2024
656 Wnt signaling activation in mature dermal adipocytes stimulates lipolysis and alters ECM homeostasis
Ma Q, Segal E, Wyetzner R, Horsley V, Atit R. 656 Wnt signaling activation in mature dermal adipocytes stimulates lipolysis and alters ECM homeostasis. Journal Of Investigative Dermatology 2024, 144: s115. DOI: 10.1016/j.jid.2024.06.672.Peer-Reviewed Original Research
2021
Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4
Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4. Journal Of Investigative Dermatology 2021, 142: 1597-1606.e9. PMID: 34808238, PMCID: PMC9120259, DOI: 10.1016/j.jid.2021.10.025.Peer-Reviewed Original ResearchConceptsWnt/β-catenin-responsive geneWnt activationExtracellular matrix homeostasisGenetic evidenceHuman fibrotic diseasesLipid-filled cellsFunctional mediatorsExtracellular matrixDermal adipocytesMatrix homeostasisGenetic modelsNew targetsWntKey targetMechanisms of fibrosisFibrotic diseasesTherapeutic avenuesDermal remodelingExtracellular matrix expansionExcessive accumulationRemodelingFibrosis severitySkin fibrosisFibrotic remodelingDPP4 inhibitors
2009
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection
Horsley V. Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection. Journal Of Cell Biology 2009, 185: 761-763. PMID: 19487452, PMCID: PMC2711585, DOI: 10.1083/jcb.200904125.Peer-Reviewed Original Research