Effects of the Homeodomain Gene Pitx2 on Self-Renewal of Hematopoietic Stem Cells.
Zhang H, Rogulina S, Chen W, Degar B, Forget B. Effects of the Homeodomain Gene Pitx2 on Self-Renewal of Hematopoietic Stem Cells. Blood 2007, 110: 95. DOI: 10.1182/blood.v110.11.95.95.Peer-Reviewed Original ResearchHematopoietic stem cellsWild-type cellsHematopoietic stem/progenitor cellsStem/progenitor cellsBone marrow cellsGene Pitx2Integration sitesLong-term reconstitutionType cellsMurine hematopoietic stem/progenitor cellsMurine bone marrow cellsStem cellsProgenitor cellsGM coloniesMarrow cellsRetroviral integration sitesMulti-lineage hematopoiesisHomeodomain genesSelf-renewal capacityColony-forming unit assaysDownstream targetsSelf-RenewalPITX2 geneGFP expressionNull cells