2021
Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid
Peterson M, Cherukuri V, Paulson J, Ssentongo P, Kulkarni A, Warf B, Monga V, Schiff S. Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid. Journal Of Neurosurgery Pediatrics 2021, 28: 458-468. PMID: 34243147, PMCID: PMC8594737, DOI: 10.3171/2021.2.peds201006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsAnalysis of VarianceAnthropometryBody WeightBrainCerebrospinal FluidChildChild DevelopmentChild, PreschoolCohort StudiesFemaleFunctional LateralityHumansHydrocephalusInfantInfant, NewbornMagnetic Resonance ImagingMaleOrgan SizePopulationReference StandardsSex CharacteristicsConceptsBrain growthBrain volumeFluid accumulationRatio of brainHealthy pediatric subjectsTotal brain volumeAge 18 yearsYears of ageRegional brain volumesNormal brain growthAge-dependent relationshipCSF accumulationPediatric subjectsChildhood diseasesCerebrospinal fluidCSF volumeCongenital disorderVolume trajectoriesEarly childhoodNormative growth curvesNumerous conditionsSexMagnetic resonanceBrain sizeGlobal, regional and national epidemiology and prevalence of child stunting, wasting and underweight in low- and middle-income countries, 2006–2018
Ssentongo P, Ssentongo A, Ba D, Ericson J, Na M, Gao X, Fronterre C, Chinchilli V, Schiff S. Global, regional and national epidemiology and prevalence of child stunting, wasting and underweight in low- and middle-income countries, 2006–2018. Scientific Reports 2021, 11: 5204. PMID: 33664313, PMCID: PMC7933191, DOI: 10.1038/s41598-021-84302-w.Peer-Reviewed Original Research
2018
Normative human brain volume growth.
Peterson M, Warf B, Schiff S. Normative human brain volume growth. Journal Of Neurosurgery Pediatrics 2018, 21: 478-485. PMID: 29498607, PMCID: PMC6212293, DOI: 10.3171/2017.10.peds17141.Peer-Reviewed Original ResearchConceptsStatistical measuresPower lawNonlinear least-squares regression algorithmGood statistical resultsLeast squares regression algorithmCurve fitCandidate modelsCorresponding statisticsAppropriate statistical measuresFit parametersStatistical resultsRegression algorithmWeibull fitWeibull modelNormative MRI dataPotential modelFitVolume growthGompertz modelBest modelModelModel curve fitWeibullLawStatistics
2014
Volumetric brain analysis in neurosurgery: Part 1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT images.
Mandell J, Langelaan J, Webb A, Schiff S. Volumetric brain analysis in neurosurgery: Part 1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT images. Journal Of Neurosurgery Pediatrics 2014, 15: 113-24. PMID: 25431902, DOI: 10.3171/2014.9.peds12426.Peer-Reviewed Original ResearchConceptsEdge trackerParticle filterGround vehicle navigationBrain image analysisCT imagesMRI data setsImage segmentationSegmentation algorithmAutonomous airVehicle navigationAccurate edgesNovel algorithmManual segmentationSegmentationMR imagesBrain dataVolumetric brain analysisData setsImage analysisSemiautomatic methodImagesModality independenceHistorical dataAlgorithmMRI dataVolumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus.
Mandell J, Kulkarni A, Warf B, Schiff S. Volumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus. Journal Of Neurosurgery Pediatrics 2014, 15: 125-32. PMID: 25431901, DOI: 10.3171/2014.9.peds12427.Peer-Reviewed Original ResearchConceptsFrontal-occipital horn ratioNeurocognitive outcomesBrain volumeCSF volumeFluid volumePediatric patientsBrain developmentEvaluation of hydrocephalusGoal of treatmentSmaller brain volumesLower cognitive outcomesPoor neurocognitive outcomesNormal brain developmentLarge fluid volumesHealthy brain developmentVolumetric brain analysisSurgical treatmentVentricular sizeHydrocephalic patientsCT scanHydrocephalusPatientsBayley ScalesBrain growthFine motorVolumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy.
Mandell J, Hill K, Nguyen D, Moser K, Harbaugh R, McInerney J, Nsubuga B, Mugamba J, Johnson D, Warf B, Boling W, Webb A, Schiff S. Volumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy. Journal Of Neurosurgery Pediatrics 2014, 15: 133-43. PMID: 25431899, DOI: 10.3171/2014.9.peds12428.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnterior Temporal LobectomyBrainCerebrospinal FluidChildChild, PreschoolCognitionCone-Beam Computed TomographyEpilepsy, Temporal LobeFemaleFrontal LobeHumansHydrocephalusInfantMagnetic Resonance ImagingMaleNeurosurgical ProceduresOccipital LobeOrgan SizePredictive Value of TestsSeizuresTreatment OutcomeUgandaConceptsTemporal lobe volumeMesial temporal sclerosisTemporal lobe epilepsyTemporal lobe resectionSeizure outcomeTemporal lobeVolumetric CT analysisBrain volumeLobe volumeSeizure controlStructural MRILobe resectionEngel class Ia outcomeClass Ia outcomeSelection of patientsCT volumetric analysisPreoperative CT scanSmaller brain volumesSmaller temporal lobeCURE Children's HospitalIncomplete seizure controlNormalized brain volumeWhole brain volumeCT analysisTemporal lobe structures
2012
Rainfall drives hydrocephalus in East Africa.
Schiff S, Ranjeva S, Sauer T, Warf B. Rainfall drives hydrocephalus in East Africa. Journal Of Neurosurgery Pediatrics 2012, 10: 161-7. PMID: 22768966, DOI: 10.3171/2012.5.peds11557.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, EasternAlgorithmsChildChild, PreschoolHumansHydrocephalusInfantInfectionsMaleRainRisk FactorsSeasonsTropical ClimateUganda
2011
Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants.
Warf B, Dagi A, Kaaya B, Schiff S. Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants. Journal Of Neurosurgery Pediatrics 2011, 8: 502-8. PMID: 22044377, DOI: 10.3171/2011.8.peds11221.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusFive-year survivalShunt placementPrimary brain injuryWorse functional outcomeKaplan-Meier methodLong-term outcomesLog-rank testOutcome of treatmentEndoscopic third ventriculostomyTreatment selection biasPublic health measuresOne-thirdUgandan infantsWorst sequelaeOperative mortalityNeonatal infectionFunctional outcomeThird ventriculostomyBrain injuryPrimary treatmentCommon causeInfant hydrocephalusSurvival advantageOriginal infection
2000
Long-Term Follow-Up Data from the Shunt Design Trial
Kestle J, Drake J, Milner R, Sainte-Rose C, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Long-Term Follow-Up Data from the Shunt Design Trial. Pediatric Neurosurgery 2000, 33: 230-236. PMID: 11155058, DOI: 10.1159/000055960.Peer-Reviewed Original ResearchConceptsFirst shunt failureShunt failureDifferential pressure valvesOverall shunt survivalShunt Design TrialShunt failure ratesLate complicationsShunt surgeryShunt survivalInitial treatmentTerm followShunt obstructionDelta valvesHydrocephalic childrenOriginal trialPediatric hydrocephalusSurvival advantagePatient statusPatientsTrialsDesign trialSignificant differencesObstructionOverdrainageInfection
1998
Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus.
Drake J, Kestle J, Milner R, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurgery 1998, 43: 294-303; discussion 303-5. PMID: 9696082, DOI: 10.1097/00006123-199808000-00068.Peer-Reviewed Original ResearchConceptsShunt obstructionDifferential pressure valvesShunt failurePediatric hydrocephalusCerebrospinal fluid shunt failuresCerebrospinal fluid shunt insertionTreatment failure rateShunt failure ratesOrbis-Sigma valvePediatric neurosurgical centersUpright positionCerebrospinal fluid shuntsIndependent case reviewShunt insertionCerebral ventricleDelta valvesHydrocephalic childrenFailure rateNeurosurgical centersOutcome eventsCase reviewPatientsObstructionShunt valveInfection
1995
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children
Heyes M, Saito K, Milstien S, Schiff S. Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. Journal Of The Neurological Sciences 1995, 133: 112-118. PMID: 8583213, DOI: 10.1016/0022-510x(95)00164-w.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial InfectionsBiomarkersBiopterinCentral Nervous System DiseasesCentral Nervous System NeoplasmsCerebral HemorrhageChildChild, PreschoolFemaleGuanosine TriphosphateHumansHydrocephalusInfantInfant, NewbornInterleukin-6KynurenineMaleNeopterinQuinolinic AcidTryptophan OxygenaseTumor Necrosis Factor-alphaConceptsCentral nervous systemQuinolinic acidImmune activationKynurenine pathwayNervous systemBacterial infectionsLevels of QUINCentral nervous system infectionCSF QUIN levelsNervous system infectionCytokine tumor necrosisCNS inflammationNeurological deficitsSystem infectionNeurologic dysfunctionCSF levelsQUIN levelsQUIN concentrationsInterleukin-6Tumor necrosisCerebrospinal fluidNeurotoxic metabolitesSensitive markerMacrophage activationPatients
1994
Time-related patterns of ventricular shunt failure
Kast J, Duong D, Nowzari F, Chadduck W, Schiff S. Time-related patterns of ventricular shunt failure. Child's Nervous System 1994, 10: 524-528. PMID: 7882375, DOI: 10.1007/bf00335075.Peer-Reviewed Original ResearchConceptsShunt failureVentricular shunt failureVentriculoperitoneal shunt failureAge of patientsCatheter placement techniqueVentricular catheter placementNovel valve systemDistal failureDistal malfunctionProximal malfunctionConsecutive patientsProximal obstructionShunt placementCatheter placementPrimary etiologyShunt revisionShunt malfunctionSite of failureTime-related patternOverall seriesProximal failureCommon causeOutcome studiesHigh incidencePatientsSeizure control following tumor surgery for childhood cortical low-grade gliomas.
Packer R, Sutton L, Patel K, Duhaime A, Schiff S, Weinstein S, Gaillard W, Conry J, Schut L. Seizure control following tumor surgery for childhood cortical low-grade gliomas. Journal Of Neurosurgery 1994, 80: 998-1003. PMID: 8189281, DOI: 10.3171/jns.1994.80.6.0998.Peer-Reviewed Original ResearchConceptsSeizure controlPoor seizure controlLow-grade gliomasElectrocortical mappingSeizure focusTumor resectionTumor surgeryEEG monitoringLong-term seizure controlLow-grade glial tumorsPartial tumor resectionGood seizure controlHistory of seizuresExtensive tumor resectionLow-grade neoplasmsMajority of childrenCortical tumorsSeizure outcomeSurgical resectionPartial resectionTumor locationTumor removalGlial tumorsHigh riskResection
1993
Reflex variability in selective dorsal rhizotomy.
Weiss I, Schiff S. Reflex variability in selective dorsal rhizotomy. Journal Of Neurosurgery 1993, 79: 346-53. PMID: 8360730, DOI: 10.3171/jns.1993.79.3.0346.Peer-Reviewed Original Research