2023
Nucleolar structure connects with global nuclear organization.
Wang C, Ma H, Baserga S, Pederson T, Huang S. Nucleolar structure connects with global nuclear organization. Molecular Biology Of The Cell 2023, 34: ar114. PMID: 37610836, PMCID: PMC10846622, DOI: 10.1091/mbc.e23-02-0062.Peer-Reviewed Original ResearchConceptsNucleolar structureGenomic lociNuclear domainsSpecific genomic lociGlobal nuclear organizationRNA processing factorsRNA polymerase ICajal bodiesNuclear organizationRibosome synthesisNuclear bodiesKnockdown cellsPerinucleolar compartmentPolymerase IIntranuclear locationHeLa cellsNucleolar segregationSpatial organizationNucleoliLociUtp4CellsRPA194SegregationCompositional changes
2022
Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing
McCool M, Buhagiar A, Bryant C, Ogawa L, Abriola L, Surovtseva Y, Baserga S. Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing. RNA 2022, 29: rna.079149.122. PMID: 36323459, PMCID: PMC9808572, DOI: 10.1261/rna.079149.122.Peer-Reviewed Original ResearchRRNA transcriptionRRNA processingRibosomal subunit biogenesisRNA polymerase IRibosome biosynthesisSubunit biogenesisRibosome biogenesisRibosome assemblyAssembly factorsTranscription controlBiogenesis factorsRRNA productionSteady-state levelsRNA transcriptionPolymerase IComplex membersHuman cellsProtein synthesisP53 stabilizationTranscriptionEssential processBiogenesisCell proliferationDual roleRegulatory details
2005
Autoantibody Recognition of Macromolecular Structures and Their Subunits
Champion E, Baserga S. Autoantibody Recognition of Macromolecular Structures and Their Subunits. 2005, 379-417. DOI: 10.1002/3527607854.ch17.Peer-Reviewed Original ResearchSm monoclonal antibodyRNA polymerase IBox C/D small nucleolar RNAsPre-mRNA splicingRNase MRPSmall nucleolar RNAsRNase PPolymerase IU3 snoRNASubcellular localizationMolecular markersProtein componentsNucleolar RNAsHuman exosomeNew functionsPolymyositis-scleroderma overlap syndromeCurrent understandingSnRNPsSnoRNAsSplicingFibrillarinNucleolarMonoclonal antibodiesExosomesHUBF