2022
Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study.
Gubitosi-Klug RA, Braffett BH, Bebu I, Johnson ML, Farrell K, Kenny D, Trapani VR, Meadema-Mayer L, Soliman EZ, Pop-Busui R, Lachin JM, Bergenstal RM, Tamborlane WV. Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study. Diabetes Care 2022, 45: 659-665. PMID: 35076697, PMCID: PMC8918229, DOI: 10.2337/dc21-0629.Peer-Reviewed Original ResearchConceptsType 1 diabetesContinuous glucose monitoringInsulin pumpDCCT/EDIC studyComplications Trial/EpidemiologyGlucose monitoringPercent timeRelevant clinical goalsYears of ageMean sensor glucoseSubset of adultsComplications StudyEDIC studyEntire recording periodOlder patientsGlycemic excursionsDiabetes controlSignificant hypoglycemiaDiabetes InterventionsYears durationHypoglycemiaSensor glucoseClinical goalsHyperglycemic excursionsType 1
2020
Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes
DuBose SN, Li Z, Sherr JL, Beck RW, Tamborlane WV, Shah VN. Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes. Journal Of Diabetes Science And Technology 2020, 15: 593-599. PMID: 32064911, PMCID: PMC8120054, DOI: 10.1177/1932296820905904.Peer-Reviewed Original ResearchConceptsEffects of exerciseSensor glucose levelsHealthy individualsResistance exerciseNadir glucoseGlucose levelsNonobese body mass indexT1D Exchange Clinic NetworkPeak postprandial glucoseBody mass indexGlucose concentrationTime of mealsNadir glucose concentrationsConsumption of alcoholMass indexPostprandial glucoseNonexercise dayAerobic exerciseExercise dayClinic networkMean changeFuture therapiesDiabetesDexcom G6Glucose monitor data
2019
International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium–Glucose Cotransporter (SGLT) Inhibitors
Danne T, Garg S, Peters AL, Buse JB, Mathieu C, Pettus JH, Alexander CM, Battelino T, Ampudia-Blasco FJ, Bode BW, Cariou B, Close KL, Dandona P, Dutta S, Ferrannini E, Fourlanos S, Grunberger G, Heller SR, Henry RR, Kurian MJ, Kushner JA, Oron T, Parkin CG, Pieber TR, Rodbard HW, Schatz D, Skyler JS, Tamborlane WV, Yokote K, Phillip M. International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium–Glucose Cotransporter (SGLT) Inhibitors. Diabetes Care 2019, 42: 1147-1154. PMID: 30728224, PMCID: PMC6973545, DOI: 10.2337/dc18-2316.Peer-Reviewed Original ResearchConceptsType 1 diabetesSodium-glucose cotransporter inhibitorsDiabetic ketoacidosisCotransporter inhibitorsSGLT inhibitorsNear-normal blood glucose levelsOral antidiabetes medicationsBlood glucose levelsAntidiabetes medicationsInhibitor useBlood pressureAbsolute riskMild hyperglycemiaDKA riskGlycemic variabilityConsensus reportGlucose levelsBody weightDrug AdministrationDiabetesType 1U.S. FoodMedical communityKetoacidosisInternational consensus
2017
Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial
Galderisi A, Facchinetti A, Steil GM, Ortiz-Rubio P, Cavallin F, Tamborlane WV, Baraldi E, Cobelli C, Trevisanuto D. Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial. Pediatrics 2017, 140: e20171162. PMID: 28916591, DOI: 10.1542/peds.2017-1162.Peer-Reviewed Original ResearchConceptsVery preterm infantsGlucose infusion rateContinuous glucose monitoringPreterm infantsCGM groupPercentage of timeEuglycemic rangeSevere hyperglycemiaSevere hypoglycemiaGlycemic variabilityGlucose monitoringCare blood glucose monitoringUse of CGMPoor neurologic outcomeImpaired glucose controlBlood glucose monitoringBlood glucose determinationNeurologic outcomeSecondary outcomesInsulin titrationPrimary outcomeWeeks' gestationControlled TrialsGlucose controlBirth weight
2012
The Alteration of Aspart Insulin Pharmacodynamics When Mixed With Detemir Insulin
Cengiz E, Swan KL, Tamborlane WV, Sherr JL, Martin M, Weinzimer SA. The Alteration of Aspart Insulin Pharmacodynamics When Mixed With Detemir Insulin. Diabetes Care 2012, 35: 690-692. PMID: 22374642, PMCID: PMC3308292, DOI: 10.2337/dc11-0732.Peer-Reviewed Original ResearchConceptsType 1 diabetesDetemir insulinInsulin analoguesInsulin pharmacodynamicsRapid-acting insulin analoguesRapid-acting insulinTime-action profileEuglycemic glucose clampCommon regimenRandomized studyDaily injectionsUnits/Glucose clampInsulin actionSame syringePharmacodynamicsAspartInsulinDiabetesRandom orderAdverse effectsSeparate injectionsAction studiesInjectionMixed injection
2003
Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia
Enoksson S, Caprio SK, Rife F, Shulman GI, Tamborlane WV, Sherwin RS. Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 1503-1511. PMID: 12679430, DOI: 10.1210/jc.2002-021013.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdrenergic beta-AgonistsAdultBlood GlucoseDiabetes Mellitus, Type 1EpinephrineFatty Acids, NonesterifiedFemaleGlucoseGlucose Clamp TechniqueGlycerolHomeostasisHumansHypoglycemiaInsulinLactic AcidLipolysisMaleMuscle, SkeletalNorepinephrineReceptors, Adrenergic, beta-2TerbutalineConceptsT1DM patientsControl subjectsGlucose disposalAdipose tissueType 1 diabetes mellitus patientsWhole-body glucose disposalWhole-body glucose useSkeletal muscleDiabetes mellitus patientsGlucagon secretory responsesRisk of hypoglycemiaPlasma epinephrine concentrationSeverity of hypoglycemiaAdipose tissue lipolysisMajor target tissuesHyperinsulinemic euglycemiaAgonist terbutalineAdrenomedullary responseMellitus patientsNondiabetic subjectsDeficient releasePlasma epinephrinePlasma glucoseInsulin infusionCatecholamine secretionLocal Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation
Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation. Diabetes 2003, 52: 663-666. PMID: 12606506, DOI: 10.2337/diabetes.52.3.663.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesVentromedial hypothalamusHormone responseSprague-Dawley ratsGlucose-sensing mechanismHypoglycemic counterregulationSystemic hypoglycemiaHormonal suppressionLactate perfusionApproximate fourfold increaseGlucose metabolismMicrodialysis perfusionGlucose perfusionHormonal responsesHypoglycemic plateauHypoglycemiaPerfusionL-lactateExogenous glucoseFourfold increaseGlucoseLactate
2002
Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity
Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S. Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity. New England Journal Of Medicine 2002, 346: 802-810. PMID: 11893791, DOI: 10.1056/nejmoa012578.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceType 2 diabetesC-peptide levelsGlucose toleranceGlucose tolerance testBeta-cell functionInsulin resistanceObese childrenInsulin levelsObese adolescentsGlucose levelsTwo-hour oral glucose tolerance testImpaired oral glucose toleranceOvert type 2 diabetesOral glucose tolerance testHomeostatic model assessmentOral glucose toleranceBody mass indexLevels of proinsulinBeta-cell failureIngestion of glucoseRatio of proinsulinSevere obesityMarked obesityChildhood obesity
1997
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. Journal Of Clinical Investigation 1997, 99: 361-365. PMID: 9006005, PMCID: PMC507804, DOI: 10.1172/jci119165.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamic nucleusMM D-glucoseControl groupGlucose perfusionHypoglycemic counterregulationSystemic hypoglycemiaNorepinephrine releaseGlucagon secretionCatecholamine concentrationsHypothalamic nucleiAwake ratsHormonal secretionControl animalsHypoglycemiaHormonal responsesPerfusionL glucoseCounterregulationD-glucoseGlucagonRatsSecretionGlucoseAnimalsGlucopenia
1996
Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children
Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV. Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children. Diabetologia 1996, 39: 1489-1497. PMID: 8960831, DOI: 10.1007/s001250050603.Peer-Reviewed Original ResearchConceptsObese groupHyperglycaemic clampInsulin resistanceObese preadolescentsInsulin actionGlucose-stimulated insulin levelsHigher insulin infusion ratesNon-oxidative glucose metabolismGlucose uptakeDuration of obesityGroup of obeseNon-obese subjectsBeta-cell functionDevelopment of obesityEuglycaemic hyperinsulinaemic clampSevere insulin resistanceInsulin infusion rateCross-sectional analysisOnset of pubertyAbility of insulinSevere obesityObese adultsObese childrenObese subjectsInsulin levels
1995
Central adiposity and its metabolic correlates in obese adolescent girls
Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, Shulman G, Tamborlane WV. Central adiposity and its metabolic correlates in obese adolescent girls. American Journal Of Physiology 1995, 269: e118-e126. PMID: 7631766, DOI: 10.1152/ajpendo.1995.269.1.e118.Peer-Reviewed Original ResearchConceptsObese adolescent girlsObese girlsInsulin secretionInsulin actionSubcutaneous abdominal fat depotsFree fatty acid levelsGlucose-stimulated insulin responseHip circumference ratioEuglycemic insulin clampHyperglycemic clamp techniqueBasal insulin secretionAbdominal fat depotsAdolescent girlsHepatic glucose productionFatty acid levelsMagnetic resonance imagingLean womenCentral adiposityInsulin dosesVisceral fatInsulin clampInsulin resistanceNonobese girlsGlucose disposalInsulin infusionInterstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle.
Maggs DG, Jacob R, Rife F, Lange R, Leone P, During MJ, Tamborlane WV, Sherwin RS. Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle. Journal Of Clinical Investigation 1995, 96: 370-377. PMID: 7615807, PMCID: PMC185209, DOI: 10.1172/jci118043.Peer-Reviewed Original ResearchConceptsAdipose tissueEuglycemic hyperinsulinemiaInterstitial glucoseSkeletal muscleInterstitial glycerol concentrationsInterstitial fluid concentrationsHuman skeletal muscleHuman quadriceps muscleInterstitial glycerolIntramuscular lipolysisReuptake blockadePlasma levelsPeripheral tissuesQuadriceps musclePlasma glycerolAlanine levelsFuel metabolismFluid concentrationsMuscleHyperinsulinemiaMetabolic fuelsHuman subjectsSimilar changesHigh rateTissue
1994
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels
Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. American Journal Of Physiology 1994, 266: e885-e891. PMID: 8023918, DOI: 10.1152/ajpendo.1994.266.6.e885.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusIDDM adolescentsEffect of pubertyGlucose metabolismNondiabetic groupIDDM subjectsInsulin infusionHealthy controlsLeucine fluxHealthy young adult controlsLow-dose insulin infusionPlasma free fatty acid levelsFree fatty acid levelsYoung adult controlsFatty acid levelsAction of insulinLeucine oxidation rateAmino acid/protein metabolismEuglycemic hyperinsulinemiaDiabetes mellitusInsulin resistanceInsulin valuesBasal glucosePlasma insulinNormal pubertyComparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults.
Boulware SD, Tamborlane WV, Rennert NJ, Gesundheit N, Sherwin RS. Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults. Journal Of Clinical Investigation 1994, 93: 1131-1139. PMID: 8132753, PMCID: PMC294058, DOI: 10.1172/jci117065.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factorInsulin-like growth factorHuman insulin-like growth factorMiddle-aged subjectsC-peptideYoung subjectsBasal IGF-I levelsHealthy middle-aged subjectsGlucose uptakeGrowth factorAdverse metabolic changesFree fatty acid levelsIGF-I levelsRelative insulin deficiencyEuglycemic clamp studiesFat oxidation rateDose-response relationshipFatty acid levelsInsulin-induced stimulationMiddle-aged adultsBasal insulinInsulin deficiencyMetabolic effectsClamp studiesRhIGFMetabolic Effects of rhIGF-1 in Normal Human Subjects
Rennert NJ, Boulware SD, Kerr D, Caprio S, Tamborlane WV, Sherwin RS. Metabolic Effects of rhIGF-1 in Normal Human Subjects. Advances In Experimental Medicine And Biology 1994, 343: 311-318. PMID: 8184741, DOI: 10.1007/978-1-4615-2988-0_30.Peer-Reviewed Original ResearchConceptsRhIGF-1Hepatic glucose productionIGF-1Free fatty acidsGlucose productionGlucose uptakeEuglycemic clamp techniqueHuman IGF-1Normal human subjectsSpite of maintenanceSustained euglycemiaMetabolic effectsFFA levelsHypoglycemic effectClamp techniqueMetabolic actionsProfound reductionInsulinHypoglycemic hormoneFat cellsRatsComparable stimulationProtein breakdownSimilar extentEuglycemia
1993
Effect of caffeine on the recognition of and responses to hypoglycemia in humans.
Kerr D, Sherwin RS, Pavalkis F, Fayad PB, Sikorski L, Rife F, Tamborlane WV, During MJ. Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Annals Of Internal Medicine 1993, 119: 799-804. PMID: 8379601, DOI: 10.7326/0003-4819-119-8-199310150-00005.Peer-Reviewed Original ResearchConceptsGlucose levelsHypoglycemic symptomsCaffeine consumptionCounter-regulatory hormone levelsHyperinsulinemic glucose clamp techniqueMiddle cerebral artery velocityLarge carbohydrate loadCerebral artery velocityAcute caffeine ingestionClinical Research CenterLevels of norepinephrineAwareness of hypoglycemiaCerebral blood flowDouble-blind designGlucose clamp techniqueLate postprandial periodPlasma glucose levelsLevels of epinephrineBrain glucose useCaffeine-free colaEffects of caffeineAcute ingestionSympathoadrenal activationArtery velocityPlasma glucoseEffect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin.
Kerr D, Tamborlane WV, Rife F, Sherwin RS. Effect of insulin-like growth factor-1 on the responses to and recognition of hypoglycemia in humans. A comparison with insulin. Journal Of Clinical Investigation 1993, 91: 141-147. PMID: 8423214, PMCID: PMC330007, DOI: 10.1172/jci116163.Peer-Reviewed Original ResearchConceptsRecombinant human insulin-like growth factor-1Insulin-like growth factor-1Growth factor-1Glucagon responseGlucose productionAbsent glucagon responsesPlasma glucose nadirsGrowth hormone responseInsulin-induced hypoglycemiaAwareness of hypoglycemiaGrowth hormone releaseFactor 1Hepatic glucose productionHuman insulin-like growth factor-1Recognition of hypoglycemiaSymptomatic awarenessNorepinephrine levelsCounterregulatory responsesHypoglycemic stimulusSympathetic activityGlucose nadirsGlucagon releaseBlood glucoseRebound increaseHormone release
1992
Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy.
Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Shulman RG, Tamborlane WV. Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 1109-1112. PMID: 1736294, PMCID: PMC48395, DOI: 10.1073/pnas.89.3.1109.Peer-Reviewed Original ResearchDiverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism
Boulware SD, Tamborlane WV, Matthews LS, Sherwin RS. Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism. American Journal Of Physiology 1992, 262: e130-e133. PMID: 1733244, DOI: 10.1152/ajpendo.1992.262.1.e130.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IIGF-I levelsGrowth factor IInsulin secretionTotal IGF-I levelsFree IGF-I levelsAcid metabolismRecombinant human insulin-like growth factor IFactor IAmino acid metabolismFree fatty acid metabolismHealthy nonobese subjectsHuman insulin-like growth factor IHepatic glucose productionBranched-chain amino acidsExogenous glucose infusionFatty acid metabolismGlucagon levelsInsulin levelsNonobese subjectsContinuous infusionConcomitant inhibitory effectTwo- to threefold increaseC-peptideGlucose infusion
1991
Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*
CAPRIO S, BOULWARE S, DIAMOND M, SHERWIN R, CARPENTER TO, RUBIN K, AMIEL S, PRESS M, TAMBORLANE W. Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 832-836. PMID: 2005209, DOI: 10.1210/jcem-72-4-832.Peer-Reviewed Original ResearchConceptsInsulin-stimulated glucose metabolismEarly metabolic defectsNormal controlsGlucose metabolismTurner syndromeEuglycemic clampInsulin resistanceGroup 2Metabolic defectsTurner patientsAge-matched normal controlsChain amino acid levelsGroup of patientsRisk of diabetesNonoxidative glucose disposalIntracellular glucose metabolismWhole-body glucoseHepatic glucose productionNondiabetic patientsEstrogen therapyHormone therapyYounger patientsGlucose disposalHepatic sensitivityInsulin sensitivity