Featured Publications
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Medicine 2021, 47: 943-960. PMID: 34379152, PMCID: PMC8356549, DOI: 10.1007/s00134-021-06490-3.Peer-Reviewed Original ResearchConceptsNon-pharmacological interventionsDelirium occurrenceIll adultsIll patientsInternational Clinical Trials RegistryDuration of deliriumOccurrence of deliriumMechanical ventilation durationMulti-component non-pharmacological interventionsClinical Trials RegistryLength of stayMulti-component interventionRandom-effects modelingEvidence networksWeb of ScienceEvidence certaintySedation interruptionSedative interruptionHospital lengthICU lengthCochrane riskSecondary outcomesStandard careBias toolControlled Trials
2019
Pharmacological interventions for the treatment of delirium in critically ill adults
Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. 2019, 9: cd011749. PMID: 31479532, PMCID: PMC6719921, DOI: 10.1002/14651858.cd011749.pub2.Peer-Reviewed Original ResearchConceptsTreatment of deliriumIntensive care unitComa-free daysDuration of deliriumNon-pharmacological interventionsLong-term outcomesIll adultsPharmacological interventionsMechanical ventilationAgonist dexmedetomidineDrug classesICU stayIll patientsReview authorsPatient outcomesOvid MEDLINELonger intensive care unitLong-term cognitive outcomesActive drug treatmentAvailable pharmacological interventionsMultiple pharmacological interventionsLonger ICU stayIll adult patientsResolution of symptomsHigh dependency unit