2018
HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice
de la Fuente Revenga M, Ibi D, Saunders J, Cuddy T, Ijaz M, Toneatti R, Kurita M, Holloway T, Shen L, Seto J, Dozmorov M, González-Maeso J. HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice. Neuroscience 2018, 388: 102-117. PMID: 30025863, PMCID: PMC6129430, DOI: 10.1016/j.neuroscience.2018.07.010.Peer-Reviewed Original ResearchConceptsHDAC inhibitor SAHAChronic treatmentControl miceFrontal cortexSchizophrenia patientsSynaptic plasticityChronic antipsychotic drug exposureHistone deacetylase 2 (HDAC2) expressionGlutamatergic pyramidal neuronsChronic antipsychotic treatmentAntipsychotic drug exposureAntipsychotic drug actionNew therapeutic approachesConditional knockout micePlasticity-related genesAntipsychotic treatmentPyramidal neuronsDrug exposureAntipsychotic drugsFunctional synapsesHDAC2 functionTherapeutic approachesKnockout micePresynaptic terminalsSAHA treatment
2012
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology 2012, 225: 217-226. PMID: 22842765, PMCID: PMC3552490, DOI: 10.1007/s00213-012-2809-7.Peer-Reviewed Original ResearchConceptsChronic clozapineLysergic acid diethylamideAtypical antipsychotic drug actionHead-twitch behaviorC-fosAntipsychotic-like activityAntipsychotic drug actionTherapeutic-like effectsMouse somatosensory cortexSchizophrenia-like behavioral alterationsEgr-2Egr-1Chronic haloperidolChronic treatmentClozapine administrationDrug therapyOptimal treatmentSomatosensory cortexSingle administrationAntipsychotic drugsMurine modelMouse modelRodent modelsSerotonin 5Behavioral alterations