2004
The role of actin in the regulation of dendritic spine morphology and bidirectional synaptic plasticity
Chen Y, Bourne J, Pieribone VA, Fitzsimonds RM. The role of actin in the regulation of dendritic spine morphology and bidirectional synaptic plasticity. Neuroreport 2004, 15: 829-832. PMID: 15073524, DOI: 10.1097/00001756-200404090-00018.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBridged Bicyclo Compounds, HeterocyclicCytochalasin DDendritesElectric StimulationExcitatory Postsynaptic PotentialsHippocampusIn Vitro TechniquesMaleMicroscopy, ElectronNeuronal PlasticityNeuronsNucleic Acid Synthesis InhibitorsRatsRats, Sprague-DawleySynapsesThiazolesThiazolidinesConceptsExcitatory synaptic transmissionDendritic spine morphologySynaptic transmissionSpine morphologyRat hippocampal slicesHigh-frequency stimulationLong-term depressionBidirectional synaptic plasticityHippocampal slicesIrreversible depressionExcitatory synapsesDendritic spinesMammalian CNSSynaptic efficacySynaptic plasticityDepressionSpineCNSPotentiationSynapses
1999
Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function
Low P, Norlin T, Risinger C, Larhammar D, Pieribone V, Shupliakov O, Brodin L. Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function. European Journal Of Cell Biology 1999, 78: 787-793. PMID: 10604655, DOI: 10.1016/s0171-9335(99)80029-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAxonsCell MembraneImmunohistochemistryIn Situ HybridizationLampreysMembrane ProteinsMicroinjectionsMicroscopy, ElectronNerve Tissue ProteinsNeurotransmitter AgentsProtein BindingRecombinant Fusion ProteinsSpinal CordSynapsesSynaptic TransmissionSynaptic VesiclesSynaptosomal-Associated Protein 25ConceptsPlasma membraneSynaptic vesiclesSNAP-25Lamprey giant reticulospinal synapsePresynaptic plasma membraneSynaptic vesicle exocytosisLamprey reticulospinal synapseSNARE protein SNAP-25Protein SNAP-25Synaptic vesicle clustersNeurotransmitter releaseSNARE complexMolecular machineryVesicle exocytosisMembrane fusionVesicle cyclingPresynaptic microinjectionVesicle clustersSyntaxinPresynaptic membraneVesiclesElectron microscopic analysisAntibody-mediated disruptionMembraneMicroscopic analysisSynapsins as regulators of neurotransmitter release
Hilfiker S, Pieribone V, Czernik A, Kao H, Augustine G, Greengard P. Synapsins as regulators of neurotransmitter release. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 269-279. PMID: 10212475, PMCID: PMC1692497, DOI: 10.1098/rstb.1999.0378.Peer-Reviewed Original ResearchConceptsSynapsin functionSynaptic vesiclesSynaptic vesicle life cycleReserve poolNeuron-specific phosphoproteinNeurotransmitter releaseSelective disruptionVesicle dockingMultigene familyNumerous proteinsCytoskeletal meshworkAbundant proteinsCytoskeletal proteinsMolecular mechanismsProtein componentsSynapsinSynapse formationPresynaptic nerve terminalsVesiclesProteinSecond roleRelease of neurotransmittersLife cycleCurrent understandingSquid giant synapse
1994
A functional role for nitric oxide in locus coeruleus: immunohistochemical and electrophysiological studies
Xu Z, Pieribone V, Zhang X, Grillner S, Hökfelt T. A functional role for nitric oxide in locus coeruleus: immunohistochemical and electrophysiological studies. Experimental Brain Research 1994, 98: 75-83. PMID: 7516892, DOI: 10.1007/bf00229111.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAmino Acid OxidoreductasesAnimalsArginineElectric StimulationElectrophysiologyEvoked PotentialsHemoglobinsImmunohistochemistryIn Vitro TechniquesLocus CoeruleusMaleMicroscopy, ElectronNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOmega-N-MethylarginineQuinoxalinesRatsRats, Sprague-DawleySynapsesSynaptic TransmissionTyrosine 3-MonooxygenaseConceptsNeuronal nitric oxideExcitatory postsynaptic potentialsLocus coeruleusNitric oxideFocal electrical stimulationNitric oxide synthaseArginine methyl esterNeuronal cell bodiesRat locus coeruleusNOS inhibitor nitroLC neuronsNG-monomethylLike immunoreactivityNOS inhibitorPostsynaptic potentialsBath applicationOxide synthaseIntracellular recordingsSynaptic transmissionBrain slicesImmunohistochemical analysisElectrophysiological studiesElectrical stimulationAxonal processesCell bodies