2001
Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting
Mesri M, Morales-Ruiz M, Ackermann E, Bennett C, Pober J, Sessa W, Altieri D. Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting. American Journal Of Pathology 2001, 158: 1757-1765. PMID: 11337373, PMCID: PMC1891951, DOI: 10.1016/s0002-9440(10)64131-4.Peer-Reviewed Original ResearchApoptosisCell MovementCells, CulturedDNADNA, AntisenseDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularGene Expression RegulationHumansInhibitor of Apoptosis ProteinsLymphokinesMicrotubule-Associated ProteinsNeoplasm ProteinsProteinsRNA, MessengerSurvivinVascular Endothelial Growth Factor AVascular Endothelial Growth Factors
2000
Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway*
Papapetropoulos A, Fulton D, Mahboubi K, Kalb R, O'Connor D, Li F, Altieri D, Sessa W. Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway*. Journal Of Biological Chemistry 2000, 275: 9102-9105. PMID: 10734041, DOI: 10.1074/jbc.275.13.9102.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietin-1AnimalsApoptosisCattleCells, CulturedEndothelium, VascularFlow CytometryInhibitor of Apoptosis ProteinsMembrane GlycoproteinsMicrotubule-Associated ProteinsNeoplasm ProteinsPhosphorylationProtein Serine-Threonine KinasesProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-aktSurvivinConceptsAkt/survivin pathwaySerine-threonine kinaseDeath-inducing stimuliPost-natal angiogenesisDominant-negative survivinEndothelial cellsEndothelial cell survivalAnti-apoptotic pathwaysSurvival machineryEndothelial cell apoptosisSurvivin pathwayApoptosis inhibitorCell survivalCell apoptosisVascular stabilizationAktSurvivinTie-2 receptorAngiogenic responseApoptosisCellsPathwayAngiogenesisMorphogenesisKinase
1998
Biological Action of Leptin as an Angiogenic Factor
Sierra-Honigmann M, Nath A, Murakami C, Garcı́a-Cardeña G, Papapetropoulos A, Sessa W, Madge L, Schechner J, Schwabb M, Polverini P, Flores-Riveros J. Biological Action of Leptin as an Angiogenic Factor. Science 1998, 281: 1683-1686. PMID: 9733517, DOI: 10.1126/science.281.5383.1683.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAmino Acid SequenceAnimalsCarrier ProteinsCells, CulturedCorneal NeovascularizationDNA-Binding ProteinsEndothelial Growth FactorsEndothelium, VascularEnergy MetabolismHumansLeptinLipid MetabolismLymphokinesMolecular Sequence DataNeovascularization, PhysiologicPhosphorylationProteinsRatsRats, ZuckerReceptors, Cell SurfaceReceptors, LeptinSTAT3 Transcription FactorTrans-ActivatorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsFa/fa Zucker ratFunctional leptin receptorHuman endothelial cellsNormal ratsFood intakeLeptin receptorVascular endotheliumZucker ratsLeptinOb-RbAngiogenic factorsEndothelial cellsAngiogenic activityPrimary culturesEnergy expenditureBiological actionsHuman vasculatureVivo assaysRatsCorneaReceptorsPhysiological mechanisms