Featured Publications
High-speed low-light in vivo two-photon voltage imaging of large neuronal populations
Platisa J, Ye X, Ahrens A, Liu C, Chen I, Davison I, Tian L, Pieribone V, Chen J. High-speed low-light in vivo two-photon voltage imaging of large neuronal populations. Nature Methods 2023, 20: 1095-1103. PMID: 36973547, PMCID: PMC10894646, DOI: 10.1038/s41592-023-01820-3.Peer-Reviewed Original ResearchConceptsNeuronal populationsLarge neuronal populationsNeural circuit functionTwo-photon voltage imagingAwake behaving miceCalcium imagingBehaving miceVoltage imagingCircuit functionNeuronsShot noise levelShot-noise limitImagingTwo-photon microscopeKilohertz frame ratesDeep-tissue imagingPopulationVoltage indicatorsField of viewMiceShot noise
2007
In Vivo Simultaneous Tracing and Ca2+ Imaging of Local Neuronal Circuits
Nagayama S, Zeng S, Xiong W, Fletcher ML, Masurkar AV, Davis DJ, Pieribone VA, Chen WR. In Vivo Simultaneous Tracing and Ca2+ Imaging of Local Neuronal Circuits. Neuron 2007, 53: 789-803. PMID: 17359915, PMCID: PMC1892750, DOI: 10.1016/j.neuron.2007.02.018.Peer-Reviewed Original ResearchConceptsLocal neuronal circuitsNeuronal circuitsAxon boutonsPostsynaptic dendritesDifferent glomeruliDendritic spinesNeuronal circuitryPresynaptic boutonsPurkinje cellsSuch activity patternsEnsemble activityLocal electroporationSpecific connectivityBoutonsSimultaneous tracingParallel fibersNeuronsImagingVivoActivity patternsPopulation levelLarge populationGlomeruliBrainSpine
2006
Actin polymerization regulates clathrin coat maturation during early stages of synaptic vesicle recycling at lamprey synapses
Bourne J, Morgan JR, Pieribone VA. Actin polymerization regulates clathrin coat maturation during early stages of synaptic vesicle recycling at lamprey synapses. The Journal Of Comparative Neurology 2006, 497: 600-609. PMID: 16739194, DOI: 10.1002/cne.21006.Peer-Reviewed Original Research
1995
Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice
Pieribone VA, Xu Z, Zhang X, Grillner S, Bartfai T, Hökfelt T. Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience 1995, 64: 861-874. PMID: 7538638, DOI: 10.1016/0306-4522(94)00450-j.Peer-Reviewed Original ResearchConceptsLocus coeruleus neuronsCoeruleus neuronsLocus coeruleusNet outward currentGalanin responseOutward currentsATP-sensitive potassium channelsNorepinephrine-containing locus coeruleus neuronsCoexistence of galaninEffects of galaninPotassium concentrationExtracellular potassium concentrationEndogenous galaninGalanin applicationNormal potassium concentrationGalanin effectsGalanin immunoreactivityBrainstem slicesNorepinephrine neuronsAxonal originLow calcium mediumNeuronal somataSlice preparationImmunohistochemical stainingGalanin