1995
Central adiposity and its metabolic correlates in obese adolescent girls
Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, Shulman G, Tamborlane WV. Central adiposity and its metabolic correlates in obese adolescent girls. American Journal Of Physiology 1995, 269: e118-e126. PMID: 7631766, DOI: 10.1152/ajpendo.1995.269.1.e118.Peer-Reviewed Original ResearchConceptsObese adolescent girlsObese girlsInsulin secretionInsulin actionSubcutaneous abdominal fat depotsFree fatty acid levelsGlucose-stimulated insulin responseHip circumference ratioEuglycemic insulin clampHyperglycemic clamp techniqueBasal insulin secretionAbdominal fat depotsAdolescent girlsHepatic glucose productionFatty acid levelsMagnetic resonance imagingLean womenCentral adiposityInsulin dosesVisceral fatInsulin clampInsulin resistanceNonobese girlsGlucose disposalInsulin infusion
1991
Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*
AMIEL S, CAPRIO S, SHERWIN R, PLEWE G, HAYMOND M, TAMBORLANE W. Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 277-282. PMID: 1991798, DOI: 10.1210/jcem-72-2-277.Peer-Reviewed Original ResearchConceptsPeripheral glucose metabolismInsulin resistancePubertal childrenGlucose metabolismHigher insulin doseMU/m2Hyperglycemic clamp studiesEuglycemic insulin clampEnhanced insulin responseHepatic glucose productionSelective insulin resistanceChain amino acidsHealthy prepubertalCompensatory hyperinsulinemiaInsulin doseInsulin clampPeripheral glucoseInsulin responsePlasma levelsPrepubertal childrenClamp studiesProtein anabolismNormal pubertyGlucose productionAmino acid metabolism