2024
Paediatric hydrocephalus
Kahle K, Klinge P, Koschnitzky J, Kulkarni A, MacAulay N, Robinson S, Schiff S, Strahle J. Paediatric hydrocephalus. Nature Reviews Disease Primers 2024, 10: 35. PMID: 38755194, DOI: 10.1038/s41572-024-00519-9.Peer-Reviewed Original ResearchConceptsSymptoms of elevated intracranial pressureCerebrospinal fluidCentral nervous system infectionChoroid plexus cauterizationEndoscopic third ventriculostomyNervous system infectionNonsurgical treatment strategiesElevated intracranial pressureLong-term outcomesNeural tube defectsCSF-brain interfaceFetal hydrocephalusUtero treatmentAcquired hydrocephalusCSF secretionSurgical closureCSF shuntingHead circumferenceThird ventriculostomyCongenital hydrocephalusAssociated with blockageGene mutationsCerebral ventricleTreatment strategiesCSF pathways
2023
Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study
Morton S, Hehnly C, Burgoine K, Ssentongo P, Ericson J, Kumar M, Hagmann C, Fronterre C, Smith J, Movassagh M, Streck N, Bebell L, Bazira J, Kumbakumba E, Bajunirwe F, Mulondo R, Mbabazi-Kabachelor E, Nsubuga B, Natukwatsa D, Nalule E, Magombe J, Erickson T, Ngonzi J, Ochora M, Olupot-Olupot P, Onen J, Ssenyonga P, Mugamba J, Warf B, Kulkarni A, Lane J, Whalen A, Zhang L, Sheldon K, Meier F, Kiwanuka J, Broach J, Paulson J, Schiff S. Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study. The Lancet Microbe 2023, 4: e601-e611. PMID: 37348522, PMCID: PMC10529524, DOI: 10.1016/s2666-5247(23)00106-4.Peer-Reviewed Original ResearchConceptsMother-newborn pairsPostinfectious hydrocephalusCerebrospinal fluidNeonatal sepsisSpp infectionUgandan infantsMaternal bloodObservational case-control studyHospital OfficeInfant's cerebrospinal fluidBurden of morbidityCase-control studyRoute of infectionSubset of participantsMaternal feverCranial ultrasoundNeonatal infectionSepsis cohortOptimise treatmentTransplacental transmissionCord bloodObservational studyPlacental samplesSepsisHydrocephalusInfection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach
Yu M, Peterson M, Cherukuri V, Hehnly C, Mbabazi-Kabachelor E, Mulondo R, Kaaya B, Broach J, Schiff S, Monga V. Infection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach. Journal Of Neural Engineering 2023, 20: 10.1088/1741-2552/acd9ee. PMID: 37253355, PMCID: PMC11099590, DOI: 10.1088/1741-2552/acd9ee.Peer-Reviewed Original Research
2021
Assessing the utility of low resolution brain imaging: treatment of infant hydrocephalus
Harper JR, Cherukuri V, O’Reilly T, Yu M, Mbabazi-Kabachelor E, Mulando R, Sheth KN, Webb AG, Warf BC, Kulkarni AV, Monga V, Schiff SJ. Assessing the utility of low resolution brain imaging: treatment of infant hydrocephalus. NeuroImage Clinical 2021, 32: 102896. PMID: 34911199, PMCID: PMC8646178, DOI: 10.1016/j.nicl.2021.102896.Peer-Reviewed Original ResearchConceptsDeep learning enhancementLow-quality imagesDeep learningQuality imagesDeep learning algorithmsEnhanced imageRole of machineLearning enhancementImage qualityLearning algorithmAcceptable image qualityReconstruction errorImage resolutionImagesAlgorithmCT imagesLearningCT counterpartsNoise ratioTreatment planningPlanningNew standardStructural errorsExperienced pediatric neurosurgeonsMachineNormal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid
Peterson M, Cherukuri V, Paulson J, Ssentongo P, Kulkarni A, Warf B, Monga V, Schiff S. Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid. Journal Of Neurosurgery Pediatrics 2021, 28: 458-468. PMID: 34243147, PMCID: PMC8594737, DOI: 10.3171/2021.2.peds201006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsAnalysis of VarianceAnthropometryBody WeightBrainCerebrospinal FluidChildChild DevelopmentChild, PreschoolCohort StudiesFemaleFunctional LateralityHumansHydrocephalusInfantInfant, NewbornMagnetic Resonance ImagingMaleOrgan SizePopulationReference StandardsSex CharacteristicsConceptsBrain growthBrain volumeFluid accumulationRatio of brainHealthy pediatric subjectsTotal brain volumeAge 18 yearsYears of ageRegional brain volumesNormal brain growthAge-dependent relationshipCSF accumulationPediatric subjectsChildhood diseasesCerebrospinal fluidCSF volumeCongenital disorderVolume trajectoriesEarly childhoodNormative growth curvesNumerous conditionsSexMagnetic resonanceBrain size
2020
Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants
Paulson J, Williams B, Hehnly C, Mishra N, Sinnar S, Zhang L, Ssentongo P, Mbabazi-Kabachelor E, Wijetunge D, von Bredow B, Mulondo R, Kiwanuka J, Bajunirwe F, Bazira J, Bebell L, Burgoine K, Couto-Rodriguez M, Ericson J, Erickson T, Ferrari M, Gladstone M, Guo C, Haran M, Hornig M, Isaacs A, Kaaya B, Kangere S, Kulkarni A, Kumbakumba E, Li X, Limbrick D, Magombe J, Morton S, Mugamba J, Ng J, Olupot-Olupot P, Onen J, Peterson M, Roy F, Sheldon K, Townsend R, Weeks A, Whalen A, Quackenbush J, Ssenyonga P, Galperin M, Almeida M, Atkins H, Warf B, Lipkin W, Broach J, Schiff S. Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants. Science Translational Medicine 2020, 12 PMID: 32998967, PMCID: PMC7774825, DOI: 10.1126/scitranslmed.aba0565.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusCSF samplesPIH casesPotential causative organismsCerebrospinal fluid accumulationCytomegalovirus coinfectionUgandan infantsNeonatal sepsisSurgical palliationNeonatal infectionInfant casesOptimal treatmentInfant cohortCommon causeCausative organismPediatric hydrocephalusFluid accumulationHydrocephalusAnaerobic bacterial isolatesControl casesInfectionFacultative anaerobic bacterial isolatesInfantsParasitic DNADisease
2018
Normative human brain volume growth.
Peterson M, Warf B, Schiff S. Normative human brain volume growth. Journal Of Neurosurgery Pediatrics 2018, 21: 478-485. PMID: 29498607, PMCID: PMC6212293, DOI: 10.3171/2017.10.peds17141.Peer-Reviewed Original ResearchConceptsStatistical measuresPower lawNonlinear least-squares regression algorithmGood statistical resultsLeast squares regression algorithmCurve fitCandidate modelsCorresponding statisticsAppropriate statistical measuresFit parametersStatistical resultsRegression algorithmWeibull fitWeibull modelNormative MRI dataPotential modelFitVolume growthGompertz modelBest modelModelModel curve fitWeibullLawStatistics
2014
Volumetric brain analysis in neurosurgery: Part 1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT images.
Mandell J, Langelaan J, Webb A, Schiff S. Volumetric brain analysis in neurosurgery: Part 1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT images. Journal Of Neurosurgery Pediatrics 2014, 15: 113-24. PMID: 25431902, DOI: 10.3171/2014.9.peds12426.Peer-Reviewed Original ResearchConceptsEdge trackerParticle filterGround vehicle navigationBrain image analysisCT imagesMRI data setsImage segmentationSegmentation algorithmAutonomous airVehicle navigationAccurate edgesNovel algorithmManual segmentationSegmentationMR imagesBrain dataVolumetric brain analysisData setsImage analysisSemiautomatic methodImagesModality independenceHistorical dataAlgorithmMRI dataVolumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus.
Mandell J, Kulkarni A, Warf B, Schiff S. Volumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus. Journal Of Neurosurgery Pediatrics 2014, 15: 125-32. PMID: 25431901, DOI: 10.3171/2014.9.peds12427.Peer-Reviewed Original ResearchConceptsFrontal-occipital horn ratioNeurocognitive outcomesBrain volumeCSF volumeFluid volumePediatric patientsBrain developmentEvaluation of hydrocephalusGoal of treatmentSmaller brain volumesLower cognitive outcomesPoor neurocognitive outcomesNormal brain developmentLarge fluid volumesHealthy brain developmentVolumetric brain analysisSurgical treatmentVentricular sizeHydrocephalic patientsCT scanHydrocephalusPatientsBayley ScalesBrain growthFine motorVolumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy.
Mandell J, Hill K, Nguyen D, Moser K, Harbaugh R, McInerney J, Nsubuga B, Mugamba J, Johnson D, Warf B, Boling W, Webb A, Schiff S. Volumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy. Journal Of Neurosurgery Pediatrics 2014, 15: 133-43. PMID: 25431899, DOI: 10.3171/2014.9.peds12428.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnterior Temporal LobectomyBrainCerebrospinal FluidChildChild, PreschoolCognitionCone-Beam Computed TomographyEpilepsy, Temporal LobeFemaleFrontal LobeHumansHydrocephalusInfantMagnetic Resonance ImagingMaleNeurosurgical ProceduresOccipital LobeOrgan SizePredictive Value of TestsSeizuresTreatment OutcomeUgandaConceptsTemporal lobe volumeMesial temporal sclerosisTemporal lobe epilepsyTemporal lobe resectionSeizure outcomeTemporal lobeVolumetric CT analysisBrain volumeLobe volumeSeizure controlStructural MRILobe resectionEngel class Ia outcomeClass Ia outcomeSelection of patientsCT volumetric analysisPreoperative CT scanSmaller brain volumesSmaller temporal lobeCURE Children's HospitalIncomplete seizure controlNormalized brain volumeWhole brain volumeCT analysisTemporal lobe structures
2012
Rainfall drives hydrocephalus in East Africa.
Schiff S, Ranjeva S, Sauer T, Warf B. Rainfall drives hydrocephalus in East Africa. Journal Of Neurosurgery Pediatrics 2012, 10: 161-7. PMID: 22768966, DOI: 10.3171/2012.5.peds11557.Peer-Reviewed Original Research
2011
Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants.
Warf B, Dagi A, Kaaya B, Schiff S. Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants. Journal Of Neurosurgery Pediatrics 2011, 8: 502-8. PMID: 22044377, DOI: 10.3171/2011.8.peds11221.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusFive-year survivalShunt placementPrimary brain injuryWorse functional outcomeKaplan-Meier methodLong-term outcomesLog-rank testOutcome of treatmentEndoscopic third ventriculostomyTreatment selection biasPublic health measuresOne-thirdUgandan infantsWorst sequelaeOperative mortalityNeonatal infectionFunctional outcomeThird ventriculostomyBrain injuryPrimary treatmentCommon causeInfant hydrocephalusSurvival advantageOriginal infection
2009
Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit
Schachter S, Guttag J, Schiff S, Schomer D, Contributors S. Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit. Epilepsy & Behavior 2009, 16: 3-46. PMID: 19780225, PMCID: PMC8118381, DOI: 10.1016/j.yebeh.2009.06.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrain MappingChildDrug ResistanceElectric Stimulation TherapyElectroencephalographyEngineeringEpilepsyHumansMagnetic Resonance ImagingMedical Laboratory ScienceMicroelectrodesNanoparticlesNeuronsNeurosurgeryNeurotoxinsPredictive Value of TestsSeizuresSpectroscopy, Near-InfraredTomography, Emission-Computed, Single-PhotonTomography, OpticalTranscranial Magnetic StimulationConceptsTreatment systemEvaluation of patientsTreatment of patientsGroup of cliniciansEpilepsy surgeryEngineering technologyFurther technological developmentEpilepsySeizure onset detectionPatientsEngineersSeizure predictionTechnologyApplicationsOnset detectionSurgeryCliniciansPhysiciansUnmetDiagnosis
2008
Fully optimized discrimination of physiological responses to auditory stimuli
Kruglikov S, Chari S, Rapp P, Weinstein S, Given B, Schiff S. Fully optimized discrimination of physiological responses to auditory stimuli. Journal Of Neural Engineering 2008, 5: 133. PMID: 18430975, PMCID: PMC2535922, DOI: 10.1088/1741-2560/5/2/004.Peer-Reviewed Original Research
2001
Early Seizure Detection
Jerger K, Netoff T, Francis J, Sauer T, Pecora L, Weinstein S, Schiff S. Early Seizure Detection. Journal Of Clinical Neurophysiology 2001, 18: 259-268. PMID: 11528297, DOI: 10.1097/00004691-200105000-00005.Peer-Reviewed Original Research
2000
Long-Term Follow-Up Data from the Shunt Design Trial
Kestle J, Drake J, Milner R, Sainte-Rose C, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Long-Term Follow-Up Data from the Shunt Design Trial. Pediatric Neurosurgery 2000, 33: 230-236. PMID: 11155058, DOI: 10.1159/000055960.Peer-Reviewed Original ResearchConceptsFirst shunt failureShunt failureDifferential pressure valvesOverall shunt survivalShunt Design TrialShunt failure ratesLate complicationsShunt surgeryShunt survivalInitial treatmentTerm followShunt obstructionDelta valvesHydrocephalic childrenOriginal trialPediatric hydrocephalusSurvival advantagePatient statusPatientsTrialsDesign trialSignificant differencesObstructionOverdrainageInfection
1998
Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus.
Drake J, Kestle J, Milner R, Cinalli G, Boop F, Piatt J, Haines S, Schiff S, Cochrane D, Steinbok P, MacNeil N. Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurgery 1998, 43: 294-303; discussion 303-5. PMID: 9696082, DOI: 10.1097/00006123-199808000-00068.Peer-Reviewed Original ResearchConceptsShunt obstructionDifferential pressure valvesShunt failurePediatric hydrocephalusCerebrospinal fluid shunt failuresCerebrospinal fluid shunt insertionTreatment failure rateShunt failure ratesOrbis-Sigma valvePediatric neurosurgical centersUpright positionCerebrospinal fluid shuntsIndependent case reviewShunt insertionCerebral ventricleDelta valvesHydrocephalic childrenFailure rateNeurosurgical centersOutcome eventsCase reviewPatientsObstructionShunt valveInfection
1997
Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study.
Hertz-Pannier L, Gaillard W, Mott S, Cuenod C, Bookheimer S, Weinstein S, Conry J, Papero P, Schiff S, Bihan D, Theodore W. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 1997, 48: 1003-12. PMID: 9109891, DOI: 10.1212/wnl.48.4.1003.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingElectrostimulation mappingLeft dominanceFunctional mapping techniquesMagnetic resonance imagingNoninvasive functional mappingRight-handed childrenLanguage dominanceBilateral languageHemodynamic changesEpilepsy surgeryPartial epilepsySurgery outcomesTemporal epilepsyAmobarbital testNeuronal activationWord generation taskFrontal lobeLanguage lateralizationRight dominanceNoninvasive assessmentResonance imagingFunctional MRISignal time courseBrain development
1995
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children
Heyes M, Saito K, Milstien S, Schiff S. Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children. Journal Of The Neurological Sciences 1995, 133: 112-118. PMID: 8583213, DOI: 10.1016/0022-510x(95)00164-w.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBacterial InfectionsBiomarkersBiopterinCentral Nervous System DiseasesCentral Nervous System NeoplasmsCerebral HemorrhageChildChild, PreschoolFemaleGuanosine TriphosphateHumansHydrocephalusInfantInfant, NewbornInterleukin-6KynurenineMaleNeopterinQuinolinic AcidTryptophan OxygenaseTumor Necrosis Factor-alphaConceptsCentral nervous systemQuinolinic acidImmune activationKynurenine pathwayNervous systemBacterial infectionsLevels of QUINCentral nervous system infectionCSF QUIN levelsNervous system infectionCytokine tumor necrosisCNS inflammationNeurological deficitsSystem infectionNeurologic dysfunctionCSF levelsQUIN levelsQUIN concentrationsInterleukin-6Tumor necrosisCerebrospinal fluidNeurotoxic metabolitesSensitive markerMacrophage activationPatientsFDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery,evaluation
Gaillard W, White S, MalOw B, Flamini R, Weinstein S, Sato S, Kufta C, Schiff S, Devinsky O, Fazilat S, Reeves P, Theodore W. FDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery,evaluation. Epilepsy Research 1995, 20: 77-84. PMID: 7713062, DOI: 10.1016/0920-1211(94)00065-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociPartial seizuresFDG-PETEpileptic focusGlucose metabolismRefractory complex partial epilepsyFocal MRI abnormalitiesInterictal glucose metabolismUnilateral EEG focusFDG-PET resultsFDG-PET hypometabolismComplex partial epilepsyFocal hypometabolismPET hypometabolismMRI abnormalitiesMetabolic abnormalitiesEpilepsy surgerySurgical interventionPartial epilepsyVideo-EEGEpileptogenic zonePoor responseRegional hypometabolismDrug treatment