Featured Publications
Witnessing Modern America: Violence and Racial Trauma
Williams JC, Holloway TD, Ross DA. Witnessing Modern America: Violence and Racial Trauma. Biological Psychiatry 2019, 86: e41-e42. PMID: 31668222, PMCID: PMC7220206, DOI: 10.1016/j.biopsych.2019.09.025.Peer-Reviewed Original ResearchEpigenetic Mechanisms of Serotonin Signaling
Holloway T, González-Maeso J. Epigenetic Mechanisms of Serotonin Signaling. ACS Chemical Neuroscience 2015, 6: 1099-1109. PMID: 25734378, PMCID: PMC4838281, DOI: 10.1021/acschemneuro.5b00033.Peer-Reviewed Original ResearchConceptsEpigenetic mechanismsHeritable epigenetic modificationsNumerous physiological responsesSignal transduction mechanismsReceptor-dependent signalingEpigenetic marksHistone modificationsGene functionEpigenetic modificationsDNA methylationCellular phenotypesGene expressionTransduction mechanismsPhysiological responsesFundamental roleDiverse setComplex interactionsCentral nervous systemRecent advancesFundamental questionsIntense researchMethylationNervous systemSignalingMechanismHDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience 2012, 15: 1245-1254. PMID: 22864611, PMCID: PMC3431440, DOI: 10.1038/nn.3181.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsAntipsychotic AgentsBenzamidesChromatin ImmunoprecipitationClozapineDNA MethylationGenetic VectorsHEK293 CellsHerpesvirus 2, HumanHistone Deacetylase 2HistonesHumansHydroxamic AcidsImmunohistochemistryMiceMice, KnockoutPatch-Clamp TechniquesPlasmidsPrefrontal CortexPromoter Regions, GeneticPyridinesReal-Time Polymerase Chain ReactionReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateReflex, StartleSchizophrenic PsychologyVorinostat
2021
Racial and Ethnic Differences in Psychiatry Resident Prescribing: a Quality Improvement Education Intervention to Address Health Equity
Cerdeña I, Holloway T, Cerdeña JP, Wing A, Wasser T, Fortunati F, Rohrbaugh R, Li L. Racial and Ethnic Differences in Psychiatry Resident Prescribing: a Quality Improvement Education Intervention to Address Health Equity. Academic Psychiatry 2021, 45: 13-22. PMID: 33495966, PMCID: PMC9942699, DOI: 10.1007/s40596-021-01397-z.Peer-Reviewed Original ResearchConceptsWhite patientsRace/ethnicityPrescriber profilesLatinx patientsEthnic differencesUnique patient encountersPrescription of antipsychoticsElectronic medical recordsAntidepressant prescriptionsAntipsychotic prescribingAntidepressant prescribingHigher diagnosisPrimary diagnosisMedical recordsDepression diagnosisMedication ordersClinical careLower oddsPatientsPsychotic disordersPatient encountersHealth disparitiesPrescribingConclusionsOur findingsEducation intervention
2013
HDAC2 as a new target to improve schizophrenia treatment
Kurita M, Holloway T, González-Maeso J. HDAC2 as a new target to improve schizophrenia treatment. Expert Review Of Neurotherapeutics 2013, 13: 1-3. PMID: 23253383, PMCID: PMC3552246, DOI: 10.1586/ern.12.141.Peer-Reviewed Original Research
2012
Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*. Journal Of Biological Chemistry 2012, 287: 44301-44319. PMID: 23129762, PMCID: PMC3531745, DOI: 10.1074/jbc.m112.413161.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid MotifsAmino Acid SequenceAmino Acid SubstitutionAnimalsBehaviorCase-Control StudiesDimerizationFemaleHumansMaleMiceMice, 129 StrainMice, KnockoutMiddle AgedMolecular Sequence DataProtein BindingReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaSchizophrenic PsychologySequence AlignmentYoung AdultConceptsFrontal cortexMetabotropic glutamate 2 receptorGPCR heteromersBehavioral functionsMouse frontal cortexPsychosis-like effectsHallucinogenic 5Receptor neurotransmissionSchizophrenic subjectsReceptor heteromerizationReceptor complex formationSerotoninCortexHeteromeric expressionReceptorsReceptor heterocomplexDomain fourHeteromeric complexesCell signalingThree residuesHeteromersIntracellular endNeurotransmissionAgonistsMice
2011
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
Albizu L, Holloway T, González-Maeso J, Sealfon SC. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology 2011, 61: 770-777. PMID: 21645528, PMCID: PMC3556730, DOI: 10.1016/j.neuropharm.2011.05.023.Peer-Reviewed Original ResearchConceptsMK-801-induced locomotor activityAlteration of serotoninDopamine D2 receptorsG protein-coupled receptor targetsFunctional crosstalkHEK293 cellsAntipsychotic effectsAntipsychotic drugsD2 receptorsSerotonin 5Dopamine systemLocomotor activityRadioligand bindingAgonist affinityReceptor targetsTherapeutic drugsReceptorsProduction assaysCo-immunoprecipitation studiesSerotoninReceptor heterocomplexDrugsActivationCellsAntagonist