 131: 1187-1195. PMID: 22362486, PMCID: PMC3671849, DOI: 10.1007/s00439-012-1150-x.Peer-Reviewed Original ResearchConceptsBDNF Val66Met polymorphismBDNF levelsRBANS total scoreHealthy controlsSchizophrenic patientsVal66Met polymorphismHippocampal-dependent cognitive functionsCognitive deficitsBrain-derived neurotrophic factor (BDNF) geneTotal scoreBDNF serum levelsBDNF Val66Met gene polymorphismPeripheral BDNF levelsSerum BDNF levelsMet variantNeurotrophic factor geneNegative Syndrome ScaleSerum BDNFSerum levelsPatient groupNormal controlsSchizophrenic inpatientsGene polymorphismsSyndrome ScaleCognitive impairment