Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α
Li G, Wang A, Tang W, Fu W, Tian Q, Jian J, Lata M, Hettinghouse A, Ding Y, Wei J, Zhao X, Wang M, Dong Q, Liu C, Xu Y. Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α. Genes & Diseases 2024, 12: 101221. PMID: 39559258, PMCID: PMC11570241, DOI: 10.1016/j.gendis.2024.101221.Peer-Reviewed Original ResearchPostmenopausal osteoporosisEstrogen receptorReceptor AEstrogen signalingTreatment of postmenopausal osteoporosisOvariectomy-induced bone lossEstrogen-mediated inhibitionRegulation of bone mineral densityBone mineral densityEstrogen receptor aPGRN-deficient miceInhibition of osteoclastogenesisPostmenopausal womenEstrogen deficiencyMineral densityLoss of progranulinEstrogen regulationBone lossBone massPositive feedback regulatory loopBone resorptionOsteoporosisTherapeutic approachesEstrogenOsteoporosis model