2008
Acute Myeloid Leukemia in Mice Associated with Retrovirally-Mediated Overexpression of HOXB4
Zhang H, Chen W, Rogulina S, Lee H, Forget B. Acute Myeloid Leukemia in Mice Associated with Retrovirally-Mediated Overexpression of HOXB4. Blood 2008, 112: 4484. DOI: 10.1182/blood.v112.11.4484.4484.Peer-Reviewed Original ResearchRetroviral integration sitesOverexpression of HOXB4Hematopoietic stem cellsIntegration sitesBone marrow cellsIntron 1Ability of HSCsIntrons of genesMurine bone marrow cellsEffect of knockdownNorthern blot analysisStem cell markers c-KitControl bone marrow cellsN-ras genePRDM16 geneLMO2 geneKb upstreamMRNA accumulationHOXB4Leukemic bone marrow cellsGFP retrovirusCombinatorial fashionGenesLeukemic cellsIntron 2
2007
Effects of the Homeodomain Gene Pitx2 on Self-Renewal of Hematopoietic Stem Cells.
Zhang H, Rogulina S, Chen W, Degar B, Forget B. Effects of the Homeodomain Gene Pitx2 on Self-Renewal of Hematopoietic Stem Cells. Blood 2007, 110: 95. DOI: 10.1182/blood.v110.11.95.95.Peer-Reviewed Original ResearchHematopoietic stem cellsWild-type cellsHematopoietic stem/progenitor cellsStem/progenitor cellsBone marrow cellsGene Pitx2Integration sitesLong-term reconstitutionType cellsMurine hematopoietic stem/progenitor cellsMurine bone marrow cellsStem cellsProgenitor cellsGM coloniesMarrow cellsRetroviral integration sitesMulti-lineage hematopoiesisHomeodomain genesSelf-renewal capacityColony-forming unit assaysDownstream targetsSelf-RenewalPITX2 geneGFP expressionNull cells