2024
Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death
Cersonsky T, Ayala N, Tucker N, Saade G, Dudley D, Pinar H, Silver R, Reddy U, Lewkowitz A. Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2024, 303: 159-164. PMID: 39488137, PMCID: PMC11602338, DOI: 10.1016/j.ejogrb.2024.10.037.Peer-Reviewed Original ResearchRisk of stillbirthCause of deathIncreased risk of stillbirthHypertensive disordersPrenatal visit scheduleStillbirth Collaborative Research NetworkHigher risk of stillbirthSuboptimal prenatal careHypertensive disorders of pregnancyAssociated with higher riskDisorders of pregnancyVisit adherenceVisitation guidelinesPrenatal careSecondary analysisNon-adherenceVisit scheduleStillbirthIncreased riskMultivariate regressionStudy objectiveVisit frequencyPregnancyAdherenceGuidelines
2023
Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination
Cersonsky T, Silver R, Saade G, Dudley D, Reddy U, Pinar H. Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination. Placenta 2023, 140: 60-65. PMID: 37536149, PMCID: PMC10530266, DOI: 10.1016/j.placenta.2023.07.296.Peer-Reviewed Original ResearchConceptsFetal vascular malperfusionMaternal vascular malperfusionVascular malperfusionLive birthsFVM lesionsGestational ageMacroscopic findingsAmsterdam Placental Workshop Group Consensus StatementStillbirth Collaborative Research NetworkMicroscopic histopathological examinationMicroscopic pathologic evaluationHistory of hypertensionOdds of stillbirthGroup Consensus StatementMultivariate logistic regressionMVM lesionsPathologic evaluationHistopathological examinationMaternal raceOdds ratioConsensus statementHigher oddsUmbilical cordStillbirthMaternal factorsPlacental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network
Cersonsky T, Cersonsky R, Saade G, Silver R, Reddy U, Goldenberg R, Dudley D, Pinar H. Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network. Placenta 2023, 137: 59-64. PMID: 37080046, PMCID: PMC10192128, DOI: 10.1016/j.placenta.2023.04.005.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkGestational agePlacental lesionsDifferent gestational agesCollaborative research networksResearch NetworkTerm stillbirthFetal mortalityPlacental featuresHistologic changesStillbirthLesionsWeeksStandard protocolPlacentaFurther investigationAgePrincipal covariatesPrevious studiesGestationMortality
2022
Copy number variants and fetal growth in stillbirths
Dalton S, Workalemahu T, Allshouse A, Page J, Reddy U, Saade G, Pinar H, Goldenberg R, Dudley D, Silver R. Copy number variants and fetal growth in stillbirths. American Journal Of Obstetrics And Gynecology 2022, 228: 579.e1-579.e11. PMID: 36356697, PMCID: PMC10149588, DOI: 10.1016/j.ajog.2022.11.1274.Peer-Reviewed Original ResearchConceptsAbnormal copy number variantsFetal growth abnormalitiesGestational ageOdds ratioStillbirth Collaborative Research NetworkGenetic abnormalitiesChromosomal microarrayGestational age outcomesGestational age infantsGrowth abnormalitiesClinical risk factorsCohort study designAdjusted odds ratioCopy number variantsUnknown clinical significancePathogenic copy number variantsPlacental insufficiencyAge infantsNumber variantsFetal growthMaternal ageRisk factorsClinical significanceHigh incidenceStillbirth
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch Network
2020
161: Risk factors for Recurrent Stillbirth (SB): Results from the Stillbirth Collaborative Research Network (SCRN)
Whitham M, Gammon E, Chronister B, Urban A, Silver R, Reddy U, Dudley D. 161: Risk factors for Recurrent Stillbirth (SB): Results from the Stillbirth Collaborative Research Network (SCRN). American Journal Of Obstetrics And Gynecology 2020, 222: s116-s117. DOI: 10.1016/j.ajog.2019.11.177.Peer-Reviewed Original ResearchStillbirth Collaborative Research NetworkRecurrent stillbirthRisk factorsCollaborative research networksStillbirthResearch Network
2018
Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network
Harrison MS, Thorsten VR, Dudley DJ, Parker CB, Koch MA, Hogue CJR, Stoll BJ, Silver RM, Varner MW, Pinar MH, Coustan DR, Saade GR, Bukowski RK, Conway DL, Willinger M, Reddy UM, Goldenberg RL. Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network. American Journal Of Perinatology 2018, 35: 1071-1078. PMID: 29609190, PMCID: PMC6436964, DOI: 10.1055/s-0038-1639340.Peer-Reviewed Original ResearchConceptsWhite blood cell countElevated white blood cell countBody mass indexBlood cell countSerum ferritin levelsC-reactive protein levelsNormal body mass indexMaternal serum ferritinInflammatory markersNormal-weight womenHistologic chorioamnionitisC-reactive proteinSerum ferritinLive birthsFerritin levelsCell countLogistic regression modelsWeight womenBMI categoriesCategories of BMIMaternal serum ferritin levelsStillbirth Collaborative Research NetworkPrepregnancy body mass indexElevated body mass indexLogistic regressionPotentially Preventable Stillbirth in a Diverse U.S. Cohort
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstetrics And Gynecology 2018, 131: 336-343. PMID: 29324601, PMCID: PMC5785410, DOI: 10.1097/aog.0000000000002421.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPreventable stillbirthsPlacental insufficiencyHypertensive disordersMultiple gestationsMedical complicationsPopulation-based case-control studyDiverse U.S. cohortSpontaneous preterm birthMedical record abstractionWeeks of gestationCases of stillbirthCase-control studyCollaborative research networksResearch NetworkStillbirth reductionPreterm laborPreterm birthPlacental pathologyRecord abstractionNonanomalous fetusesMaternal interviewsPostmortem examinationU.S. cohortStillbirth
2017
Diagnostic Tests for Evaluation of Stillbirth
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Hogue C, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth. Obstetrics And Gynecology 2017, 129: 699-706. PMID: 28333795, DOI: 10.1097/aog.0000000000001937.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkCause of deathAntiphospholipid antibodiesPlacental pathologyDiagnostic testsEvaluation of stillbirthMedical record abstractionPopulation-based studyCollaborative research networksDeath classification systemResearch NetworkRecord abstractionSyphilis serologyClinical presentationToxicology screenAntibody screenClinical historyMaternal interviewsStillbirthSecondary analysisGenetic testingUseful testBiospecimen collectionStandardized evaluationMost participants
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGHFactor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network
Silver RM, Saade GR, Thorsten V, Parker CB, Reddy UM, Drews-Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Hogue C, Pinar H, Varner MW, Goldenberg R, Willinger M. Factor V Leiden, prothrombin G20210A, and methylene tetrahydrofolate reductase mutations and stillbirth: the Stillbirth Collaborative Research Network. American Journal Of Obstetrics And Gynecology 2016, 215: 468.e1-468.e17. PMID: 27131585, DOI: 10.1016/j.ajog.2016.04.026.Peer-Reviewed Original ResearchConceptsFactor V LeidenStillbirth Collaborative Research NetworkCase-control studyHeritable thrombophiliaV LeidenProthrombin G20210AFetal thrombophiliaOdds ratioPAI-1 4G/4G polymorphismPopulation-based case-control studyMaternal factor V LeidenHomozygous factor V Leiden mutationFactor V Leiden mutationEvaluation of stillbirthTetrahydrofolate reductase mutationOdds of stillbirthV Leiden mutationTetrahydrofolate reductase C677TCollaborative research networksReductase C677TResearch NetworkMaternal thrombophiliaThrombophilia markersSingleton pregnanciesIncreased odds
2014
Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy
Varner MW, Silver RM, Hogue C, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM. Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy. Obstetrics And Gynecology 2014, 123: 113-125. PMID: 24463671, PMCID: PMC3931517, DOI: 10.1097/aog.0000000000000052.Peer-Reviewed Original ResearchConceptsIllicit drug useCotinine assaysDrug useMaternal serum cotinine levelStillbirth Collaborative Research NetworkCannabis useSelf-reported smoking historyRisk of stillbirthLive-birth deliveriesSerum cotinine levelsCase-control studySecond-hand smokeUmbilical cord samplesIllicit drugsDose-response relationshipStillbirth deliverySmoking historyCotinine levelsMaternal serumSerum cotinineBirth deliveryCord homogenateSmoking useCord samplesStillbirth
2013
Bile acids in a multicenter, population-based case-control study of stillbirth
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. American Journal Of Obstetrics And Gynecology 2013, 210: 460.e1-460.e9. PMID: 24215860, PMCID: PMC4413928, DOI: 10.1016/j.ajog.2013.11.017.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyBile acid levelsCase-control studyLive birthsBile acidsStillbirth Collaborative Research NetworkAcid levelsBaseline risk factorsTerm live birthsPopulation-based studyCases of stillbirthTime of enrollmentProportion of womenMaternal serumClinical evidenceIntrahepatic cholestasisRisk factorsFetal anomaliesStillbirthElevated levelsWomenBirthSimilar proportionsCollaborative research networksResearch NetworkKaryotype Versus Microarray Testing for Genetic Abnormalities After Stillbirth
Reddy U, Page G, Saade G, Silver R, Thorsten V, Parker C, Pinar H, Willinger M, Stoll B, Heim-Hall J, Varner M, Goldenberg R, Bukowski R, Wapner R, Drews-Botsch C, O’Brien B, Dudley D, Levy B. Karyotype Versus Microarray Testing for Genetic Abnormalities After Stillbirth. Obstetrical & Gynecological Survey 2013, 68: 278-280. DOI: 10.1097/01.ogx.0000429295.65513.69.Peer-Reviewed Original ResearchMicroarray analysisUnknown significancePathogenic variantsAntepartum stillbirthPostmortem examinationKaryotype analysisMore abnormalitiesPlacental tissueMicroarray resultsStillbirth Collaborative Research NetworkBenign variantsMicroarray testingPopulation-based studyGenomic abnormalitiesGeographic catchment areaStandard karyotype analysisCopy number variantsCord bloodClinical significanceNonviable tissueClinical relevanceStillbirthAbnormal karyotypeClinical implicationsFetal tissuesAn Algorithm for the Estimation of Gestational Age at the Time of Fetal Death
Conway DL, Hansen NI, Dudley DJ, Parker CB, Reddy UM, Silver RM, Bukowski R, Pinar H, Stoll BJ, Varner MW, Saade GR, Hogue C, Willinger M, Coustan D, Koch MA, Goldenberg RL, Network E. An Algorithm for the Estimation of Gestational Age at the Time of Fetal Death. Paediatric And Perinatal Epidemiology 2013, 27: 145-157. PMID: 23374059, PMCID: PMC3564237, DOI: 10.1111/ppe.12037.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkFetal foot lengthFetal deathGestational agePopulation-based case-control studyFoot lengthWeeks of diagnosisCase-control studyGeographical catchment areasSingleton stillbirthsStillbirth casesPost-mortem dataStillbirthClinical practiceMore weeksDeathWeeksCollaborative research networksDiagnosisResearch NetworkShort intervalsLivebirthsWomen
2012
Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth
Reddy UM, Page GP, Saade GR, Silver RM, Thorsten VR, Parker CB, Pinar H, Willinger M, Stoll BJ, Heim-Hall J, Varner MW, Goldenberg RL, Bukowski R, Wapner RJ, Drews-Botsch CD, O'Brien BM, Dudley DJ, Levy B. Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth. New England Journal Of Medicine 2012, 367: 2185-2193. PMID: 23215556, PMCID: PMC4295117, DOI: 10.1056/nejmoa1201569.Peer-Reviewed Original ResearchConceptsGenetic abnormalitiesAntepartum stillbirthCongenital anomaliesMicroarray analysisStillbirth Collaborative Research NetworkCopy number variantsAnalysis of stillbirthPopulation-based studyKaryotype analysisResults of karyotypeGeographic catchment areaSingle nucleotide polymorphism arrayClinical significancePostmortem examinationNonviable tissueStillbirthTrue prevalenceFetal tissuesUnaffected personsAbnormalitiesKaryotype resultsMicroarray testingCollaborative research networksGenetic diagnosisPolymorphism array
2011
Stillbirth Collaborative Research Network: design, methods and recruitment experience
Parker CB, Hogue CJ, Koch MA, Willinger M, Reddy UM, Thorsten VR, Dudley DJ, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter M, Goldenberg R, Network F. Stillbirth Collaborative Research Network: design, methods and recruitment experience. Paediatric And Perinatal Epidemiology 2011, 25: 425-435. PMID: 21819424, PMCID: PMC3665402, DOI: 10.1111/j.1365-3016.2011.01218.x.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPost-mortem examinationMaternal interviewsPlacental pathological examinationMedical record abstractionCase-control studyCase-control study participantsTime of deliveryHigher consent ratesGeographical catchment areasRecruitment experienceRecruitment hospitalChart abstractionProspective enrollmentPlacental pathologyRecord abstractionWeeks' gestationPathological examinationRisk factorsConsent ratesLivebirthsStillbirthClinical sitesStudy participantsAdditional surveillance2: Stillbirth Collaborative Research Network: genetic changes identified in stillbirths using molecular cytogenetic technology
Reddy U. 2: Stillbirth Collaborative Research Network: genetic changes identified in stillbirths using molecular cytogenetic technology. American Journal Of Obstetrics And Gynecology 2011, 204: s2. DOI: 10.1016/j.ajog.2010.10.008.Peer-Reviewed Original ResearchStillbirth Collaborative Research Network
2010
A New System for Determining the Causes of Stillbirth
Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade GR, Varner MW, Pinar H, Coustan D, Bukowski R, Stoll B, Koch MA, Parker CB, Reddy UM. A New System for Determining the Causes of Stillbirth. Obstetrics And Gynecology 2010, 116: 254-260. PMID: 20664383, PMCID: PMC3832680, DOI: 10.1097/aog.0b013e3181e7d975.Peer-Reviewed Original ResearchConceptsCause of deathStillbirth Collaborative Research NetworkFetal deathInitial causePlacental pathologic findingsPlacental pathology dataCauses of stillbirthMaternal medical conditionsMedical record abstractionStrict diagnostic criteriaHistologic chorioamnionitisObstetric complicationsPlacental infectionFetal infectionPlacental pathologyRecord abstractionGestational agePathologic findingsPathophysiologic sequencePrenatal careClinical evaluationHematologic conditionsMaternal interviewsPostmortem examinationMedical conditions
2007
Work-up of stillbirth: a review of the evidence
Silver RM, Varner MW, Reddy U, Goldenberg R, Pinar H, Conway D, Bukowski R, Carpenter M, Hogue C, Willinger M, Dudley D, Saade G, Stoll B. Work-up of stillbirth: a review of the evidence. American Journal Of Obstetrics And Gynecology 2007, 196: 433-444. PMID: 17466694, PMCID: PMC2699761, DOI: 10.1016/j.ajog.2006.11.041.Peer-Reviewed Original ResearchConceptsCauses of stillbirthStillbirth Collaborative Research NetworkFetal-maternal hemorrhageWeeks of gestationUtero fetal deathProportion of stillbirthsFetal deathIntrapartum carePrecise etiologyMedical conditionsChild healthStillbirthAcademic centersDiagnostic testsGenetic abnormalitiesNational InstituteCollaborative research networksResearch NetworkUnited StatesDiagnostic explanationCauseSystematic evaluationHemorrhageReviewGestation