2022
The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study
Mahmud N, Serper M, Taddei TH, Kaplan DE. The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Gastroenterology 2022, 163: 257-269.e6. PMID: 35398042, PMCID: PMC10020994, DOI: 10.1053/j.gastro.2022.03.052.Peer-Reviewed Original ResearchConceptsLiver-related mortalityPPI exposureGastrointestinal bleedingCause mortalityProton pump inhibitor exposurePrior gastrointestinal bleedingTime-updated variablesCause-specific mortality analysesLarge national cohortVeterans Health AdministrationRisk of infectionCardiovascular comorbiditiesPPI useCohort studyStatin exposureCox regressionRetrospective studyAdverse outcomesAppropriate indicationsNational cohortInhibitor exposureSevere infectionsCirrhosis diagnosisAdditional adjustmentAdjusted model
2021
The Predictive Role of Model for End‐Stage Liver Disease–Lactate and Lactate Clearance for In‐Hospital Mortality Among a National Cirrhosis Cohort
Mahmud N, Asrani SK, Kaplan DE, Ogola GO, Taddei TH, Kamath PS, Serper M. The Predictive Role of Model for End‐Stage Liver Disease–Lactate and Lactate Clearance for In‐Hospital Mortality Among a National Cirrhosis Cohort. Liver Transplantation 2021, 27: 177-189. PMID: 33025731, PMCID: PMC7880877, DOI: 10.1002/lt.25913.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseHospital mortalityLactate clearanceCirrhosis hospitalizationsMELD-NaLiver diseaseDay 1Predictive roleRetrospective cohort studyIn-Hospital MortalityRisk-stratify patientsVeterans Health AdministrationCirrhosis cohortMELD categoriesGastrointestinal bleedingCohort studyClinical dataLimited cohortStratified analysisLactate levelsHospitalizationHealth AdministrationMELDClinical toolMortality
2019
Quality Measures, All‐Cause Mortality, and Health Care Use in a National Cohort of Veterans With Cirrhosis
Serper M, Kaplan DE, Shults J, Reese PP, Beste LA, Taddei TH, Werner RM. Quality Measures, All‐Cause Mortality, and Health Care Use in a National Cohort of Veterans With Cirrhosis. Hepatology 2019, 70: 2062-2074. PMID: 31107967, PMCID: PMC6864236, DOI: 10.1002/hep.30779.Peer-Reviewed Original ResearchConceptsHealth care useHepatocellular carcinoma surveillanceCause mortalityCare useVariceal surveillanceQuality improvement effortsPostdischarge careNational cohortSpecialty careOutpatient accessFuture quality improvement effortsLiver disease cohortUpper gastrointestinal bleedingLarge national cohortGastrointestinal bleedingMean followAdjusted analysisHigh morbidityRetrospective studyDomains of accessVeteran outcomesStandardized quality measuresInpatient careDisease cohortHigh adherence
2013
Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence
Bosch J, Groszmann R, Iwakiri Y, Taddei T. Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence. Hepatology 2013, 57: 1665-1667. PMID: 23359118, DOI: 10.1002/hep.26279.Peer-Reviewed Original ResearchCarvedilol groupSevere adverse eventsVariceal bleedingAdverse eventsVariceal rebleedingRecurrent bleedingI groupControl of acute esophageal variceal bleedingPrevention of gastroesophageal variceal rebleedingPreventing recurrent variceal bleedingAcute esophageal variceal bleedingDecrease portal pressureRecurrent upper gastrointestinal bleedingRecurrent variceal bleedingEsophageal variceal bleedingUpper gastrointestinal bleedingMedian followEsophageal varicesGastric varicesPortal pressureGastrointestinal bleedingIsosorbide mononitrateBleedingCarvedilolPatients