2022
Paraventricular glia drive circuit function to control metabolism
Varela L, Horvath TL. Paraventricular glia drive circuit function to control metabolism. Cell Metabolism 2022, 34: 1424-1426. PMID: 36198288, DOI: 10.1016/j.cmet.2022.09.012.Peer-Reviewed Original Research
2019
Parallel Paths in PVH Control of Feeding
Varela L, Horvath TL. Parallel Paths in PVH Control of Feeding. Neuron 2019, 102: 514-516. PMID: 31071283, DOI: 10.1016/j.neuron.2019.04.026.Peer-Reviewed Original ResearchMeSH KeywordsEnergy MetabolismFeeding BehaviorHumansHypothalamusObesityParaventricular Hypothalamic Nucleus
2010
Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice
Zheng Q, Zhu J, Shanabrough M, Borok E, Benoit SC, Horvath TL, Clegg DJ, Reizes O. Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice. Neuroscience 2010, 171: 1032-1040. PMID: 20923696, PMCID: PMC2991621, DOI: 10.1016/j.neuroscience.2010.09.060.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAlpha-MSHAnalysis of VarianceAnimalsBody WeightDose-Response Relationship, DrugEatingFeeding BehaviorFood DeprivationGene Expression RegulationMaleMiceMice, KnockoutNeuronsNeuropeptide YParaventricular Hypothalamic NucleusProto-Oncogene Proteins c-fosSignal TransductionSyndecan-3Time FactorsConceptsMelanocortin agonist melanotan IISyndecan-3 null miceParaventricular nucleusBody weightNull miceHypothalamic target neuronsNeuropeptide α-MSHRisk of diabetesC-Fos immunoreactivityHypothalamic paraventricular nucleusBody weight regulationWild-type miceTypes of cancerAnorexigenic αAgRP neuronsHormone neuronsHypothalamic circuitsNeuropeptide YAnorexigenic signalingNeuropeptide responsesCardiovascular diseaseFood intakeTarget neuronsMelanotan IIType miceEarly-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone
Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL, Baram TZ. Early-Life Experience Reduces Excitation to Stress-Responsive Hypothalamic Neurons and Reprograms the Expression of Corticotropin-Releasing Hormone. Journal Of Neuroscience 2010, 30: 703-713. PMID: 20071535, PMCID: PMC2822406, DOI: 10.1523/jneurosci.4214-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornChromatin ImmunoprecipitationCorticotropin-Releasing HormoneExcitatory Amino Acid AntagonistsFemaleGene Expression Regulation, DevelopmentalMaleMaternal DeprivationMicroscopy, Electron, TransmissionNeuronsParaventricular Hypothalamic NucleusPatch-Clamp TechniquesPhysical StimulationPregnancyRatsRats, Sprague-DawleyRepressor ProteinsRNA, MessengerSodium Channel BlockersStress, PsychologicalSynaptic PotentialsTetrodotoxinVesicular Glutamate Transport Protein 2ConceptsCorticotropin-releasing hormoneNeuron-restrictive silencer factorCRH neuronsHypothalamic neuronsCRH expressionEarly life experiencesMiniature excitatory synaptic currentsHypothalamic CRH neuronsExcitatory synaptic currentsCRH gene expressionGlutamate vesicular transporterCRH gene transcriptionTranscriptional repressor neuron-restrictive silencer factorExcitatory innervationExperience-induced neuroplasticityInhibitory synapsesRat pupsExcitatory synapsesSynaptic currentsPersistent suppressionVesicular transportersCognitive functionNeuronsSilencer factorMaternal care
2009
Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway
Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh-I S, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T. Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway. Cell Metabolism 2009, 10: 355-365. PMID: 19883614, DOI: 10.1016/j.cmet.2009.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnorexiaAutocrine CommunicationCalcium-Binding ProteinsDNA-Binding ProteinsLeptinMelanocortinsMiceNerve Tissue ProteinsNeuroendocrine CellsNucleobindinsOxytocinParacrine CommunicationParaventricular Hypothalamic NucleusPro-OpiomelanocortinRatsRats, ZuckerSignal TransductionSolitary NucleusConceptsNucleus tractus solitariusNesfatin-1Oxytocin releaseParacrine/autocrine actionsNesfatin-1 neuronsParaventricular nucleus functionPro-opiomelanocortin (POMC) neuronsZucker fatty ratsOxytocin receptor antagonistOxytocin terminalsPVN neuronsTractus solitariusReceptor antagonistCentral injectionParaventricular nucleusAutocrine actionMelanocortin pathwayNeuronal activityNeural pathwaysPVNAnorexiaNeuronsNucleus functionOxytocinImmunoelectron micrographs
2003
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis. Neuron 2003, 37: 649-661. PMID: 12597862, DOI: 10.1016/s0896-6273(03)00063-1.Peer-Reviewed Original ResearchMeSH KeywordsAgouti-Related ProteinAnimalsCentral Nervous SystemCorticotropin-Releasing HormoneEnergy MetabolismFemaleGhrelinHomeostasisHypothalamusIn Vitro TechniquesIntercellular Signaling Peptides and ProteinsLuminescent ProteinsMiceMice, KnockoutMice, TransgenicNerve NetNeuronsNeuropeptide YOrgan SpecificityParaventricular Hypothalamic NucleusPatch-Clamp TechniquesPeptide HormonesPresynaptic TerminalsPro-OpiomelanocortinProtein BindingProtein BiosynthesisProteinsRatsConceptsCorticotropin-releasing hormoneNeuropeptide YNPY neuronsHypothalamic circuitsGastrointestinal peptide hormone ghrelinEffects of NPYEnergy homeostasisArcuate NPY neuronsRelease of ghrelinExpression of ghrelinMechanism of actionPeptide hormone ghrelinHypothalamic actionOrexigenic peptideHypothalamic nucleiHormone ghrelinParaventricular nucleusProopiomelanocortin (POMC) productsThird ventricleGhrelinPresynaptic terminalsElectrophysiological recordingsNeuronsHypothalamusHomeostasis
1999
Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis.
Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology 1999, 140: 933-40. PMID: 9927326, DOI: 10.1210/endo.140.2.6495.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug SynergismEatingGABA AgonistsGamma-Aminobutyric AcidMaleMuscimolNeuropeptide YParaventricular Hypothalamic NucleusRatsRats, Sprague-DawleyTissue DistributionConceptsGamma-aminobutyric acidStimulation of feedingNeuropeptide YParaventricular nucleusFood intakeArcuate nucleusDose-related fashionEffects of muscimolFeeding responseRat brain sectionsNPY actionNPY terminalsNPY neuronsBrain stemHypothalamic controlReceptor agonistSecond messenger systemsSated ratsAxon terminalsBrain sectionsMagnocellular divisionMuscimolMorphological findingsPharmacological analysisDistinct receptors
1998
Monosynaptic Pathway Between the Arcuate Nucleus Expressing Glial Type II Iodothyronine 5′‐Deiodinase mRNA and the Median Eminence‐Projective TRH Cells of the Rat Paraventricular Nucleus
Diano S, Naftolin F, Goglia F, Csernus V, Horvath T. Monosynaptic Pathway Between the Arcuate Nucleus Expressing Glial Type II Iodothyronine 5′‐Deiodinase mRNA and the Median Eminence‐Projective TRH Cells of the Rat Paraventricular Nucleus. Journal Of Neuroendocrinology 1998, 10: 731-742. PMID: 9792325, DOI: 10.1046/j.1365-2826.1998.00204.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArcuate Nucleus of HypothalamusFemaleFluorescent DyesImmunohistochemistryIn Situ HybridizationIodide PeroxidaseIsoenzymesMaleMedian EminenceNeural PathwaysNeurogliaParaventricular Hypothalamic NucleusPhytohemagglutininsRatsRats, Sprague-DawleyRNA, MessengerStilbamidinesThyrotropin-Releasing HormoneSegregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone
Diano S, Naftolin F, Goglia F, Horvath T. Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone. Peptides 1998, 75: 117-126. PMID: 9802401, DOI: 10.1016/s0167-0115(98)00060-3.Peer-Reviewed Original ResearchConceptsParvicellular paraventricular nucleusMedian forebrain bundleProximal dendritesTRH neuronsDistal dendritesCell bodiesTRH cellsNPY inputAsymmetric synapsesCatecholaminergic inputsTyrosine hydroxylaseDendritic spinesInvolvement of NPYNumber of NPYThyrotropin-releasing hormone (TRH) mRNATH-immunoreactive fibersThyroid feedbackThyrotropin-releasing hormoneFood deprivationLight microscopic examinationTRH immunoreactive cellsNPY fibersNPY releaseHypothalamic NPYCatecholaminergic neurons
1996
Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus
Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 1996, 137: 3069-3077. PMID: 8770933, DOI: 10.1210/endo.137.7.8770933.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsArcuate Nucleus of HypothalamusAxonsCerebral VentriclesColchicineDendritesEstradiolEstrusFemaleGalaninHypothalamusHypothalamus, AnteriorImmunoenzyme TechniquesImmunohistochemistryLuteinizing HormoneMicroscopy, ImmunoelectronNeuronsNeuropeptide YOvariectomyParaventricular Hypothalamic NucleusPreoptic AreaProgesteroneRatsRats, Sprague-DawleySignal TransductionSubstance PSupraoptic NucleusConceptsNeuropeptide YMedial preoptic areaLH releaseGAL neuronsArcuate nucleusIntraventricular injectionParaventricular nucleusPreoptic areaSupraoptic nucleusSynaptic connectionsBasal LH releaseNPY-immunoreactive axonsPituitary hormone secretionPituitary gonadotropin releaseRelease of gonadotropinsMicroscopic examinationHypothalamic peptidergic systemsPeroxidase-antiperoxidase techniqueAvidin-biotin peroxidaseLight microscopic examinationMechanism of actionDiaminobenzidine reactionGAL releaseNPY inputNPY administration