2024
The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia-A Gene-Environment Interaction Study.
Wang X, Zhong C, Ma X, Metayer C, Mancuso N, Gauderman W, Wiemels J. The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia-A Gene-Environment Interaction Study. Cancer Epidemiology Biomarkers & Prevention 2024, of1-of8. PMID: 39495115, DOI: 10.1158/1055-9965.epi-24-1037.Peer-Reviewed Original ResearchPrenatal tobacco exposureTobacco exposureGene-environment interaction studiesNon-Latino white childrenAcute lymphoblastic leukemia riskChildhood ALL riskRepair genesGene-environment interactionsAcute lymphoblastic leukemiaStatistically significant interactionPotential risk factorsDNA repair genesTobacco smokeLatino childrenPediatric oncologyALL riskTargeted preventionWhite childrenLogistic regressionEpidemiological studiesEnvironmental exposuresRisk factorsTobaccoGenotype dataSignificant interaction
2023
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.
Zhong C, Li S, Arroyo K, Morimoto L, de Smith A, Metayer C, Ma X, Kogan S, Gauderman W, Wiemels J. Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1707-1715. PMID: 37773025, DOI: 10.1158/1055-9965.epi-23-0258.Peer-Reviewed Original ResearchConceptsMaternal tobacco exposureAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaTobacco exposureLymphoblastic leukemiaLarge population-based studyPopulation-based studyEffects of tobaccoPrenatal tobacco exposureAryl hydrocarbon receptor repressor geneMode of deliverySelf-reported smokingIndividual-level risk factorsGenetic variantsPolygenetic risk scoresYear of birthAHRR hypomethylationSubsequent childhoodMaternal exposureGestational ageRisk factorsTobacco smokeRisk scoreBiological markersBlood spots