2014
Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation
Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes & Development 2014, 28: 983-994. PMID: 24732379, PMCID: PMC4018496, DOI: 10.1101/gad.236554.113.Peer-Reviewed Original ResearchConceptsStem cell quiescenceStem cell nicheHair follicle (HF) SCsTranscription factor nuclear factorJAK/STAT5Hormonal signalingMolecular circuitryActivated T cells c1Phosphatase calcineurinCell nicheSC quiescenceCell quiescenceT cells c1Calcineurin/NFATc1Function experimentsGenetic changesCanonical activationPharmacological lossPRL injectionsSC activationProlactin receptorMost tissuesTissue environmentHF SCsNuclear factor
2008
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells. Cell 2008, 132: 299-310. PMID: 18243104, PMCID: PMC2546702, DOI: 10.1016/j.cell.2007.11.047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34BiomarkersCell NucleusCell ProliferationCells, CulturedCyclin-Dependent Kinase 4CyclosporineDown-RegulationEmbryo, MammalianGene DeletionGene ExpressionGene Expression Regulation, DevelopmentalGenes, ReporterHair FollicleImmunohistochemistryImmunosuppressive AgentsMiceMice, KnockoutMice, NudeMorphogenesisNFATC Transcription FactorsRetroviridaeRNA, MessengerSkinSkin TransplantationStem CellsTranscription FactorsTransgenesTransplantation, HomologousConceptsStem cellsHair growthCell quiescenceStem cell quiescenceExcessive hair growthFollicular growthNFATc1 signalingHair follicle stem cellsFollicle stem cellsGene ablationQuiescent adult stem cellsAdult stem cellsNFATc1Skin stem cellsFunctional roleCellsTissue homeostasisProliferationPatientsInjury