EphB2 Deficiency Induces Depression-Like Behaviors and Memory Impairment: Involvement of NMDA 2B Receptor Dependent Signaling
Zhen L, Shao T, Luria V, Li G, Li Z, Xu Y, Zhao X. EphB2 Deficiency Induces Depression-Like Behaviors and Memory Impairment: Involvement of NMDA 2B Receptor Dependent Signaling. Frontiers In Pharmacology 2018, 9: 862. PMID: 30131699, PMCID: PMC6090375, DOI: 10.3389/fphar.2018.00862.Peer-Reviewed Original ResearchDepression-like behaviorMemory impairmentN-methyl-D-aspartate receptorsReceptor tyrosine kinase EphB2Adult hippocampal neurogenesisNMDA receptor subtypesWild-type littermatesMorris water mazeReceptor-dependent signalingImportant candidate targetEphB2 functionHippocampal neurogenesisNeurotrophic factorKO miceReceptor subtypesNeurogenic nicheExcitatory neuronsTail suspensionBehavioral alterationsBehavioral abnormalitiesCognitive disordersWater mazeNeuropsychiatric disordersCognitive deficitsProgenitor neurons