Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior
Huang X, Xiaokaiti Y, Yang J, Pan J, Li Z, Luria V, Li Y, Song G, Zhu X, Zhang H, O'Donnell J, Xu Y. Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior. Neuropharmacology 2018, 143: 176-185. PMID: 30268520, DOI: 10.1016/j.neuropharm.2018.09.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsAnxiety DisordersCell LineCorticosteroneCyclic Nucleotide Phosphodiesterases, Type 2Depressive DisorderDose-Response Relationship, DrugHippocampusImidazolesMaleMice, Inbred ICRNADPH Oxidase 2NADPH OxidasesNeuronsOxidative StressPhosphodiesterase InhibitorsPsychotropic DrugsReactive Oxygen SpeciesTriazinesConceptsAnxiolytic-like effectsBAY 60Oxidative stressNADPH oxidase inhibitor apocyninPDE2 inhibitor Bay 60Prevalence of depressionOxidase inhibitor apocyninPhosphodiesterase 2Stress-related depressionAnxiety-like behaviorSource of ROSBDNF levelsNeuroprotective mechanismsStressed miceInhibitor apocyninCAMP/cGMPNADPH subunitsBehavioral abnormalitiesGp91phox expressionAntioxidant strategiesPDE2 inhibitionAntioxidant defenseDepressionGp91phoxVivo tests