2024
Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks, Gestation
Woolcock H, Parra N, Zhang Y, Reddy U, Bello N, Miller E, Booker W. Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks, Gestation. American Journal Of Perinatology 2024, 41: 2135-2143. PMID: 38569509, PMCID: PMC11496016, DOI: 10.1055/a-2298-5347.Peer-Reviewed Original ResearchAssociated with adverse pregnancy outcomesFetal growth restrictionPlacental abruptionWeeks gestationBlood pressureElevated BPAmerican Heart AssociationPregnancy outcomesNormal BPOdds of fetal growth restrictionIncreased riskOdds of placental abruptionAmerican CollegeMultivariable-adjusted odds ratioAssociated with HDPAdverse pregnancy outcomesWeeks of pregnancyProspective cohort studyElevated blood pressureConfidence intervalsStage I hypertensionAmerican College of Cardiology (ACCCesarean deliveryPreterm deliverySingleton pregnancies
2023
Risk factors and perinatal outcomes for persistent placenta previa in nulliparas
Post R, Chang J, Ziogas A, Crosland B, Silver R, Haas D, Grobman W, Saade G, Reddy U, Simhan H, Chung J. Risk factors and perinatal outcomes for persistent placenta previa in nulliparas. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101136. PMID: 37598887, DOI: 10.1016/j.ajogmf.2023.101136.Peer-Reviewed Original ResearchPersistent placenta previaPlacenta previaMidtrimester ultrasoundRisk factorsPrevious pregnancyCesarean deliveryMaternal ageNulliparous Pregnancy Outcomes StudyLower neonatal birthweightOlder maternal agePrevious cesarean deliveryProspective cohort studyPregnancy Outcomes StudySignificant risk factorsMultivariate logistic regressionNulliparous individualsPrevious dilationNeonatal birthweightNeonatal outcomesPerinatal outcomesPreterm deliveryBaseline characteristicsCohort studyThird trimesterAntepartum admissionsCervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasoundPROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
Thom E, Saade G, Askie L, Ugwu L, Mol B, Vayssiere C, Norman J, Pajkrt E, Clifton R, Biggio J, Arnaud C, Berghella V, Canino M, Carreras E, Dugoff L, Hoffman M, Pacagnella R, Reddy U, Saccone G, van 't Hooft J, Dang V, Collaboration F. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. American Journal Of Perinatology 2023, 41: e2230-e2237. PMID: 37429323, PMCID: PMC10776795, DOI: 10.1055/s-0043-1771018.Peer-Reviewed Original ResearchShort cervical lengthPreterm birthIndividual patient dataShort cervixRandomized trialsPessary trialCervical lengthTwin gestationsSubsequent spontaneous preterm birthLong-term neurological disabilityOngoing randomized trialsSpontaneous preterm birthTrial study protocolWeeks of gestationProspective Meta-AnalysisSignificant health issueCervical supportNeonatal morbidityPreterm deliverySingleton gestationsSecondary outcomesFetal deathNeurological disabilityPrimary outcomeWeeks' gestationShort-term neonatal outcomes of pregnancies complicated by maternal obesity
Dinsmoor M, Ugwu L, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Short-term neonatal outcomes of pregnancies complicated by maternal obesity. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100874. PMID: 36690180, PMCID: PMC10065915, DOI: 10.1016/j.ajogmf.2023.100874.Peer-Reviewed Original ResearchConceptsComposite neonatal morbidityNeonatal outcomesBody mass indexWeeks of gestationMaternal obesityNeonatal morbidityMorbid obesityMass indexReference groupIntraventricular hemorrhage grade 3Short-term neonatal outcomesCohort of deliveriesComposite neonatal outcomeSuper morbid obesityHypoxic-ischemic encephalopathyPrevious cesarean deliveryRespiratory distress syndromeChronic hypertensionPreterm deliveryBaseline characteristicsCesarean deliveryComposite outcomeMaternal heightMaternal preeclampsiaObese patients
2022
Neonatal outcomes by delivery indication after administration of antenatal late preterm corticosteroids
Deshmukh U, Lundsberg L, Pettker C, Rouse D, Reddy U. Neonatal outcomes by delivery indication after administration of antenatal late preterm corticosteroids. AJOG Global Reports 2022, 2: 100097. PMID: 36536839, PMCID: PMC9758401, DOI: 10.1016/j.xagr.2022.100097.Peer-Reviewed Original ResearchPreterm prelabor ruptureLate preterm deliveryPreterm delivery groupLate preterm periodNeonatal respiratory complicationsPreterm labor groupPreterm deliverySpontaneous preterm laborPreterm laborPrelabor rupturePrimary outcomeDelivery indicationsDelivery groupAntenatal corticosteroidsNeonatal complicationsPlacebo groupRespiratory complicationsPreterm periodLower oddsAntenatal Late Preterm Steroids trialNewborn intensive care unit admissionIntensive care unit admissionMultivariable logistic regression modelLate preterm infantsNeonatal respiratory outcomes
2021
Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study
Grover S, Brandt J, Reddy U, Ananth C. Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 572-579. PMID: 34536318, PMCID: PMC9214277, DOI: 10.1111/1471-0528.16932.Peer-Reviewed Original ResearchConceptsPerinatal mortality rateChronic hypertensionEarly term deliveryPreterm deliveryPerinatal mortalityMortality rateTerm deliverySingleton birthsCausal mediation analysisMaternal chronic hypertensionElevated blood pressureModifiable risk factorsPopulation-based studyWeeks of gestationLate-term gestationCross-sectional analysisNormotensive pregnanciesPreterm birthBlood pressureTerm gestationPerinatal deathRisk factorsHypertensionMAIN OUTCOMEMortality
2019
Early Preterm Preeclampsia Outcomes by Intended Mode of Delivery
Coviello E, Iqbal S, Grantz K, Huang C, Landy H, Reddy U. Early Preterm Preeclampsia Outcomes by Intended Mode of Delivery. Obstetric Anesthesia Digest 2019, 39: 187-188. DOI: 10.1097/01.aoa.0000603672.77426.4d.Peer-Reviewed Original ResearchSevere featuresEarly preterm deliveryEarly preterm preeclampsiaEarly preterm birthElevated liver enzymesSyndrome of hemolysisIntended modePreeclampsia outcomesNeonatal outcomesPregnant patientsPreterm deliveryPreterm preeclampsiaPreterm birthLow plateletsMaternal mortalityLiver enzymesPaucity of studiesPreeclampsiaOutcomesDeliveryEclampsiaMorbidityPatientsPregnancySyndromePredictors of Sleep-disordered Breathing in Pregnancy
Louis J, Koch M, Reddy U, Silver R, Parker C, Facco F, Redline S, Nhan-Chang C, Chung J, Pien G, Basner R, Grobman W, Wing D, Simhan H, Haas D, Mercer B, Parry S, Mobley D, Carper B, Saade G, Schubert F, Zee P. Predictors of Sleep-disordered Breathing in Pregnancy. Obstetric Anesthesia Digest 2019, 39: 36-37. DOI: 10.1097/01.aoa.0000552909.82459.b1.Peer-Reviewed Original ResearchSleep-disordered breathingDiagnosis of SDBSevere maternal morbidityRisk of complicationsMaternal morbidityPreterm deliverySDB symptomsVenous thromboembolismMaternal deathsOvernight polysomnographyPregnant womenAdverse outcomesLarge cohortFeasible prediction modelPregnancyBreathingWomenThromboembolismPreeclampsiaMorbidityComplicationsPolysomnographyCohortSymptomsDiagnosis
2017
Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women
Esplin M, Elovitz M, Iams J, Parker C, Wapner R, Grobman W, Simhan H, Wing D, Haas D, Silver R, Hoffman M, Peaceman A, Caritis S, Parry S, Wadhwa P, Foroud T, Mercer B, Hunter S, Saade G, Reddy U. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. Obstetric Anesthesia Digest 2017, 37: 204. DOI: 10.1097/01.aoa.0000527046.29057.df.Peer-Reviewed Original ResearchFetal fibronectin levelsCervical lengthPreterm deliveryFibronectin levelsProspective observational cohort studyTransvaginal cervical lengthObservational cohort studySpontaneous preterm birthSpontaneous preterm deliveryNulliparous pregnant womenLong-term health effectsSpontaneous premature birthHigher medical costsCohort studyFetal fibronectinNulliparous womenPreterm birthPremature birthPregnant womenCervicovaginal fluidSerial measurementsUniversal screeningMedical costsMajor causeHealth effects
2016
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery
Gyamfi-Bannerman C, Thom E, Blackwell S, Tita A, Reddy U, Saade G, Rouse D, McKenna D, Clark E, Thorp J, Chien E, Peaceman A, Gibbs R, Swamy G, Norton M, Casey B, Caritis S, Tolosa J, Sorokin Y, VanDorsten J, Jain L. Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. Obstetrical & Gynecological Survey 2016, 71: 453-455. DOI: 10.1097/01.ogx.0000489576.69844.54.Peer-Reviewed Original ResearchLate preterm periodPreterm periodMaternal-Fetal Medicine Units NetworkEunice Kennedy Shriver National InstituteLate preterm deliveryAdministration of betamethasoneAntenatal betamethasoneNeonatal morbidityPreterm deliveryMulticenter trialClinical centersChildhood complicationsChild healthNational InstituteBetamethasoneWomenRiskMorbidityComplicationsNewbornsInfantsAdministrationTrials
2015
A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery
Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthMaternal single nucleotide polymorphismsSPTB casesPreterm birthValidation cohortSingle nucleotide polymorphismsEarly spontaneous preterm deliveryP-valueTerm controlsTerm delivery controlsSpontaneous preterm deliveryMother-infant pairsCase-control studyIndependent validation cohortRace/ethnicityPreterm deliveryInfant morbidityMaternal ageControl groupMultiple testing adjustmentMultiple comparisonsCohortBirthNucleotide polymorphismsGenome-wide association studies
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sites
2012
Neonatal Mortality by Attempted Route of Delivery in Early Preterm Birth
Reddy U, Zhang J, Sun L, Chen Z, Raju T, Laughon S. Neonatal Mortality by Attempted Route of Delivery in Early Preterm Birth. Obstetrical & Gynecological Survey 2012, 67: 677-678. DOI: 10.1097/01.ogx.0000423178.72381.e3.Peer-Reviewed Original ResearchVaginal deliveryCesarean deliveryWeeks of gestationNeonatal mortalityRoute of deliveryPreterm laborBreech presentationEarly preterm deliveryEarly preterm laborRecent cohort dataVertex-presenting fetusesEarly preterm birthTrial of laborPreterm premature ruptureBreech-presenting fetusesSmall randomized trialsMode of deliveryHigh neonatal mortalityAbstract InfantsFetal indicationsPreterm deliveryPreterm birthSingleton deliveriesVertex presentationNeonatal death