2018
HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice
de la Fuente Revenga M, Ibi D, Saunders J, Cuddy T, Ijaz M, Toneatti R, Kurita M, Holloway T, Shen L, Seto J, Dozmorov M, González-Maeso J. HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice. Neuroscience 2018, 388: 102-117. PMID: 30025863, PMCID: PMC6129430, DOI: 10.1016/j.neuroscience.2018.07.010.Peer-Reviewed Original ResearchConceptsHDAC inhibitor SAHAChronic treatmentControl miceFrontal cortexSchizophrenia patientsSynaptic plasticityChronic antipsychotic drug exposureHistone deacetylase 2 (HDAC2) expressionGlutamatergic pyramidal neuronsChronic antipsychotic treatmentAntipsychotic drug exposureAntipsychotic drug actionNew therapeutic approachesConditional knockout micePlasticity-related genesAntipsychotic treatmentPyramidal neuronsDrug exposureAntipsychotic drugsFunctional synapsesHDAC2 functionTherapeutic approachesKnockout micePresynaptic terminalsSAHA treatment
2012
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology 2012, 225: 217-226. PMID: 22842765, PMCID: PMC3552490, DOI: 10.1007/s00213-012-2809-7.Peer-Reviewed Original ResearchConceptsChronic clozapineLysergic acid diethylamideAtypical antipsychotic drug actionHead-twitch behaviorC-fosAntipsychotic-like activityAntipsychotic drug actionTherapeutic-like effectsMouse somatosensory cortexSchizophrenia-like behavioral alterationsEgr-2Egr-1Chronic haloperidolChronic treatmentClozapine administrationDrug therapyOptimal treatmentSomatosensory cortexSingle administrationAntipsychotic drugsMurine modelMouse modelRodent modelsSerotonin 5Behavioral alterations
2011
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
Albizu L, Holloway T, González-Maeso J, Sealfon SC. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology 2011, 61: 770-777. PMID: 21645528, PMCID: PMC3556730, DOI: 10.1016/j.neuropharm.2011.05.023.Peer-Reviewed Original ResearchConceptsMK-801-induced locomotor activityAlteration of serotoninDopamine D2 receptorsG protein-coupled receptor targetsFunctional crosstalkHEK293 cellsAntipsychotic effectsAntipsychotic drugsD2 receptorsSerotonin 5Dopamine systemLocomotor activityRadioligand bindingAgonist affinityReceptor targetsTherapeutic drugsReceptorsProduction assaysCo-immunoprecipitation studiesSerotoninReceptor heterocomplexDrugsActivationCellsAntagonistMaternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring. Journal Of Neuroscience 2011, 31: 1863-1872. PMID: 21289196, PMCID: PMC3037097, DOI: 10.1523/jneurosci.4230-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdult ChildrenAnimalsAntipsychotic AgentsCerebral CortexDisease Models, AnimalDown-RegulationEarly Growth Response Protein 1Early Growth Response Protein 2FemaleFrontal LobeGlutamic AcidHallucinogensInfluenza A Virus, H1N1 SubtypeMaternal-Fetal ExchangeMiceNeural PathwaysOrthomyxoviridae InfectionsPregnancyProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaUp-RegulationConceptsInfluenza viral infectionViral infectionMouse modelAdult offspringSchizophrenia-like alterationsPrenatal viral infectionHead-twitch responseSchizophrenia-like psychosisInfluenza A/WSN/33 virusMetabotropic glutamate receptorsAntipsychotic-like effectsPrevention of schizophreniaSpontaneous locomotor activityHigher c-fosEffects of hallucinogensBehavioral changesEgr-2 expressionEtiology of schizophreniaMechanism of actionMaternal infectionInfected mothersMaternal exposureGlutamate agonistsAntipsychotic drugsGlutamate system