THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis
Fu W, Hettinghouse A, Liu C. THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis. Annals Of The Rheumatic Diseases 2018, 77: 252. DOI: 10.1136/annrheumdis-2018-eular.4729.Peer-Reviewed Original ResearchAnti-inflammatory actionTNF receptor 2Mean fluorescence intensityAnti-inflammation actionClinical arthritis scoreInflammatory arthritisCIA miceAnti-inflammatory effectsAnti-inflammatory activityMacrophage polarizationProtective effectArthritis scoreCritical downstream mediatorM2 polarizationΔ miceM1-M2 polarizationPresence of progranulinAnti-inflammatory pathwaySeverity of CIADownstream mediatorSignificant decreasePercentage of CD206Hallmarks of macrophagesPGRN effectsWT miceOP0224 Adamts-12 protects against inflammatory arthritis through interacting with proinflammatory ctgf
Fu W, Wei J, Hettinghouse A, He W, Liu C. OP0224 Adamts-12 protects against inflammatory arthritis through interacting with proinflammatory ctgf. Annals Of The Rheumatic Diseases 2018, 77: 160. DOI: 10.1136/annrheumdis-2018-eular.4748.Peer-Reviewed Original ResearchCollagen-induced arthritisClinical arthritis scoreInflammatory arthritisADAMTS-12Arthritis scoreCTGF antibodyIL-1βDisease onsetHistological analysisAccelerated disease onsetCIA mouse modelAnti-inflammatory cytokinesRheumatoid arthritis developmentPro-inflammatory roleFurther tissue destructionDestruction of boneSignificant increaseCritical regulatorCIA miceRA patientsArthritis developmentArthritis incidenceKO miceNormal inflammationSafranin O staining