2020
Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes
DuBose SN, Li Z, Sherr JL, Beck RW, Tamborlane WV, Shah VN. Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes. Journal Of Diabetes Science And Technology 2020, 15: 593-599. PMID: 32064911, PMCID: PMC8120054, DOI: 10.1177/1932296820905904.Peer-Reviewed Original ResearchConceptsEffects of exerciseSensor glucose levelsHealthy individualsResistance exerciseNadir glucoseGlucose levelsNonobese body mass indexT1D Exchange Clinic NetworkPeak postprandial glucoseBody mass indexGlucose concentrationTime of mealsNadir glucose concentrationsConsumption of alcoholMass indexPostprandial glucoseNonexercise dayAerobic exerciseExercise dayClinic networkMean changeFuture therapiesDiabetesDexcom G6Glucose monitor data
2016
Mitigating Reductions in Glucose During Exercise on Closed-Loop Insulin Delivery: The Ex-Snacks Study
Patel NS, Van Name MA, Cengiz E, Carria LR, Tichy EM, Weyman K, Weinzimer SA, Tamborlane WV, Sherr JL. Mitigating Reductions in Glucose During Exercise on Closed-Loop Insulin Delivery: The Ex-Snacks Study. Diabetes Technology & Therapeutics 2016, 18: 794-799. PMID: 27996320, PMCID: PMC5178000, DOI: 10.1089/dia.2016.0311.Peer-Reviewed Original ResearchConceptsClosed-loop insulin deliveryPlasma glucoseEnd of exercisePG levelsExercise studiesInsulin deliveryExercise periodCL insulin deliveryExercise-induced loweringType 1 diabetes subjectsExercise-induced reductionRecovery periodBrisk treadmillDL increaseRescue treatmentDiabetes subjectsInsulin infusionExerciseInsulinSimilar differencesVisitsCL controlDeliveryGlucosePeriodEffective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting
Van Name MA, Camp AW, Magenheimer EA, Li F, Dziura JD, Montosa A, Patel A, Tamborlane WV. Effective Translation of an Intensive Lifestyle Intervention for Hispanic Women With Prediabetes in a Community Health Center Setting. Diabetes Care 2016, 39: 525-531. PMID: 26908915, PMCID: PMC4806769, DOI: 10.2337/dc15-1899.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdolescentAdultAgedBody Mass IndexChoice BehaviorCommunity Health CentersDiabetes Mellitus, Type 2ExerciseFeasibility StudiesFemaleFood PreferencesHispanic or LatinoHumansInsulinLife StyleMiddle AgedPilot ProjectsPrediabetic StateRisk FactorsSocioeconomic FactorsWaist CircumferenceWeight LossYoung AdultConceptsIntensive lifestyle interventionDiabetes Prevention ProgramCommunity health center settingUsual care groupType 2 diabetesHealth center settingHispanic womenILI groupLifestyle interventionCare groupOral glucose tolerance testCenter settingLow-income Hispanic womenWeight lossSimilar baseline weightGlucose tolerance testPercent body fatType of interventionCHC settingsDPP interventionsUsual careBaseline weightWaist circumferenceGlucose excursionsTolerance test
2014
Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels
2013
Reduced Hypoglycemia and Increased Time in Target Using Closed-Loop Insulin Delivery During Nights With or Without Antecedent Afternoon Exercise in Type 1 Diabetes
Sherr JL, Cengiz E, Palerm CC, Clark B, Kurtz N, Roy A, Carria L, Cantwell M, Tamborlane WV, Weinzimer SA. Reduced Hypoglycemia and Increased Time in Target Using Closed-Loop Insulin Delivery During Nights With or Without Antecedent Afternoon Exercise in Type 1 Diabetes. Diabetes Care 2013, 36: 2909-2914. PMID: 23757427, PMCID: PMC3781513, DOI: 10.2337/dc13-0010.Peer-Reviewed Original ResearchConceptsNocturnal hypoglycemiaType 1 diabetesAfternoon exerciseInsulin deliveryAntecedent exerciseTarget blood glucose rangeCL insulin deliveryClosed-loop insulin deliveryLoop insulin deliveryTarget rangeBlood glucose levelsBlood glucose rangeMaximum heart rateCL controlBrisk treadmillReduced hypoglycemiaSedentary dayExercise dayPercentage of timeGlucose levelsHeart rateGlucose valuesType 1Random orderStudy period
2007
Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial
Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S. Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial. JAMA 2007, 297: 2697-2704. PMID: 17595270, DOI: 10.1001/jama.297.24.2697.Peer-Reviewed Original ResearchConceptsWeight management programWeight management groupOverweight childrenMetabolic complicationsInsulin resistanceBody fatBody compositionControl groupArray of comorbiditiesMost overweight childrenSix-month improvementsHomeostasis model assessmentPediatric obesity clinicSerious metabolic complicationWeight management counselingType 2 diabetesMajor health issueFamily-based programsMixed ethnic groupsMonths of studyHOMA-IRObesity clinicOverweight adultsControlled TrialsPediatric obesityTriple Jeopardy: Nocturnal Hypoglycemia after Exercise in the Young with Diabetes
Tamborlane WV. Triple Jeopardy: Nocturnal Hypoglycemia after Exercise in the Young with Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 815-816. PMID: 17341578, DOI: 10.1210/jc.2007-0016.Peer-Reviewed Original Research
2005
Impact of Exercise on Overnight Glycemic Control in Children with Type 1 Diabetes Mellitus
Tsalikian E, Mauras N, Beck RW, Tamborlane WV, Janz KF, Chase HP, Wysocki T, Weinzimer SA, Buckingham BA, Kollman C, Xing D, Ruedy KJ. Impact of Exercise on Overnight Glycemic Control in Children with Type 1 Diabetes Mellitus. The Journal Of Pediatrics 2005, 147: 528-534. PMID: 16227041, PMCID: PMC2258153, DOI: 10.1016/j.jpeds.2005.04.065.Peer-Reviewed Original ResearchConceptsGlucose levelsExercise nightsOvernight hypoglycemiaType 1 diabetes mellitusOvernight glycemic controlClinical Research CenterRisk of hypoglycemiaEffects of exerciseImpact of exerciseBlood glucose levelsAfternoon exerciseDiabetes mellitusGlycemic controlInsulin dosesSedentary dayExercise dayExercise sessionsDiabetes managementHypoglycemiaSeparate daysClinical sitesType 1Central laboratoryMellitusT1DMAccuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study.
Weinzimer SA, Beck RW, Chase HP, Fox LA, Buckingham BA, Tamborlane WV, Kollman C, Coffey J, Xing D, Ruedy KJ. Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study. Diabetes Technology & Therapeutics 2005, 7: 675-80; discussion 681-3. PMID: 16241867, PMCID: PMC1351386, DOI: 10.1089/dia.2005.7.675.Peer-Reviewed Original ResearchConceptsHome glucose metersStandardized exercise protocolVenous blood samplesEffects of exerciseType 1 diabetesGlucose metersExercise protocolNocturnal hypoglycemiaExercise studiesVenous bloodGlucose levelsBlood samplesDetection of hypoglycemiaBlood glucose metersClinical settingHome blood glucose metersDiabetes researchCentral laboratoryHexokinase enzymatic methodGlucose measurementsGlucose concentration
2003
Insulin Pump Therapy in Childhood Diabetes Mellitus
Tamborlane WV, Fredrickson LP, Ahern JH. Insulin Pump Therapy in Childhood Diabetes Mellitus. Treatments In Endocrinology 2003, 2: 11-21. PMID: 15871551, DOI: 10.2165/00024677-200302010-00002.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionSevere hypoglycemiaEffectiveness of CSIIType 1 diabetes mellitusRapid-acting insulin analoguesDevelopment of ketoacidosisNear-normal glycemiaOvernight glycemic controlProgrammable basal ratesExcessive weight gainSelection of patientsExercise-induced hypoglycemiaInitiation of treatmentInsulin pump therapySubcutaneous insulin infusionBlood glucose levelsTiming of mealsQuality of lifeContinuous glucose monitoringCare of childrenBolus capabilitiesPediatrie patientsDiabetic ketoacidosisVascular complicationsDiabetes mellitus