2019
Impact of High K Intake on Thiazide‐Sensitive Cation Excretion in Male and Female Wild‐type and AT1a Receptor Knockout Mice
Li J, Xu S, Wang C, Weinstein A, Palmer L, Wang T. Impact of High K Intake on Thiazide‐Sensitive Cation Excretion in Male and Female Wild‐type and AT1a Receptor Knockout Mice. The FASEB Journal 2019, 33: 864.4-864.4. DOI: 10.1096/fasebj.2019.33.1_supplement.864.4.Peer-Reviewed Original ResearchNa/H exchanger isoform 3Na-Cl co-transporterFemale wild-typeGlomerular filtration rateKO miceCation excretionNa/H exchangeDistal NaAng IIUrine volumeFemale miceThiazide-sensitive Na-Cl co-transporterApical membrane of distal tubulesAT1a receptor knockout miceHK dietWild-typeResponse to high KAT1a-KO miceK + excretionReceptor knockout miceDistal nephron segmentsFemale KO miceGroups of miceRenal clearance experimentsAT1A KO
2008
ANGIOTENSION‐INDUCED HYPERTENSION AND CHANGES IN RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE
Yan Q, Raksaseri P, Weldon S, Kabcenell A, Hebert S, Wang T. ANGIOTENSION‐INDUCED HYPERTENSION AND CHANGES IN RENAL FUNCTIONS IN MALE AND FEMALE sEH KNOCKOUT MICE. The FASEB Journal 2008, 22: 941.15-941.15. DOI: 10.1096/fasebj.22.1_supplement.941.15.Peer-Reviewed Original ResearchInfusion of Ang IIFemale WT miceChronic infusion of Ang IIMale WT miceWT miceAng IIFemale KO miceKO miceChronic infusionBlood pressureMale WTMale KOMm HgAng II-induced hypertensionEffects of Ang IISEH-knockout miceAng II infusionResponse to AngII-induced hypertensionFemale wild-typeSystemic blood pressureGroups of miceWild-typeLower blood pressureSEH-knockout
2003
Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule
Du Z, Ferguson W, Wang T. Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule. American Journal Of Physiology. Renal Physiology 2003, 284: f688-f692. PMID: 12527554, DOI: 10.1152/ajprenal.00261.2002.Peer-Reviewed Original ResearchConceptsConcentrations of Ang IIAng IIProximal tubulesFluid absorptionTMB-8Effect of luminal ANGLow concentrations of Ang IIEffects of Ang IIEffects of angiotensin IIProximal tubules in vitroProximal tubule transportProximal tubules of ratsInhibit Na(+) transportIntracellular calcium mobilizationAng II concentrationsTubules of ratsCAMP-independent mechanismConcentrations of ANGNa(+) transportTubules in vitroProximal tubular fluidIntracellular Ca(2Intracellular calciumTubule transportLuminal ANG
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsEffects of Ang IIAng IILate distal tubuleDistal tubulesDecreased JvAngiotensin IIHigher dose of Ang IILow doses of angiotensin IILuminal application of amilorideAmiloride-sensitive Na+ transportDose of Ang IIRat kidneyHCO3- transportAddition of ANG IIDoses of angiotensin IIEffects of angiotensin IIApplication of amilorideStimulate Na+/H+ exchangeProximal tubules of rat kidneyDistal convoluted tubuleLuminal administrationNa+ channelsNa+/H+ exchangeDistal nephronIntravenous infusion
1991
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Wang T, Chan Y. The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1991, 256: 309-17. PMID: 1846421.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IIAnimalsBicarbonatesBiological TransportCalcium Channel BlockersDose-Response Relationship, DrugGallic AcidIsoquinolinesKidney Tubules, ProximalMalePerfusionPhosphatidylinositolsPiperazinesProtein Kinase InhibitorsRatsRats, Inbred StrainsSignal TransductionSodiumTetradecanoylphorbol AcetateConceptsEffects of Ang IIProximal convoluted tubulesAng IITMB-8Biphasic effectAngiotensin IISodium transportStimulatory effect of Ang IIPhosphoinositide turnoverN-diethylamino)-octyl-3,4,5-trimethoxybenzoateDose-dependent biphasic effectEffects of angiotensin IIRat proximal convoluted tubuleIntracellular calcium mobilizationRenal tubular transportOriginal perfusatePerfusion in vivoIntracellular calciumNa+/H+ exchangeCalcium mobilizationJHCO3Fluid reabsorptionConvoluted tubulesLuminal perfusionRat kidney
1990
Mechanism of angiotensin II action on proximal tubular transport.
Wang T, Chan Y. Mechanism of angiotensin II action on proximal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1990, 252: 689-95. PMID: 2313594.Peer-Reviewed Original ResearchConceptsBeta-phorbol-12-myristate-13-acetateAng II actionAng IIFluid reabsorptionLow doses of angiotensin IINa-H exchange mechanismPhosphoinositide turnoverLuminal perfusionDoses of angiotensin IIAng II antagonistRat proximal tubulesProximal tubular transportAngiotensin II actionAction of angiotensinOriginal perfusatePerfusion in vivoApical membraneProximal tubulesBicarbonate absorptionAngiotensin IIJHCO3Low dosesApical sideNa-HAng