2024
Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls
Díaz D, Tseng W, Michalska K. Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls. BMC Psychiatry 2024, 24: 1. PMID: 38167015, PMCID: PMC10759434, DOI: 10.1186/s12888-023-05403-6.Peer-Reviewed Original ResearchConceptsState anxietyTrait anxietyHappy facesEmotion processingLatina girlsImplicit emotion processingNon-anxious youthHigh trait anxietyFearful facial affectFearful facesEmotional valenceFacial affectNeural correlatesIndividual differencesBrain activationBrain responsesNeural activationReduced engagementCommunity sampleAnxietyInteractive effectsHigh levelsGirlsMethodsThe present studySystematic differences
2023
Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol
Grasser L, Erjo T, Goodwin M, Naim R, German R, White J, Cullins L, Tseng W, Stoddard J, Brotman M. Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol. BMC Psychiatry 2023, 23: 926. PMID: 38082431, PMCID: PMC10712194, DOI: 10.1186/s12888-023-05421-4.Peer-Reviewed Original ResearchConceptsExposure-based cognitive-behavioral therapyCognitive behavioral therapyPhysiological arousalBehavioral therapyAffective Reactivity IndexMultiple baseline trialClinical Global Impression ScaleAnger-inducing stimuliPeripheral physiological indicatorsIndividual differencesPsychophysiological markersPerson changesExposure sessionsMultilevel modelingPsychophysiological indicatorsHR/HRVInitial evidenceMental healthReasons youthReactivity indexYouthAppropriate Institutional Review BoardTreatment mechanismsGlobal Impression ScaleCourse of treatmentNetwork analysis of ecological momentary assessment identifies frustration as a central node in irritability
Tseng W, Naim R, Chue A, Shaughnessy S, Meigs J, Pine D, Leibenluft E, Kircanski K, Brotman M. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability. Journal Of Child Psychology And Psychiatry 2023, 64: 1212-1221. PMID: 36977629, PMCID: PMC10615387, DOI: 10.1111/jcpp.13794.Peer-Reviewed Original Research
2022
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Linke J, Haller S, Xu E, Nguyen L, Chue A, Botz-Zapp C, Revzina O, Perlstein S, Ross A, Tseng W, Shaw P, Brotman M, Pine D, Gotts S, Leibenluft E, Kircanski K. Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 684-695. PMID: 36563874, PMCID: PMC11224120, DOI: 10.1016/j.jaac.2022.11.009.Peer-Reviewed Original ResearchConceptsResting-state scansPathophysiology of irritabilitySelf-reported irritabilityFunctional magnetic resonance imagingMagnetic resonance imagingParent-reported irritabilitySpecific intervention targetsRisk factorsMotor functionPsychiatric consultationCircuit reorganizationCommon reasonAffective disordersBrain network configurationIrritability symptomsResonance imagingBrain regionsIrritabilityCentral mechanismsAberrant responsesPilot studyIntervention targetsRecovery periodPediatric irritabilityBrain networksAtypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interactionDifferences in white matter segments in autistic males, non-autistic siblings, and non-autistic participants: An intermediate phenotype approach
Chien YL, Chen YJ, Tseng WL, Hsu YC, Wu CS, Tseng WI, Gau SS. Differences in white matter segments in autistic males, non-autistic siblings, and non-autistic participants: An intermediate phenotype approach. Autism 2022, 27: 1036-1052. PMID: 36254873, DOI: 10.1177/13623613221125620.Peer-Reviewed Original ResearchConceptsNon-autistic siblingsNon-autistic peopleAutistic peopleAutistic traitsBrain regionsTheory of mindNon-autistic participantsHigher cognitive functionsAnterior brain regionsSocial cognitionNeurocognitive strengthsNeuropsychological characteristicsCognitive functionAutistic malesDifferent brain regionsAutismBrain adaptationIntermediate phenotype approachWhite matter differencesFuture researchNeural pathwaysBiological basisPeopleSiblingsCausal linkSystematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability
Lee KS, Hagan CN, Hughes M, Cotter G, Freud E, Kircanski K, Leibenluft E, Brotman MA, Tseng WL. Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 208-229. PMID: 35944754, PMCID: PMC9892288, DOI: 10.1016/j.jaac.2022.05.014.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFMRI studyNeurocognitive functionNeural convergenceActivation likelihood estimationLow frustration toleranceIrritability measuresFrequent temper tantrumsSample characteristicsCognitive controlFMRI taskEmotional reactivityStimulus typeFMRI resultsChildhood irritabilityFrustration toleranceNeural mechanismsFunctional neuroimagingTransdiagnostic symptomsTask domainTemper tantrumsFMRI methodsNeuroscience databasesNull findingsCoordinate-based data
2021
Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study
Lee KS, Xiao J, Liew Z, Gau SS, Tseng WL. Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study. Journal Of Affective Disorders 2021, 299: 273-280. PMID: 34906640, PMCID: PMC8767526, DOI: 10.1016/j.jad.2021.12.016.Peer-Reviewed Original ResearchConceptsNational epidemiological studyBirth characteristicsEpidemiological studiesChildhood irritabilityEarly life exposureAdverse mental healthBirth correlatesPerinatal perspectiveVaginal bleedingMaternal smokingAffective Reactivity IndexPerinatal risksBirth factorsLife exposureProspective assessmentIrritabilityTemper outburstsRecall biasLife outcomesPerinatalMental healthEarly etiologyChild irritabilityRetrospective assessmentEnvironmental exposuresNeural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability
Tseng WL, Abend R, Gold AL, Brotman MA. Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability. Journal Of Affective Disorders 2021, 295: 920-929. PMID: 34706463, PMCID: PMC8554134, DOI: 10.1016/j.jad.2021.08.117.Peer-Reviewed Original ResearchConceptsHigh negative affectivityNegative affectivityThreat appraisalPediatric anxietyAnxiety disordersThreat-safety discriminationWhole-brain activationLinear mixed effects analysisNegative affectivity factorExtinction recallThreat conditioningThreat contingenciesElevated irritabilityNeural correlatesTransdiagnostic sampleGreater prefrontalOccipital activationUnique varianceExplicit recallThreat responsesFMRI paradigmNeural mechanismsTask conditionsAmygdala connectivityMixed effects analysisThe Prefrontal Cortex in a Pandemic: Restoring Functions With System-, Family-, and Individual-Focused Interventions
Arnsten AFT, Condon EM, Dettmer AM, Gee DG, Lee KS, Mayes LC, Stover CS, Tseng WL. The Prefrontal Cortex in a Pandemic: Restoring Functions With System-, Family-, and Individual-Focused Interventions. American Psychologist 2021, 76: 729-743. PMID: 33983754, PMCID: PMC8589866, DOI: 10.1037/amp0000823.BooksConceptsStress-related mental health problemsMental health problemsSensitive parentingParent-child functioningPrefrontal cortical functionMental health risksPrefrontal cortexCOVID-19 pandemicChronic stressorsMental healthVital avenueCortical functionBehavioral mechanismsBehavioral healthParentingHealth problemsChronic stressChildrenClinical evidenceNeuroscienceInterventionFunctioningStressorsCOVID-19CortexRates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population
Xia Y, Xiao J, Yu Y, Tseng WL, Lebowitz E, DeWan AT, Pedersen LH, Olsen J, Li J, Liew Z. Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population. JAMA Network Open 2021, 4: e2114913. PMID: 34185070, PMCID: PMC8243234, DOI: 10.1001/jamanetworkopen.2021.14913.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLate pretermNeuropsychiatric disordersMajor neuropsychiatric disordersEarly termTerm birthsGestational agePostterm birthSingleton birthsAdult-onset neuropsychiatric disordersDanish Medical Birth RegisterLower incidence rate ratiosGestational age subgroupsMedical Birth RegisterGestational age groupsHigh ratePostterm groupGestational durationCohort studyNationwide registersPerinatal factorsPreterm birthBirth RegisterVery pretermAge subgroupsFunctional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2020
Psychiatric comorbidity and social adjustment difficulties in children with disruptive mood dysregulation disorder: A national epidemiological study
Lin YJ, Tseng WL, Gau SS. Psychiatric comorbidity and social adjustment difficulties in children with disruptive mood dysregulation disorder: A national epidemiological study. Journal Of Affective Disorders 2020, 281: 485-492. PMID: 33383391, PMCID: PMC8142276, DOI: 10.1016/j.jad.2020.12.039.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderOppositional defiant disorderSocial adjustment difficultiesAdjustment difficultiesPsychiatric comorbiditySocial Adjustment InventoryKiddie epidemiologic versionParent-child interactionsChildhood mental disordersAdjustment InventoryDefiant disorderEpidemiologic VersionParental educational levelAcademic performanceMore difficultyDSM-5More problemsHigh psychiatric comorbiditySchool functionTaiwanese childrenMental disordersNational epidemiological studyChildrenAffective disordersSevere impairmentBehavioral Problems at Age 11 Years After Prenatal and Postnatal Exposure to Acetaminophen: Parent-Reported and Self-Reported Outcomes
Inoue K, Ritz B, Ernst A, Tseng WL, Yuan Y, Meng Q, Ramlau-Hansen CH, Strandberg-Larsen K, Arah OA, Obel C, Li J, Olsen J, Liew Z. Behavioral Problems at Age 11 Years After Prenatal and Postnatal Exposure to Acetaminophen: Parent-Reported and Self-Reported Outcomes. American Journal Of Epidemiology 2020, 190: 1009-1020. PMID: 33230558, PMCID: PMC8248972, DOI: 10.1093/aje/kwaa257.Peer-Reviewed Original ResearchConceptsPrenatal acetaminophen exposurePostnatal exposureAcetaminophen exposureAge 11 yearsHigh riskDanish National Birth CohortBehavioral problemsNational Birth CohortTotal difficultiesChild-reported scoresMother-child pairsAcetaminophen usePrenatal exposureRisk ratioBirth cohortSDQ scoresCumulative weeksYoung childrenAssociationExposurePrenatalChildrenBehavioral outcomesOutcomesEarly adolescenceEditorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorderA preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder
Ross AJ, Roule AL, Deveney CM, Towbin KE, Brotman MA, Leibenluft E, Tseng W. A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder. Bipolar Disorders 2020, 23: 263-273. PMID: 32790927, PMCID: PMC8074834, DOI: 10.1111/bdi.12985.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusFeedback processingBD youthNeural responsesReward-relevant stimuliFunctional activationSelf-reported frustrationSelf-reported affectAtypical activation patternsGoal-directed behaviorPrefrontal cortex connectivityBipolar disorderBipolar disorder youthAttentional abilitiesAttention taskImpaired attentionFMRI paradigmTask performanceFrontal gyrusAttention networkGreater recruitmentCortex connectivityGreater unhappinessIrritability symptomsInterest activationDevelopmental Course and Risk Factors of Physical Aggression in Late Adolescence
Henriksen M, Skrove M, Hoftun GB, Sund ER, Lydersen S, Tseng WL, Sukhodolsky DG. Developmental Course and Risk Factors of Physical Aggression in Late Adolescence. Child Psychiatry & Human Development 2020, 52: 628-639. PMID: 32852728, PMCID: PMC8238740, DOI: 10.1007/s10578-020-01049-7.Peer-Reviewed Original ResearchConceptsRisk factorsMale genderAggressive behaviorLate adolescenceHeavy drinkingEarly adolescenceStudy sampleLongitudinal studyPhysical aggressionAdolescencePhysical aggressive behaviorAdolescentsNorwegian adolescentsPhysical fightsAttention problemsYoung adolescentsDrinkingDevelopmental courseGenderSmokingFactorsStudyPrenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasmaExecutive functions in youths with autism spectrum disorder and their unaffected siblings
Seng GJ, Tseng WL, Chiu YN, Tsai WC, Wu YY, Gau SS. Executive functions in youths with autism spectrum disorder and their unaffected siblings. Psychological Medicine 2020, 51: 2571-2580. PMID: 32349803, DOI: 10.1017/s0033291720001075.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpatial working memoryExecutive function tasksExecutive functionASD youthWorking memoryFunction tasksCognitive endophenotypesSpatial spanExecutive dysfunctionSpectrum disorderUnaffected siblingsCambridge Neuropsychological Test Automated BatteryAttention-deficit/hyperactivity disorderPotential cognitive endophenotypesExtra-dimensional shiftPlanning/problemVisuospatial working memoryBackward digit recallMain cognitive theoriesStockings of CambridgeDigit span testEvidence of deficitsCognitive theoryDigit recallFixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior
Grazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG. Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 5: 490-498. PMID: 32144044, PMCID: PMC7214205, DOI: 10.1016/j.bpsc.2019.12.018.Peer-Reviewed Original ResearchConceptsWhite matter densityCorpus callosumFiber densityAggressive behaviorCingulum bundleAbnormal interhemispheric connectivityHealthy control childrenWhite matter abnormalitiesAttention-deficit/hyperactivity disorderMiddle cerebellar peduncleSuperior thalamic radiationMagnetic resonance imagingInferior fronto-occipital fasciculusWhole-brain analysisInferior longitudinal fasciculusFronto-occipital fasciculusPotential neural mechanismsWhite matter microstructureDiffusion magnetic resonance imagingInterhemispheric connectivityCortical pathwaysCerebellar peduncleChild Behavior ChecklistThalamic radiationFiber bundle density