2021
Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine
Trentelman JJA, Tomás-Cortázar J, Knorr S, Barriales D, Hajdusek O, Sima R, Ersoz JI, Narasimhan S, Fikrig E, Nijhof AM, Anguita J, Hovius JW. Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine. Scientific Reports 2021, 11: 15745. PMID: 34344917, PMCID: PMC8333314, DOI: 10.1038/s41598-021-92538-9.Peer-Reviewed Original ResearchConceptsTick salivary gland proteinsLyme borreliosisVaccination studiesTick biteTick-borne encephalitis virusB. burgdorferi transmissionMultiple tick bitesYeast surface display libraryHuman infectious diseasesImmunization of rabbitsVaccination platformAnti-tick effectsAnti-tick vaccinesEncephalitis virusImmunodominant antigensInfectious diseasesNon-natural hostsTick immunityTick feedingImmunityBorreliosisBiteVaccineAntigenHuman serum
1999
Experimental approaches to the development of a recombinant hookworm vaccine
Hotez P, Ghosh K, Huwdon J, Narasimhan S, Jones B, Shuhua X, Sen L, Bin Z, Haechou X, Hainan R, Heng W, Koski R. Experimental approaches to the development of a recombinant hookworm vaccine. Immunological Reviews 1999, 171: 163-171. PMID: 10582170, DOI: 10.1111/j.1600-065x.1999.tb01347.x.Peer-Reviewed Original ResearchConceptsHookworm infectionHeavy hookworm infectionMajor parasitic causeHookworm antigensSerologic correlatesVaccine protectionChallenge infectionHookworm burdenHookworm vaccineParasitic causesEndemic areasHuman infectionsInfectionLaboratory animalsVaccineAlum precipitateMorbidityRecombinant polypeptidesHookwormAntigenDiseaseMiceImmunityAntibodies