2004
A role for talin in presynaptic function
Morgan JR, Di Paolo G, Werner H, Shchedrina VA, Pypaert M, Pieribone VA, De Camilli P. A role for talin in presynaptic function. Journal Of Cell Biology 2004, 167: 43-50. PMID: 15479735, PMCID: PMC2172527, DOI: 10.1083/jcb.200406020.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBlotting, WesternCell AdhesionClathrinEndocytosisGlutathione TransferaseHumansLampreysLipid MetabolismMicroscopy, ConfocalMicroscopy, Electron, TransmissionPeptidesPhosphotransferases (Alcohol Group Acceptor)Protein BindingProtein Structure, TertiaryRatsSynapsesTalinTime FactorsConceptsSynaptic vesicle endocytosisClathrin-mediated synaptic vesicle endocytosisClathrin-coated pitsEndocytic defectsMajor phosphatidylinositolActin cytoskeletonVesicle endocytosisActin dynamicsKinase interactionTalinPIP kinasePresynaptic compartmentFunctional linkCell adhesionNeuronal synapsesEndocytosisSynaptic rolePresynaptic functionSynaptic actinActinPhosphatidylinositolSynaptic structureIgammaClathrinCytoskeleton
1999
Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function
Low P, Norlin T, Risinger C, Larhammar D, Pieribone V, Shupliakov O, Brodin L. Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function. European Journal Of Cell Biology 1999, 78: 787-793. PMID: 10604655, DOI: 10.1016/s0171-9335(99)80029-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAxonsCell MembraneImmunohistochemistryIn Situ HybridizationLampreysMembrane ProteinsMicroinjectionsMicroscopy, ElectronNerve Tissue ProteinsNeurotransmitter AgentsProtein BindingRecombinant Fusion ProteinsSpinal CordSynapsesSynaptic TransmissionSynaptic VesiclesSynaptosomal-Associated Protein 25ConceptsPlasma membraneSynaptic vesiclesSNAP-25Lamprey giant reticulospinal synapsePresynaptic plasma membraneSynaptic vesicle exocytosisLamprey reticulospinal synapseSNARE protein SNAP-25Protein SNAP-25Synaptic vesicle clustersNeurotransmitter releaseSNARE complexMolecular machineryVesicle exocytosisMembrane fusionVesicle cyclingPresynaptic microinjectionVesicle clustersSyntaxinPresynaptic membraneVesiclesElectron microscopic analysisAntibody-mediated disruptionMembraneMicroscopic analysis