Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled TrialsOptimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis
LeVasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy AA, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. Optimising weight-loss interventions in cancer patients—A systematic review and network meta-analysis. PLOS ONE 2021, 16: e0245794. PMID: 33539414, PMCID: PMC7861370, DOI: 10.1371/journal.pone.0245794.Peer-Reviewed Original ResearchConceptsBody mass indexStandard careCancer patientsDietary interventionAnthropometric measuresLifestyle interventionWaist circumferenceWeight lossSystematic reviewCochrane Trial RegistryEffective lifestyle interventionsGreater BMI reductionMedian intervention durationOptimal lifestyle interventionCombination strategiesAdult cancer patientsWeight loss interventionEffects of exerciseEarly-stage cancerOutcomes of interestMore weight lossBMI reductionAdult patientsExercise interventionTrials Registry