2019
Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis
Liu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei Z, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen Z, Liu C. Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. Annals Of The Rheumatic Diseases 2019, 78: 1524. PMID: 31302596, PMCID: PMC8157820, DOI: 10.1136/annrheumdis-2019-215543.Peer-Reviewed Original ResearchConceptsAnti-TNF activityCytosolic phospholipase A2Inflammatory arthritisTNF-α transgenic miceInflammatory arthritis modelInflammatory rheumatic diseasesCollagen-induced arthritisAnti-inflammatory activityPhospholipase A2New therapeutic interventionsActivated B cellsTNF-α signalingNecrosis factor-alpha signalingDrug affinity responsive target stabilityDBA/1 miceRheumatic diseasesArthritis modelAutoimmune diseasesCellular thermal shiftSerial screeningB cellsTransgenic miceArthritisDrug AdministrationTherapeutic interventions
2018
THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis
Fu W, Hettinghouse A, Liu C. THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis. Annals Of The Rheumatic Diseases 2018, 77: 252. DOI: 10.1136/annrheumdis-2018-eular.4729.Peer-Reviewed Original ResearchAnti-inflammatory actionTNF receptor 2Mean fluorescence intensityAnti-inflammation actionClinical arthritis scoreInflammatory arthritisCIA miceAnti-inflammatory effectsAnti-inflammatory activityMacrophage polarizationProtective effectArthritis scoreCritical downstream mediatorM2 polarizationΔ miceM1-M2 polarizationPresence of progranulinAnti-inflammatory pathwaySeverity of CIADownstream mediatorSignificant decreasePercentage of CD206Hallmarks of macrophagesPGRN effectsWT mice