2016
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nature Neuroscience 2016, 20: 176-188. PMID: 27991900, PMCID: PMC7615022, DOI: 10.1038/nn.4462.Peer-Reviewed Original Research
2009
Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge
Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens Regulate Posttranslational Modification of Neural Cell Adhesion Molecule during the Estrogen-Induced Gonadotropin Surge. Endocrinology 2009, 150: 2783-2790. PMID: 19282389, DOI: 10.1210/en.2008-0927.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEstradiolEstrogensEstrous CycleFemaleGonadotropinsMiceMice, Inbred C57BLMidline Thalamic NucleiModels, AnimalNeural Cell Adhesion Molecule L1Neural Cell Adhesion MoleculesNeuronal PlasticityProtein IsoformsProtein Processing, Post-TranslationalRNA, MessengerSialic AcidsSialyltransferasesSynapsesConceptsNeural cell adhesion moleculePeriventricular areaIR-PSAPerineural spacePSA-NCAMCell adhesion moleculeAdhesion moleculesPSA-NCAM stainingExtent of stainingSialyltransferase mRNA levelsGonadotropin surgeNCAM stainingPreovulatory gonadotropinSynaptic plasticityProestrous afternoonEstrogenWestern blotProestrusIndividual neuronsRT-PCRMetestrusMRNA levelsHypothalamus tissueStainingSialyltransferase mRNA
1997
Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine.
Horvath T. Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine. Endocrinology 1997, 138: 1312-20. PMID: 9048641, DOI: 10.1210/endo.138.3.4976.Peer-Reviewed Original ResearchConceptsPituitary hormone secretionVasculosum laminae terminalisSuprachiasmatic nucleusHormone secretionNeuroendocrine cellsPreoptic areaLamina terminalisDopamine cellsMedian eminenceAnterior pituitary hormone secretionMedial preoptic areaDiffuse cytoplasmic labelingPhaseolus vulgaris leukoagglutininFluorogold labelingPeriventricular areaArcuate nucleusHypothalamic sitesIP administrationVentromedial nucleusAnterior hypothalamusAnterograde tracerAxon terminalsPeriventricular regionElectron microscopic examinationTyrosine hydroxylase
1995
Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase
Herbison A, Horvath T, Naftolin F, Leranth C. Distribution of Estrogen Receptor-Immunoreactive Cells in Monkey Hypothalamus: Relationship to Neurones Containing Luteinizing Hormone-Releasing Hormone and Tyrosine Hydroxylase. Neuroendocrinology 1995, 61: 1-10. PMID: 7731492, DOI: 10.1159/000126810.Peer-Reviewed Original ResearchConceptsER-immunoreactive cellsHormone-releasing hormoneER immunoreactivityMonkey hypothalamusTyrosine hydroxylaseDouble-labeling experimentsProgesterone receptorDopaminergic neuronesLHRH neuronesEstrogen receptor-immunoreactive cellsReceptor-immunoreactive cellsPituitary hormone secretionSpecific hypothalamic nucleiTH-immunoreactive cellsPR-containing cellsDopamine-containing neuronesHypothalamic dopaminergic neuronesAfrican green monkeysLHRH neuronsPeriventricular areaSteroid statusArcuate nucleusHormone secretionHypothalamic nucleiPrimate hypothalamus
1993
Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study
Horvath TL, Shanabrough M, Naftolin F, Leranth C. Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study. Endocrinology 1993, 133: 405-414. PMID: 8100520, DOI: 10.1210/endo.133.1.8100520.Peer-Reviewed Original ResearchConceptsTyrosine hydroxylase-immunoreactive neuronsHydroxylase-immunoreactive neuronsProgesterone receptorSynaptic contactsAxon terminalsDopamine cellsTyrosine hydroxylase-immunopositive cellsHypophyseal hormone secretionEffects of NPYDorsomedial hypothalamic nucleusCoronal vibratome sectionsNuclear progesterone receptorPR-containing cellsAfrican green monkeysDiaminobenzidine reactionNPY axonsPeriventricular areaOVX animalsHormone secretionMonkey hypothalamusAnterior hypothalamusHypothalamic nucleiDopamine neuronsPRL releaseEstrogenLuteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas
Horvath T, Naftolin F, Leranth C. Luteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas. Journal Of Neuroendocrinology 1993, 5: 71-79. PMID: 8097941, DOI: 10.1111/j.1365-2826.1993.tb00365.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCerebral VentriclesColchicineDopamineFemaleGamma-Aminobutyric AcidGlutamate DecarboxylaseGonadotropin-Releasing HormoneImmunohistochemistryMicroscopy, ElectronNeuronsOxidopaminePhytohemagglutininsPreoptic AreaRatsRats, Sprague-DawleySynapsesTissue FixationTyrosine 3-MonooxygenaseConceptsHormone-releasing hormoneMedial preoptic areaGlutamic acid decarboxylasePhaseolus vulgaris leucoagglutininZona incertaPreoptic areaTyrosine hydroxylaseGlutamic acid decarboxylase-immunoreactive neuronsDopamine axonsTyrosine hydroxylase-immunoreactive boutonsAcid decarboxylaseGamma-aminobutyric acid (GABA) neuronsRat medial preoptic areaAnterior periventricular areaDesipramine-pretreated ratsDopamine axon terminalsAnteroventral periventricular nucleusCell of originEarly morphological signsDopaminergic connectionsGABA neuronsGABA cellsPeriventricular areaAcute degenerationSynaptic contacts
1992
Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study
Horvath TL, Naftolin F, Leranth C. Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology 1992, 131: 1547-1555. PMID: 1354605, DOI: 10.1210/endo.131.3.1354605.Peer-Reviewed Original ResearchConceptsDopamine neuronsZona incertaDopamine cellsSynaptic connectionsCell bodiesDouble immunostaining experimentsHypophyseal hormone secretionHypothalamic dopaminergic systemFemale rat brainHypothalamic dopaminergic neuronsDorsomedial hypothalamic nucleusDopamine cell bodiesReceptor-containing cellsDouble immunostaining studiesLight microscopic examinationPutative synaptic connectionsLH releaseDopamine innervationImmunoreactive boutonsPeriventricular areaDopaminergic neuronsPRL secretionSynaptic contactsArcuate nucleusHormone secretionPresence of calbindin and lack of parvalbumin in progesterone receptor-containing neurons of the monkey mediobasal hypothalamus
Horvath TL, Leranth C, Naftolin* F. Presence of calbindin and lack of parvalbumin in progesterone receptor-containing neurons of the monkey mediobasal hypothalamus. Neuroscience 1992, 50: 309-314. PMID: 1436493, DOI: 10.1016/0306-4522(92)90425-2.Peer-Reviewed Original ResearchConceptsProgesterone receptor-containing neuronsReceptor-containing neuronsReceptor-containing cellsCalbindin-immunoreactive neuronsProgesterone receptorAsymmetric synaptic contactsPresence of calbindinCentral nervous systemAfrican green monkeysLight microscopic resultsGABA neuronsGABAergic neuronsPeriventricular areaSynaptic contactsMonkey hypothalamusPostsynaptic targetsExcitatory fibresInfundibular nucleusMediobasal hypothalamusCalcium-binding proteinsNervous systemCalbindin cellsCalbindinNeuronsParvalbumin content