2009
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling
Lai D, Wan M, Wu J, Preston-Hurlburt P, Kushwaha R, Grundström T, Imbalzano AN, Chi T. Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1169-1174. PMID: 19164553, PMCID: PMC2633529, DOI: 10.1073/pnas.0811274106.Peer-Reviewed Original ResearchConceptsCalcium/CaMChromatin remodelingBAF complexSWI/SNF-like BAF chromatinTarget genesDominant negative mutantCalcium/calmodulinCalmodulin-dependent regulationHMG domainBAF chromatinCaM-binding peptideNegative mutantGene expressionCaM antagonistsGenesToll-like receptor 4ChromatinRegulationRemodelingRecruitmentComplexesBAF57RNAiMutantsInduction
2002
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
Chi TH, Wan M, Zhao K, Taniuchi I, Chen L, Littman DR, Crabtree GR. Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature 2002, 418: 195-199. PMID: 12110891, DOI: 10.1038/nature00876.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensCD8 AntigensChromatinCross-Linking ReagentsDNA HelicasesDNA-Binding ProteinsFlow CytometryGene Expression RegulationGene SilencingMacromolecular SubstancesMiceMice, TransgenicMutationNuclear ProteinsProtein BindingProtein Structure, TertiaryProtein SubunitsThymus GlandTranscription FactorsConceptsBAF complexCD4 silencerYeast SWI/SNF complexSWI/SNF-like BAF complexHigh mobility group domainSWI/SNF complexLineage-specific genesDNA-binding subunitLineage bifurcationChromatin remodellingHMG domainChromatin lociSNF complexDNA bendingReciprocal regulationGroup domainCD4/CD8 expressionCell killingThymic developmentSilencerMutationsComplexesExpressionBAF57BRG