2022
A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus‐like Disease in Mice
Meas R, Nititham J, Taylor KE, Maher S, Clairmont K, Carufe KEW, Kashgarian M, Nottoli T, Cheong A, Nagel ZD, Gaffney PM, Criswell LA, Sweasy JB. A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus‐like Disease in Mice. ACR Open Rheumatology 2022, 4: 760-770. PMID: 35708944, PMCID: PMC9469486, DOI: 10.1002/acr2.11471.Peer-Reviewed Original ResearchSystemic lupus erythematosusAntinuclear antibodiesMSH6 variantsLupus erythematosusMSH6 mutationsMouse modelSingle nucleotide polymorphismsDevelopment of SLELevel of ANAInfiltration of CD68Lupus-like diseaseInflammatory lung diseasesLung alveolar spacesRepair genesMismatch repair genesLung diseaseHealthy controlsPeyer's patchesWildtype miceAlveolar spaceCRISPR/Cas9 gene targetingSomatic hypermutation frequenciesAutoimmune phenotypeMiceDifferent mismatch repair genes
2006
Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
Chen R, Tilley MR, Wei H, Zhou F, Zhou FM, Ching S, Quan N, Stephens RL, Hill ER, Nottoli T, Han DD, Gu HH. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 9333-9338. PMID: 16754872, PMCID: PMC1482610, DOI: 10.1073/pnas.0600905103.Peer-Reviewed Original ResearchConceptsRole of DATFunctional dopamine transporterDopamine transporterCocaine rewardSerotonin transporterNorepinephrine transporterExtracellular DAKnockout miceCocaine-insensitive dopamine transporterRole of NETNET knockout miceDAT knockout miceSelf-administer cocaineKnockin mouse lineMouse modelNucleus accumbensDopamine hypothesisPlace preferenceDA hypothesisLocomotor activityReward pathwayBehavioral effectsMiceMouse lines